Metal-free photocatalyzed homo- and cross-dimerizations of α-hydroxyl ketones via dual C(sp³)–H functionalization: synthesis of 2,3-dihydroxyl-1,4-butanediones

Abstract

The dimerization reactions of α-hydroxy ketones in the α-carbon site have been realized by visible light photocatalysis in the fashion of both homo- and cross coupling, leading to the synthesis...

Visible-light-induced Ritter-type amidation of α-hydroxy ketones in the selective synthesis of α,α-diamido and monoamido ketones

“…10 Benefiting from the dramatic advances of visible light induced transformation, 11 our group has recently reported the first metal-free photocatalytic homo- and cross-dimerization of α-hydroxy ketones via a radical process. 12 While Ritter reactions involving carbocation generation via alcohol dehydroxylation or benzyl C–H functionalization have been reported, using α-hydroxy ketones as precursors for Ritter-type amidation remains unknown. On the other hand, catalytic transformation of ubiquitous C–H and C–OH bonds into C–N bonds represents a valuable strategy for fabricating nitrogen-containing compounds.…”