Metal‐Free Intramolecular Hydroalkoxylation of Alkyne: Recent Advances

Abstract

Dedicated to Professor Sundarbabu BaskaranHydroalkoxylation of alkyne offers a unique platform to rapidly access structurally complex and densely functionalized oxygenbearing heterocycles. Further, to enhance the synthetic utility, various cascade reactions including hydroalkoxylation have been reported in both stereo-as well as enantioselective manner under metal and metal-free conditions. A collection of the most representative and recent methods employing metalfree hydroalkoxylation events are presented in this review article. Organocatalytic Intramolecular Hydroalkoxylation CascadeUndoubtedly, organocatalytic Michael addition reaction has come fore as one of the powerful methods for the formation of CÀ C, CÀ N, and CÀ O bonds. [12] In this context, nitroenynes have

Transition metal catalysed cascade C–C and C–O bond forming events of alkynes

“…Previously, we have described various literature assessments on the transition metal and metal-free functionalization of alkynes involving C-C and C-N bond-forming reactions. [19][20][21] In this review, we aim to present different conceptual approaches on the transition metal-catalysed functionalization of alkynes involving C-and C-O bond formation. Further, we present detailed insights into the mechanism of different transformations.…”

Hydroalkoxylation-Initiated Cascade on Sulfone-Tethered Aryl Alkynols Gives Cyclic and Spiro-Heterocyclic β-Ketosulfones

“…in combination with hydroalkoxylation of alkyne have been described . While transition-metal-catalyzed hydroalkoxylation cascades of alkynes have been encountered frequently, corresponding metal-free approaches are scarce in the literature . This is somewhat intriguing given the cost and environmental considerations, as the latter are likely to fall under the regime of sustainable chemistry more often than the former.…”