Metal‐Free K2S2O8 Mediated Synthesis of 3‐(Substituted)‐2‐Arylisoindolin‐1‐One Derivatives With Cascade C−N/C−C Bond Formations Via Radical Cyclization
Soumitra Rana,
Rajiv Karmakar,
Uday Shee
et al.
Abstract:A facile technique was demonstrated for the synthesis of 2‐hydroxy‐2‐[N‐(alkyl/aryl/heteroaryl)‐3‐oxoisoindolin‐1‐yl]‐1H‐indene‐1,3(2H)‐diones by using a metal‐ free persulfate‐mediated one pot three‐component reaction. The reaction involved the combination effect of TBAB (PTC) and K2S2O8 with the addition of the amine to phthalaldehyde and 2,2‐dihydroxyindane‐1,3‐dione to generate isoindolin‐1‐one in‐situ, followed by cyclization.This lactamization process facilitated the formation of C–N bonds under controll… Show more
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