Metal ion encapsulation: cobalt cages derived from polyamines, formaldehyde, and nitromethane

Comparison of 64Cu-Complexing Bifunctional Chelators for Radioimmunoconjugation: Labeling Efficiency, Specific Activity, and in Vitro/in Vivo Stability

“…We also included 2-benzyl-3-methylisothiocyanato-diethylenetriaminepentaaceticacid (2B3M-ITC-DTPA) and a sarcophagine ligand, (1-NH 2 -8-NHCO(CH 2 ) 3 CO 2 H)sar where sar = sarcophagine = 3,6,10,13,16,19-hexaazabicyclo[6.6.6]icosane (sar-CO 2 H) 45,46 . Encapsulating hexaamine sarcophagine ligands, first prepared by Sargeson and coworkers [47][48][49][50][51] , form extraordinary stable complexes with copper(II) and benefit from rapid complexation rates 52,53 . Methods have been developed to introduce reactive functional groups to the ligand framework [54][55][56] , to allow the ligands to be conjugated to peptides and antibodies with a goal of synthesizing copper radiopharmaceuticals that benefit from the special properties of sarcophagine ligands 21,45,46,[57][58][59][60][61] .…”

Preparation and immobilization of diNOsarcobalt(III) complex in zeolite y for the catalyzed production of hydrogen peroxide

“…Absorption bands measuring approximately 475 nm and 340 nm correspond to Co 3+ coordinated with six atoms of nitrogen, which belong to the three ethylenediamine ligands in the structure of the complex cation [Co(diNOsar)] 3+ . [9][10][11]19 The percentage of cobalt was determined to be 10% for both the free diNOsarcobalt(III) chloride and the fraction of immobilized complex. This is in good agreement with the cobalt percentage experimentally determined for diNOsarcobalt(III) chloride in previous works, which is 10.6%.…”

“…The water-soluble cobalt cage compound (1,8-dinitro-3,6,10,13,16,19-hexaazabicyclo-[6.6.6]eicosan) cobalt(III) chloride, abbreviated as diNOsarcobalt(III) chloride or [Co(diNOsar)]Cl 3 , (Figure 2) has excellent catalytic properties for this reaction, and its synthesis has been widely published in the literature. 10,11 However, the use of this catalyst in homogeneous medium requires additional complex separation procedures for isolation before a possible distillation for concentrating the hydrogen peroxide solutions. The present work investigates the synthesis of the complex cation, known as diNOsarcobalt(III) ([Co(diNOsar)] 3+ ), inside a water-insoluble porous solid that allows separation from the reaction medium (Figure 2).…”

“…, (diNOsar = 1,6,10,13,16,]eicosane), was synthesized and immobilized in the cavities of a Y zeolite by the reaction of precursor species in the pores of the zeolite. The encapsulated material was compared to the compound diNOsarcobalt(III) chloride, [Co(diNOsar)]Cl 3 .…”

Foreword to Professor Alan M. Sargeson Special Issue

“…[2] The reaction involves the seemingly incongruous self assembly of nine molecules to give a crystalline product in high yield. The synthesis followed on from the groundbreaking publication reporting the analogous chemistry with ammonia, instead of nitromethane, as the capping reagent to create the first cage ligand sepulchrate complexed to Co III and Co II .…”