Metal‐Free Iodine‐Promoted Oxidative Dehydrogenative Aromatization of Pyrazolidin‐3‐ones and Pyrazolines: An Efficient and Practical Approach to Functionalized Arylpyrazoles

Abstract

An efficient and practical iodine‐promoted oxidative aromatization of pyrazolidin‐3‐ones and pyrazolines has been developed under metal‐free, additive‐free and external‐oxidant‐free conditions in good yields with a broad functional group tolerance. In this transformation, a series of functionalized arylpyrazole derivatives could be obtained successfully. More importantly, the current methodology can be utilized as a convenient handle to elaborate pharmaceutical candidates.