Metal-Free Thiocarbamation of Quinolinones: Direct Access to 3,4-Difunctionalized Quinolines and Quinolinonyl Thiocarbamates at Room Temperature

Ying, Linkun; Chen, Yao; Song, Xiangrui; Song, Zengqiang

doi:10.1021/acs.joc.3c01504

Cited by 1 publication

(1 citation statement)

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“…Very recently, Song and coworkers disclosed a metal-free thiocarbamation of quinolinones 172 for the access of a diversity of difunctionalized quinolines 175, bearing a thiocarbamate group at the C3-position and an acyloxyl group at the C4-position, and quinolinonyl thiocarbamates 176 using tetraalkylthiuram disulfides 82 and hypervalent iodine(III) reagents (HIRs, 173-174) at room temperature (Scheme 45). [141] It was found that difunctionalized quinolines 175 are possibly formed from quinolinonyl thiocarbamates 176 by nucleophilic attack of carboxylic anions derived from HIRs. Due to the weak nucleophilicity of trifluoroacetate anion, the reaction with phenyliodonium bis(trifluoroacetate) (174, PIFA) only provided the corresponding quinolinonyl thiocarbamates 176.…”

Section: Cà H Thiocarbamationmentioning

confidence: 99%

Direct C−H Sulfuration: Synthesis of Disulfides, Dithiocarbamates, Xanthates, Thiocarbamates and Thiocarbonates

Sun,

Xu,

Yang

et al. 2024

Chemistry An Asian Journal

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In light of the important biological activities and widespread applications of organic disulfides, dithiocarbamates, xanthates, thiocarbamates and thiocarbonates, the continual persuit of efficient methods for their synthesis remains crucial. Traditionally, the preparation of such compounds heavily relied on intricate multi‐step syntheses and the use of highly prefunctionalized starting materials. Over the past two decades, the direct sulfuration of C–H bonds has evolved into a straightforward, atom‐ and step‐economical method for the preparation of organosulfur compounds. This review aims to provide an up‐to‐date discussion on direct C–H disulfuration, dithiocarbamation, xanthylation, thiocarbamation and thiocarbonation, with a special focus on describing scopes and mechanistic aspects. Moreover, the synthetic limitations and applications of some of these methodologies, along with the key unsolved challenges to be addressed in the future are also discussed. The majority of examples covered in this review are accomplished via metal‐free, photochemical or electrochemical approaches, which are in alignment with the overraching objectives of green and sustainable chemistry. This comprehensive review aims to consolidate recent advancements, providing valuable insights into the dynamic landscape of efficient and sustainable synthetic strategies for these crucial classes of organosulfur compounds.

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Section: Cà H Thiocarbamationmentioning

confidence: 99%