2013
DOI: 10.3389/fnagi.2013.00018
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Metal-induced neurodegeneration in C. elegans

Abstract: The model species, Caenorhabditis elegans, has been used as a tool to probe for mechanisms underlying numerous neurodegenerative diseases. This use has been exploited to study neurodegeneration induced by metals. The allure of the nematode comes from the ease of genetic manipulation, the ability to fluorescently label neuronal subtypes, and the relative simplicity of the nervous system. Notably, C. elegans have approximately 60–80% of human genes and contain genes involved in metal homeostasis and transport, a… Show more

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Cited by 64 publications
(60 citation statements)
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References 142 publications
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“…Although the toxic effects of CuO NPs on nematodes has not been extensively studied [15], copper ions from copper salts have been shown to be toxic to several species, including C . elegans [16], Panagrellus redivivus , and Pristionchus pacificus [17]. Exposure of laboratory-adapted C .…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Although the toxic effects of CuO NPs on nematodes has not been extensively studied [15], copper ions from copper salts have been shown to be toxic to several species, including C . elegans [16], Panagrellus redivivus , and Pristionchus pacificus [17]. Exposure of laboratory-adapted C .…”
Section: Introductionmentioning
confidence: 99%
“…elegans is an excellent model to study neuronal health as it offers a relatively simple nervous system [16]. This use has been exploited to study neurodegeneration induced by metals [16,20,33]. Neurodegeneration is a sensitive toxicological endpoint of copper ion exposure [34].…”
Section: Introductionmentioning
confidence: 99%
“…A single hermaphrodite has the ability to produce approximately 300 offspring, which enables high-throughput analyses 27 . C. elegans is less complex than the mammalian system, while still sharing high genetic homology (60–80%) 28 . The model organism C. elegans has been previously used in a limited number of studies to identify interactions between Cisplatin and signaling pathways in vivo 2931 .…”
Section: Introductionmentioning
confidence: 99%
“…(Zhao et al, 2014) Ferritin up-regulation occurred after SPION and Au-NP treatment, and similar effects were observed after C. elegans exposure to arsenic, cadmium and ethosuximide. (Chen et al, 2013, Chen et al, 2015, Petryszak et al, 2016 Hence, the effects of SPIONs in iron homeostasis might be part of a more general response to toxicants and not necessarily linked to oxidative dissolution of the SPION core into free iron.…”
Section: Evaluation Of Specific Molecular Markersmentioning
confidence: 99%