Metal-free, 2-MeTHF mediated C(sp)–H functionalization of alkynes with anilines to access diaryl 1,2-diketones bearing lower<i>E</i>-factors

Bhukta, Swadhapriya; Chatterjee, Rana; Dandela, Rambabu

doi:10.1039/d3gc00267e

Cited by 11 publications

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“…13 In our recent study, we have demonstrated the versatility of vinyl azides towards the synthesis of α-ketoamides. 14 In the exploration of several practical and efficient methodologies, 15 herein we have developed a simple and novel approach for synthesizing 2,4,6-trisusbtituted pyridines from vinyl azides and benzyl amines. The copper( ii ) and iodine-mediated system enables oxidative deamination and cyclization, providing 2,4,6-triaryl pyridines via a cascade reaction.…”

Section: Introductionmentioning

confidence: 99%

Copper catalysed oxidative cascade deamination/cyclization of vinyl azide and benzylamine for the synthesis of 2,4,6-triarylpyridines

Chatterjee

Bhukta

Angajala³

et al. 2023

Org. Biomol. Chem.

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Section: Introductionmentioning

confidence: 99%

Copper catalysed oxidative cascade deamination/cyclization of vinyl azide and benzylamine for the synthesis of 2,4,6-triarylpyridines

Chatterjee

Bhukta

Angajala³

et al. 2023

Org. Biomol. Chem.

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Efficient Cross‐Dehydrogenative Coupling (CDC) Enabled by Cu‐PMo₁₂ towards the Synthesis of Pyrimidinyl Carbamates at Room Temperature

et al. 2023

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A novel and efficient approach has been developed for the direct synthesis of pyrimidinyl dimethylcarbamate using Cu-PMo 12 complex. Basically, Cu-PMA catalyst successfully enabled the cross-dehydrogenative coupling (CDC) reaction between N-benzoyl cytosine and formamides in the presence of tert-butyl hydroperoxide and triethyl amine. Herein, Cu(I/II) catalytic system facilitated the oxidative coupling of the carbamide function, generating a new CÀ O bond and has been identified as more efficient compared to other commercially available Cu (I) or Cu (II) salts. Furthermore, the characterization of the catalyst was performed by XPS, SEM and EDX analysis. The present method also demonstrates a simple procedure with least catalyst loading, a wide variety of substrates with excellent functional group compatibility, high yields, ambient conditions, and operational simplicity.

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Silver molybdate (Ag‐PMo₁₂) nanocomposite: An efficient catalyst for the one‐pot synthesis of 3,3‐diindolyl derivatives in aqueous medium

Gaware,

Kamble,

Chatterjee

et al. 2023

ChemistrySelect

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An efficient methodology has been developed for the synthesis of 3,3‐di(indolyl)oxindoles and bis(indolyl)methanes under mild conditions. The efficient condensation reaction of indoles with isatin and aldehyde led to the corresponding derivatives in the presence of silver molybdate (Ag‐PMo12) nanocomposite and aqueous medium. In addition, the silver‐doped catalytic system enables the one‐pot formation of diindolyl derivatives with excellent yields, short reaction times and under environmental benign conditions.

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Metal-free, 2-MeTHF mediated C(sp)–H functionalization of alkynes with anilines to access diaryl 1,2-diketones bearing lowerE-factors

Abstract: A metal-free and efficient oxidative C(sp)–H functionalization of alkynes has been developed for the synthesis of 1,2-diketones. A composite of tert-Butyl nitrite and ascorbic acid effectively promoted the oxidative addition...

Cited by 11 publications

References 65 publications

Copper catalysed oxidative cascade deamination/cyclization of vinyl azide and benzylamine for the synthesis of 2,4,6-triarylpyridines

Copper catalysed oxidative cascade deamination/cyclization of vinyl azide and benzylamine for the synthesis of 2,4,6-triarylpyridines

Efficient Cross‐Dehydrogenative Coupling (CDC) Enabled by Cu‐PMo₁₂ towards the Synthesis of Pyrimidinyl Carbamates at Room Temperature

Silver molybdate (Ag‐PMo₁₂) nanocomposite: An efficient catalyst for the one‐pot synthesis of 3,3‐diindolyl derivatives in aqueous medium

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Metal-free, 2-MeTHF mediated C(sp)–H functionalization of alkynes with anilines to access diaryl 1,2-diketones bearing lowerE-factors

Abstract: A metal-free and efficient oxidative C(sp)–H functionalization of alkynes has been developed for the synthesis of 1,2-diketones. A composite of tert-Butyl nitrite and ascorbic acid effectively promoted the oxidative addition...

Cited by 11 publications

References 65 publications

Copper catalysed oxidative cascade deamination/cyclization of vinyl azide and benzylamine for the synthesis of 2,4,6-triarylpyridines

Copper catalysed oxidative cascade deamination/cyclization of vinyl azide and benzylamine for the synthesis of 2,4,6-triarylpyridines

Efficient Cross‐Dehydrogenative Coupling (CDC) Enabled by Cu‐PMo12 towards the Synthesis of Pyrimidinyl Carbamates at Room Temperature

Silver molybdate (Ag‐PMo12) nanocomposite: An efficient catalyst for the one‐pot synthesis of 3,3‐diindolyl derivatives in aqueous medium

Contact Info

Product

Resources

About

Efficient Cross‐Dehydrogenative Coupling (CDC) Enabled by Cu‐PMo₁₂ towards the Synthesis of Pyrimidinyl Carbamates at Room Temperature

Silver molybdate (Ag‐PMo₁₂) nanocomposite: An efficient catalyst for the one‐pot synthesis of 3,3‐diindolyl derivatives in aqueous medium