Metal ion coordination in peptide fragments of neurotrophins: A crucial step for understanding the role and signaling of these proteins in the brain

Mendola, Diego La; Arena, Giuseppe; Pietropaolo, Adriana; Satriano, Cristina; Rizzarelli, Enrico

doi:10.1016/j.ccr.2021.213790

Cited by 13 publications

(14 citation statements)

References 204 publications

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“…Many studies have highlighted the distinctive biological role of copper ions in both neuronal and endothelial tissues that, despite their different biological structures, share similar signaling pathways [71][72][73]. In the neuronal system, copper ions seem to play a pivotal role in post-synaptic transmission, and its dyshomeostasis is involved in the etiology of numerous neurologic disorders, such as ALS, prion encephalopathies, PD and Alzheimer's disease [74][75][76][77]. Regarding its interaction with the endothelial system, copper has been recognized as an angiogenic factor.…”

Section: The Role Of Copper In Angiogenesismentioning

confidence: 99%

Angiogenin and Copper Crossing in Wound Healing

Cucci

Satriano

Marzo

et al. 2021

IJMS

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Angiogenesis plays a key role in the wound healing process, involving the migration, growth, and differentiation of endothelial cells. Angiogenesis is controlled by a strict balance of different factors, and among these, the angiogenin protein plays a relevant role. Angiogenin is a secreted protein member of the ribonuclease superfamily that is taken up by cells and translocated to the nucleus when the process of blood vessel formation has to be promoted. However, the chemical signaling that activates the protein, normally present in the plasma, and the transport pathways through which the protein enters the cell are still largely unclear. Copper is also an angiogenic factor that regulates angiogenin expression and participates in the activation of common signaling pathways. The interaction between angiogenin and copper could be a relevant mechanism in regulating the formation of new blood vessel pathways and paving the way to the development of new drugs for chronic non-healing wounds.

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Section: The Role Of Copper In Angiogenesismentioning

confidence: 99%

Angiogenin and Copper Crossing in Wound Healing

Cucci

Satriano

Marzo

et al. 2021

IJMS

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“…The atomic radius and electrostatic force drive them forming specific binding, which demonstrates that a highly sensitive sensor can be constructed by immobilizing or using label‐free ion probe [26] . Particularly, some of metal ions such as copper and zinc ions are necessary for the proper growth, functioning and maintenance of the cells and tissues, where the intracellular signals could be obtained by the bionic sensors [26b,27] . Thus, combined with precise metal ion sensing strategy and POCT, more quantitative and accurate metabolite composition in biological fluids can be obtained [28] .…”

Section: Resultsmentioning

confidence: 99%

Label‐Free Sensing of Cysteine through Cadmium Ion Coordination: Smartphone‐Based Electrochemical Detection

Liu

Jia

et al. 2022

ChemPlusChem

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The detection of biologically important compounds such as cysteine remains a challenge for monitoring body metabolism. This work proposes a transition metal ion coordination‐based label‐free cysteine sensor with smartphone‐based square wave voltammetry sensing system for the point‐of‐care testing (POCT). In the sensing system, potential excitation and current measurements were accomplished by a miniaturized and integrated circuit board with a smartphone to wirelessly control the system via Bluetooth. The electrochemical currents changed with the cysteine concentrations ranging from 0 μM to 200 μM with a linearity correlation coefficient of 0.9915. The limit of detection was as low as 0.0149 μM for cysteine. The smartphone‐based system provides an effective strategy for cysteine detection, and it can also serve as a promising portable sensing platform for the analysis of other small molecules.

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“…It is difficult to study the structures of peptides due to their inherent flexibility that often defies attempts at crystallization and challenges structure determination by solution-state NMR due to large conformational diversity. Despite the difficulties in using peptides in structural studies, they are commonly used as protein-mimetics for metal-binding of essential [34] and potentially toxic metals [35] and in drug design.…”

Section: Using Peptides As Biomimetics For Metal Bindingmentioning

confidence: 99%

Studying Peptide-Metal Ion Complex Structures by Solution-State NMR

Shalev

2022

IJMS

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Metal chelation can provide structural stability and form reactive centers in metalloproteins. Approximately one third of known protein structures are metalloproteins, and metal binding, or the lack thereof, is often implicated in disease, making it necessary to be able to study these systems in detail. Peptide-metal complexes are both present in nature and can provide a means to focus on the binding region of a protein and control experimental variables to a high degree. Structural studies of peptide complexes with metal ions by nuclear magnetic resonance (NMR) were surveyed for all the essential metal complexes and many non-essential metal complexes. The various methods used to study each metal ion are presented together with examples of recent research. Many of these metal systems have been individually reviewed and this current overview of NMR studies of metallopeptide complexes aims to provide a basis for inspiration from structural studies and methodology applied in the field.

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Metal ion coordination in peptide fragments of neurotrophins: A crucial step for understanding the role and signaling of these proteins in the brain

Cited by 13 publications

References 204 publications

Angiogenin and Copper Crossing in Wound Healing

Angiogenin and Copper Crossing in Wound Healing

Label‐Free Sensing of Cysteine through Cadmium Ion Coordination: Smartphone‐Based Electrochemical Detection

Studying Peptide-Metal Ion Complex Structures by Solution-State NMR

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