Metal-enhanced fluorescent dye-doped silica nanoparticles and magnetic separation: A sensitive platform for one-step fluorescence detection of prostate specific antigen

Xu, Dangdang; Deng, Yun-Liang; Li, Chengyu; Lin, Yi; Tang, Hong‐Wu

doi:10.1016/j.bios.2016.09.034

Cited by 87 publications

(27 citation statements)

References 45 publications

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“…The next trend arises from analyte nature, and demonstrates that the increase in complexity of analytes requires more complicated substrates and procedures. This can be traced from the simple metal films and nanoparticles used for small organic molecules and proteins [ 18 , 22 , 34 , 39 , 58 , 60 ] to the complicated plasmonic chips, platforms, nanostructures, and quantum dots used for DNA sensing and detection of antibodies, toxins, and bacteria [ 77 , 82 , 94 , 97 , 99 , 101 ]. Furthermore, the last trend, arising from the differences between substrates and their increasing level of sophistication, states the following: the increase in the complexity of the substrate leads to better sensitivity and consequently, a lower limit of detection.…”

Section: Discussion Of Trendsmentioning

confidence: 99%

“…Similarly, the group of Dr. Tang modified silver nanoparticles with a layer of silica oxide and fluorescent dye and assessed this nanoparticle by detection of PSA [ 82 ]. The results of this experiment can be observed in Fig.…”

Section: Proteinsmentioning

confidence: 99%

“…(C) Calibration curve for PSA detection. Excitation: 450 nm; Reprinted by the permission of Elsevier, Xu et al [ 82 ]. …”

Section: Proteinsmentioning

confidence: 99%

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Review: Applications of surface-enhanced fluorescence (SEF) spectroscopy in bio-detection and biosensing

Sultangaziyev

Bukasov

2020

Sensing and Bio-Sensing Research

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Surface-enhanced fluorescence (SEF) is rapidly becoming one of the main spectroscopic techniques for the detection of a variety of biomolecules and biomarkers. The main reasons for this trend are the high sensitivity and selectivity, robustness, and speed of this analytical method. Each year, the number of applications that utilize this phenomenon increases and with each such work, the complexity and novelty of the used substrates, procedures, and analytes rises. To obtain a clearer view of this phenomenon and research area, we decided to combine 76 valuable research articles from a variety of different research groups into this mini-review. We present and describe these works concisely and clearly, with a particular interest in the quantitative parameters of the experiment. These sources are classified according to the nature of the analyte, on the contrary to most reviews, which sort them by substrate nature. This point of view gives us insight into the development of this research area and the consequent increase in the complexity of the analyte nature. Moreover, this type of sorting can show possible future routes for the expansion of this research area. Along with the analytes, we can also pay attention to the substrates used for each situation and how the development of substrates affects the direction of research and subsequently, the choice of an analyte. About 108 sources and several interesting trends in the SEF research area over the past 25 years are discussed in this mini-review.

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Section: Discussion Of Trendsmentioning

confidence: 99%

Section: Proteinsmentioning

confidence: 99%

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Review: Applications of surface-enhanced fluorescence (SEF) spectroscopy in bio-detection and biosensing

Sultangaziyev

Bukasov

2020

Sensing and Bio-Sensing Research

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“…The magnetic nature of the nanocomposite allowed for an easy separation upon recognition of PSA to avoid any undesired background signal. Silver nanoparticles have also been encapsulated within silica layers to produce a biosensing nanocomposite (Ag@SiO 2 @SiO 2 -[Ru(bpy) 3 ] 2+ towards PSA [71]. In this case, an organic fluorophore has been employed, taking advantage of the luminescent enhancement provided by the interaction of the [Ru(bpy) 3 ] 2+ and the silver cores, the PSA selectivity was achieved thanks to a PSA antibody and magnetic separation was possible after analysis.…”

Section: Psa Detection By Optical Methodsmentioning

confidence: 99%

Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

Perry

Cortezon‐Tamarit

Pascu

2019

Front. Chem. Sci. Eng.

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Prostate cancer has a high incidence in men and remains the second cause of mortality due to cancer worldwide. As the development of the disease is greatly correlated to age, the identification of novel detection methods reliable, efficient, and cost effective is a matter of significant importance in the ageing population of western societies. The detection of the prostate specific antigen (PSA) in blood samples has been the preferred method for the detection and monitoring of prostate cancer over the past decades. Despite the indications against its use in massive population screening, PSA still remains the best studied biomarker for prostate cancer and the detection of its different forms and incorporation in multiplexed designs with other biomarkers still remains a highly valuable indicator in the theranostics of prostate cancer. The latest developments in the use of nanomaterials towards the construction of PSA biosensors are reviewed hereby. The incorporation of gold nanoparticles, silica nanoparticles and graphene nanostructures to biosensing devices has represented a big leap forward in terms of sensitivity, stability and miniaturization. Both electrochemical and optical detection methods for the detection of PSA will be reviewed herein.

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“…absorption and scattering) properties of Au NPs have been used in different applications, such as scattering, dark field, and twophoton based optical imaging. [23][24][25] When Au is combined with up-conversion luminescent NPs, the scattering and absorption in the crossing visible area impairs the luminescence emission. It is proposed that all UCL peaks could be enhanced if the SPR peak would be tuned to the NIR region.…”

Section: Introductionmentioning

confidence: 99%

Up-Conversion Luminescence Properties of Lanthanide-Gold Hybrid Nanoparticles as Analyzed with Discrete Dipole Approximation

Mao

Parak

2018

Preprint

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Up-conversion nanoparticles (UCNP) under near-infrared (NIR) light irradiation have been well investigated in the field of bio-imaging. However, the low up-conversion luminescence (UCL) intensity limits applications. Plasmatic modulation has been proposed as an effective tool to adjust the luminescence intensity and lifetime. In this study discrete dipole approximation (DDA) was explored concerning guiding the design of UCNP@mSiO2-Au structures with enhanced UCL intensity. The extinction effects of gold shells could be changed by adjusting the distance between the UCNPs and the Au NPs by synthesized tunable mesoporous silica (mSiO2) spacers. Enhanced UCL was obtained under 808 nm irradiation. Theoretical predictions could not be demonstrated to full extend by experimental data, indicating that better models for simulation need to better take into account inhomogeneities in particle morphologies.

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Metal-enhanced fluorescent dye-doped silica nanoparticles and magnetic separation: A sensitive platform for one-step fluorescence detection of prostate specific antigen

Cited by 87 publications

References 45 publications

Review: Applications of surface-enhanced fluorescence (SEF) spectroscopy in bio-detection and biosensing

Review: Applications of surface-enhanced fluorescence (SEF) spectroscopy in bio-detection and biosensing

Detection and monitoring prostate specific antigen using nanotechnology approaches to biosensing

Up-Conversion Luminescence Properties of Lanthanide-Gold Hybrid Nanoparticles as Analyzed with Discrete Dipole Approximation

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