Metal-free [3+3] heteroannulation of thioamides with alkynyl NHPI-esters to access 2H-1,3-thiazin-4(3H)-ones

A DFT study of NHC-catalyzed reactions of [3+3] annulations of 2-bromoenals and thioamides: mechanisms and regio- and stereoselectivities

“…[1][2][3] 1,3-Thiazin-4-ones also have applications in organic syntheses and transformations. [4][5][6] Many methods have been developed to synthesize 1,3-thiazin-4-ones, [7][8][9][10] but the drawbacks, such as multiple steps and poor atom economy, have encouraged chemists to find simple, efficient and environmentally friendly synthetic routes.…”