Metal exposure and Alzheimer’s pathogenesis

Liu, Guijian; Huang, Weidong; Moir, Robert D.; Vanderburg, Charles R.; Lai, Barry; Peng, Zicheng; Tanzi, Rudolph E.; Rogers, Jack T.; Huang, Xudong

doi:10.1016/j.jsb.2005.12.011

Cited by 120 publications

(100 citation statements)

References 66 publications

(66 reference statements)

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“…Metal dyshomeostasis, especially for endogenous metal ions such as copper (Cu), iron (Fe), manganese (Mn), zinc (Zn) or the exogenous contaminant aluminum (Al), has attracted recent interest on the etiology of a variety of neurodegenerative conditions [1]. Maintaining transition metal homeostasis is known to be important in a wide variety of biological functions, such as anti-oxidant defense mechanisms.…”

Section: Introductionmentioning

confidence: 99%

Silicic Acid and Beer Consumption Reverses the Metal Imbalance and the Prooxidant Status Induced by Aluminum Nitrate in Mouse Brain

González‐Muñoz

Garcimartán

Meseguer

et al. 2017

JAD

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Section: Introductionmentioning

confidence: 99%

Silicic Acid and Beer Consumption Reverses the Metal Imbalance and the Prooxidant Status Induced by Aluminum Nitrate in Mouse Brain

González‐Muñoz

Garcimartán

Meseguer

et al. 2017

JAD

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“…18) Imbalances in the levels and distribution of these metals in the brain, especially zinc, copper and iron may play a role in dementias like Alzheimer's disease (the so-called "metal hypothesis"). 19) ) in AD patients is 3-7 times higher than the level in healthy individuals. 20) In our previous studies, we determined the significant effects of the synthesized compounds, which have different halogen atoms (F, Cl, Br, I) on meta-and para-positions of aniline rings, on acetyl-and butyryl-cholinesterase inhibition.…”

mentioning

confidence: 71%

Microwave-Assisted Synthesis, Molecular Docking, and Cholinesterase Inhibitory Activities of New Ethanediamide and 2-Butenediamide Analogues

Koca

Yerdelen

Anil

et al. 2015

CHEMICAL & PHARMACEUTICAL BULLETIN

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A novel series of meta-substituted ethanediamide and 2-butenediamide derivatives were synthesized and tested for their ability to inhibit electric eel acetylcholinesterase (AChE) and equine serum butyrylcholinesterase (BuChE). The synthesized compounds were evaluated against ChE enzymes using the colorimetric method described by Ellman et al. (Biochem. Pharmacol., 7, 1961). It was revealed that some synthesized compounds exhibited high anticholinesterase activity, among which compounds 1f and 2f were the most active inhibitors against BuChE (IC 50 value 1.47 µM) and AChE (IC 50 value 2.09 µM), respectively. Docking simulations revealed that the inhibitors 1f and 2f are capable of simultaneously binding the peripheral anionic site as well as the catalytic anionic site of both ChE enzymes. These derivatives are considered interesting candidates for Alzheimer's disease treatment.

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“…[8,15,19,28,[30][31][32][33][34] Microprobe SRXRF analysis has also been performed on whole cells grown on silicon nitride membranes following fixation using glutaraldehyde or methanol. [35][36] For elements/drugs that possess reasonably strong interactions with intracellular biomolecules, thin-section analysis is beneficial as it facilitates high resolution imaging which is required for differentiation of organelles and provides confirmation of cell membrane penetration of the drug. The protocol for preparation of thin sections includes chemical fixation (e.g., the use of glutaraldehyde in preference to formalin), dehydration, and resin infiltration.…”

Section: Microprobe X-ray Fluorescence Imagingmentioning

confidence: 99%

Synchrotron Radiation Spectroscopic Techniques as Tools for the Medicinal Chemist: Microprobe X-Ray Fluorescence Imaging, X-Ray Absorption Spectroscopy, and Infrared Microspectroscopy

Dillon

2012

Aust. J. Chem.

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. (2012). Synchrotron radiation spectroscopic techniques as tools for the medicinal chemist: microprobe X-Ray fluorescence imaging, X-Ray absorption spectroscopy, and infrared microspectroscopy. Australian Journal of Chemistry: an international journal for chemical science, 65 (3), 204-217. Synchrotron radiation spectroscopic techniques as tools for the medicinal chemist: microprobe X-Ray fluorescence imaging, X-Ray absorption spectroscopy, and infrared microspectroscopy AbstractThis review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescence spectroscopy/imaging, X-ray absorption spectroscopy, and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist. A brief description of the principles of the techniques is given with emphasis on the advantages of using synchrotron radiation-based instrumentation rather than instruments using typical laboratory radiation sources. This review focuses on several recent applications of these techniques to solve inorganic medicinal chemistry problems, focusing on studies of cellular uptake, distribution, and biotransformation of established and potential therapeutic agents. The importance of using these synchrotron-based techniques to assist the development of, or validate the chemistry behind, drug design is discussed. AbstractThis review updates the recent advances and applications of three prominent synchrotron radiation techniques, microprobe X-ray fluorescent spectroscopy/imaging, X-ray absorption spectroscopy and infrared microspectroscopy, and highlights how these tools are useful to the medicinal chemist. A brief description of the principles of the techniques is given with emphasis on the advantages of using synchrotron radiation-based instrumentation rather than instruments using typical laboratory radiation sources. This review focuses on a number of recent applications of these techniques to solve inorganic medicinal chemistry problems, focusing on studies of cellular uptake, distribution and biotransformation of established and potential therapeutic agents. The importance of using these synchrotron-based techniques to assist the development, or validate the chemistry behind, drug design is discussed.3

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Metal exposure and Alzheimer’s pathogenesis

Cited by 120 publications

References 66 publications

Silicic Acid and Beer Consumption Reverses the Metal Imbalance and the Prooxidant Status Induced by Aluminum Nitrate in Mouse Brain

Silicic Acid and Beer Consumption Reverses the Metal Imbalance and the Prooxidant Status Induced by Aluminum Nitrate in Mouse Brain

Microwave-Assisted Synthesis, Molecular Docking, and Cholinesterase Inhibitory Activities of New Ethanediamide and 2-Butenediamide Analogues

Synchrotron Radiation Spectroscopic Techniques as Tools for the Medicinal Chemist: Microprobe X-Ray Fluorescence Imaging, X-Ray Absorption Spectroscopy, and Infrared Microspectroscopy

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