Metal-free hydroxylation of tertiary ketones under intensified and scalable continuous flow conditions

Kassin, Victor-Emmanuel; Toupy, Thomas; Petit, Guillaume; Bianchi, Pauline; Salvadeo, Elena; Monbaliu, Jean‐Christophe M.

doi:10.1007/s41981-019-00073-6

Cited by 7 publications

(3 citation statements)

References 48 publications

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“…The intrinsic features of this technology make it possible to solve many problems encountered in chemical synthesis. Fast mixing and efficient heat transfers are now well-established assets of flow reactors and often deployed for reactions sensitive to local stoichiometry, 10 biphasic systems, 11,12 strongly exothermic and high-temperature processes with sensitive materials. 13 Flow chemistry also brings novel challenges to the Chemist and Chemical Engineer, such as for handling solids and high viscosity materials.…”

Section: Chemical Synthesis: Thinking Small To Produce More… and Bettermentioning

confidence: 99%

Will the next generation of chemical plants be in miniaturized flow reactors?

Monbaliu

Legros

2023

Lab Chip

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Section: Chemical Synthesis: Thinking Small To Produce More… and Bettermentioning

confidence: 99%

Will the next generation of chemical plants be in miniaturized flow reactors?

Monbaliu

Legros

2023

Lab Chip

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“…Later, the hydroxylation process was extended to a library of ketones for the preparation of α-ketols of industrial interest. [126]…”

Section: Reduction Reactionsmentioning

confidence: 99%

Continuous Flow Organophosphorus Chemistry

2020

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Organophosphorus derivatives are widespread compounds that chemists find from the bench to the plant, with numerous daily life applications. Besides their common utility for a wide range of notorious reactions such as the Wittig and Horner‐Wadsworth‐Emmons olefinations, the Arbuzov reaction, the Staudinger reaction, the Mitsunobu reaction as well as ligands for a large variety of organometallic complexes, organophosphorus compounds have also found numerous applications as active pharmaceutical ingredients and agrochemicals. Some organophosphorus derivatives are also infamously known as Chemical Warfare Agents. Within the context of generalized adoption of new process technologies in the Chemistry Toolbox, this review intends to give an update on the most recent and significant advances in continuous flow organophosphorus chemistry. Selected examples in methodology, total synthesis and for the preparation of industrially relevant targets are discussed for illustrating the assets of flow chemistry.

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“…Such a scheme alleviates the safety concerns of handling and stockpiling reactive chemicals. Building upon our expertise in developing continuous flow processes [73][74][75][76][77] and the handling of nitroso species, 37,38,78,79 a solution was sought for exploiting, under safe conditions, the unique reactivity of α-chloronitroso derivatives at its fullest.…”

Section: Introductionmentioning

confidence: 99%