Metal fractionation in soils and assessment of environmental contamination in Vallecamonica, Italy

Borgese, Laura; Federici, Stefania; Zacco, Annalisa; Gianoncelli, Alessandra; Rizzo, Luigi; Smith, Donald R.; Donna, Filippo; Lucchini, Roberto; Depero, Laura E.; Bontempi, Elza

doi:10.1007/s11356-013-1473-8

Cited by 78 publications

(44 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Mn exposure of these children has been carefully monitored by measurements of Mn concentrations in samples from the their home environment and shown increased Mn concentrations in samples from the Valcamonica and Bagnolo Mella compared to Lake Garda (Borgese et al, 2011, 2013; Lucas et al, 2015). The children have also undergone comprehensive neurological and neuropsychological testing at adolescent age, including tests for IQ, motor function and behaviour; however, neurological outcomes were not in included in the present study.…”

Section: Methodsmentioning

confidence: 99%

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

et al. 2018

View full text Add to dashboard Cite

Background: Manganese (Mn) is an essential metal that can become neurotoxic at elevated levels with negative consequences on neurodevelopment. We have evaluated the influence of single nucleotide polymorphisms (SNPs) in Mn transporter genes SLC30A10 and SLC39A8 on Mn concentrations in dentine, a validated biomarker that reflects Mn tissue concentrations early in life. Methods: The study included 195 children with variable environmental Mn exposure. Mn concentrations in dentine representing fetal, early postnatal and early childhood developmental periods were measured using laser ablation-inductively coupled plasma mass spectrometry. SLC30A10 rs12064812 (T/C) and SLC39A8 rs13107325 (C/T) were genotyped by TaqMan real time PCR and SLC30A10 rs1776029 (G/A) by pyrosequencing; and SNPs were analyzed in association with Mn in dentine. Results: SLC39A8 rs13107325 rare allele (T) carriers had significantly higher Mn concentrations in postnatal dentine (110%, p = 0.008). For all SNPs we also observed non-significant associations with Mn concentrations in dentine in opposite directions for fetal and early postnatal periods. Furthermore, there were significant differences in the influence of SLC30A10 rs1776929 genotypes on Mn concentrations in dentine between sexes. Discussion: The findings from this study indicate that common SNPs in Mn transporters influence Mn homeostasis in early development and may therefore be important to consider in future studies of early life Mn exposure and health effects. Our results also suggest that the influence of these transporters on Mn regulation may differ by developmental stage, as well as between girls and boys.

show abstract

Section: Methodsmentioning

confidence: 99%

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Minor modification was made to the existing protocol and 7 M HNO 3 was used instead of aqua-regia for extraction of trace metals in the residual fraction and for pseudo-total extraction (Borgese et al 2013; SIS 2003). Certified reference sediments (CRM-601) and duplicate samples were used to test the accuracy and efficiency of the extraction procedure, and reproducibility of our results.…”

Section: Methodsmentioning

confidence: 99%

Temporal and spatial distribution of trace metals in the Rufiji delta mangrove, Tanzania

Minu

Routh

Dario

et al. 2018

Environ Monit Assess

View full text Add to dashboard Cite

Spatial and temporal distribution of trace metals and their cycling is a key issue for understanding the ongoing biogeochemical processes in coastal environments. Sediment cores were collected from six different sampling locations from the Rufiji delta mangrove forests in southeastern coastal Tanzania that are perceived to be impacted by urban development and agricultural activities in the catchment, and pollution in upstream sections of the Rufiji River. The chronology and sediment accumulation rates at these sampling sites were derived based on the distribution of 210Pbexcess method. The trace metals (As, Cd, Cr, Cu, Ni, Pb, and Zn) were sequentially extracted as per the BCR method and analyzed. The results indicate that the mass accumulation rates range from 0.40 g cm−2 year−1 (cores NR3 and NR4) to 1.75 g cm−2 year−1 (core SR1). Trace metals in the cores are mainly associated with the residual phase and their abundances in sediments are ranked as Cr > Zn > Ni > Cu > Pb > Cd. The results imply that trace metals in the Rufiji delta mangroves are mainly of crustal origin, and they are less sensitive to weathering. Further, these metals are least available for uptake by plants and they pose limited threat to the biota.

show abstract

“…More detailed information on the study areas were published previously (Lucchini et al, 2007, 2012). Environmental levels of Mn and other metals have been thoroughly characterized in the study regions, showing that levels of Mn are significantly higher in Valcamonica compared to the Garda Lake reference area for airborne particles (Borgese et al 2011, 2012), deposited outdoor dust (Zacco et al 2009), indoor house and attic dust (Pavilonis, submitted), soil (Borgese et al, 2013), and locally cultivated leafy vegetables (Ferri et al 2012). …”

Section: Methodsmentioning

confidence: 99%

Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese

et al. 2014

View full text Add to dashboard Cite

Background Manganese (Mn) is an essential element that can become neurotoxic through various exposure windows over the lifespan. While there is clear evidence of Mn neurotoxicity in pediatric and adult occupational populations, little is known about effects in the elderly who may exhibit enhanced susceptibilities due to compromised physiology compared to younger adults. In the province of Brescia, Italy, the Valcamonica area has been the site of three ferroalloy plants operating from 1902 to 2001. Metal emissions of Mn and to a lesser extent lead (Pb) have impacted the surrounding environment, where a high prevalence of Parkinsonism was previously observed. This study aimed to assess neurocognitive and motor functions in healthy elderly subjects residing for most of their lifetime in Valcamonica or in a reference area unimpacted by ferroalloy plant activity. Methods Subjects were enrolled for extensive neurobehavioral assessment of motor, cognitive and sensory functions. Exposure was assessed with 24hour personal air sampling for PM10 airborne particles, surface soil and tap water measurement at individual households, Mn levels in blood and urine and Pb in blood. Dose-response relationships between exposure indicators and biomarkers and health outcomes were analyzed with Generalized (linear and logistic) Additive Models (GAM). Results A total of 255 subjects (55% women) were examined; most (52.9%) were within the 65–70 years age class. Average airborne Mn was 26.41 ng/m3 (median 18.42) in Valcamonica and 20.96 ng/m3 (median 17.62) in the reference area. Average Mn in surface soil was 1026 ppm (median 923) in Valcamonica and 421 ppm (median 410) in the reference area. Manganese in drinking water was below the LDL of 1 µg/L. The GAM analysis showed significant association between airborne Mn (p=0.0237) and the motor coordination tests of the Luria Nebraska Neuropsychological Battery. The calculation of the Benchmark Dose using this dose response relationship yielded a lower level confidence interval of 22.7 ng/m3 (median 26.4). For the odor identification score of the Sniffin Stick test, an association was observed with soil Mn (p=0.0006) and with a significant interaction with blood Pb (p=0.0856). Significant dose-responses resulted also for the Raven’s Colored Progressive Matrices with the distance from exposure point source (p=0.0025) and Mn in soil (p=0.09), and for the Trail Making test, with urinary Mn (p=0.0074). Serum prolactin (PRL) levels were associated with air (p=0.061) and urinary (p=0.003) Mn, and with blood Pb (p=0.0303). In most of these associations age played a significant role as an effect modifier. Conclusion Lifelong exposure to Mn was significantly associated with changes in odor discrimination, motor coordination, cognitive abilities and serum PRL levels. These effects are consistent with the hypothesis of a specific mechanism of toxicity of Mn on the dopaminergic system. Lead co-exposure, even at very low levels, can further enhance Mn toxicity.

show abstract

Metal fractionation in soils and assessment of environmental contamination in Vallecamonica, Italy

Cited by 78 publications

References 30 publications

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

Polymorphisms in manganese transporters show developmental stage and sex specific associations with manganese concentrations in primary teeth

Temporal and spatial distribution of trace metals in the Rufiji delta mangrove, Tanzania

Neurofunctional dopaminergic impairment in elderly after lifetime exposure to manganese

Contact Info

Product

Resources

About