Metal-free synthesis of dihydrofuran derivatives as anti-vicinal amino alcohol isosteres

Abstract

Dihydrofuran cores are commonly incorporated into synthetically and pharmacologically significant scaffolds in natural product and drug discovery chemistry.

Metal-free synthesis of carbamoylated dihydroquinolinones via cascade radical annulation of cinnamamides with oxamic acids

“…In recent years, much effort has been made in modifying organic synthetic methods to make them sustainable for the betterment of our environment. Transition-metal-free reactions 1 are becoming increasingly important in modern organic synthesis, as they are not only cost-effective but also environmentally friendly. Transition metal catalysts have many limitations and drawbacks from the perspective of green and sustainable chemistry.…”