Metal Elements, Organic Agents in a Herbal Remedy, Species Thymi Composita, and Its Drug-Constituents

Szentmihályi, Klára; May, Zoltán; Then, M.; Böszörményi, Andrea; Balázs, Andrea; Lemberkovics, Éva; Marczal, G.; Szöke, Éva

doi:10.17628/ecb.2012.1.14-21

Cited by 2 publications

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“…For example, the total Cr content of the thyme ( Thymi vulgaris herba , Bionit Ltd., Kistarcsa, Hungary) measured by Kovács et al [ 3 ] was 12,05 l g/100 g, and the value published by Fischer [ 4 ] was 10,00 l g/100 g. On the other hand, value reported by Garcia et al [ 5 ] was 85 l g/100 g. The elemental content of thyme depends mainly on the growing location because it can accumulate large quantities of elements. Based on preliminary studies ( n = 3) described by Szentmihályi et al [ 6 ], the EIs of drug components and Species thymi composita (mg/kg dry weight) are quite different. For example, Cr level was relatively high (11.51 ± 0.24 mg/kg) [ 6 ] in comparison to other elemental impurities.…”

Section: Introductionmentioning

confidence: 99%

“…Based on preliminary studies ( n = 3) described by Szentmihályi et al [ 6 ], the EIs of drug components and Species thymi composita (mg/kg dry weight) are quite different. For example, Cr level was relatively high (11.51 ± 0.24 mg/kg) [ 6 ] in comparison to other elemental impurities. It should be underlined that Cr is an “enigmatic” element.…”

Section: Introductionmentioning

confidence: 99%

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The Comprehensive Toxicological Assessment of Total Chromium Impurities in Traditional Herbal Medicinal Product with Thymi herba (Thymus vulgaris L. and Thymus zygis L.) Available in Pharmacies in Poland: Short Communication

Jurowski

Fołta

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et al. 2021

Biol Trace Elem Res

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Scientific reports about elemental impurities in final pharmaceutical products are essential from a regulatory point of view; unfortunately, there is a lack of studies about this important toxicological topic. The aim of our short communication was determination of total Cr impurities in traditional herbal medicinal products (THMP) with Thymi herba (Thymus vulgaris L. and Thymus zygis L.) available in Polish pharmacies (n = 6, because only six manufacturers produce this kind of pharmaceutical products in Poland). The total content of Cr impurities was determined by atomic absorption spectrometry using electrothermal atomization (ETAAS). Applied comprehensive toxicological risk assessment was based on three main tiers: Tier 1, the comparison of raw results as total Cr impurities profile (metal per L of THMP) with ICH Q3D guideline standards; Tier 2, the estimation of total Cr exposure with a single dose; and Tier 3, the estimation of total Cr daily exposure. We confirmed that total Cr impurities were present in all analyzed THMP with thymi herba (the observed level was below 6.0 µg/L). Total Cr concentration in a single dose can be deceptively high in comparison to the raw results but is not a threat to patients (20.15–63.45 ng/single dose). Moreover, the estimation of total Cr daily exposure shows that all analyzed THMP are characterized by daily dose (40.30–181.41 ng/day) below PDE value (10,700 mg/day); hence, all products meet the standards of ICH Q3D elemental impurities guideline.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

The Comprehensive Toxicological Assessment of Total Chromium Impurities in Traditional Herbal Medicinal Product with Thymi herba (Thymus vulgaris L. and Thymus zygis L.) Available in Pharmacies in Poland: Short Communication

Jurowski

Fołta

Tatar

et al. 2021

Biol Trace Elem Res

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Gyógynövénykivonatok fémelemtartalom-vizsgálatának jelentősége adjuváns terápiában

Szentmihályi

2018

Orvosi Hetilap

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The consumption of herbal teas is becoming more and more popular nowadays both as luxury foods and a complementary part of medical therapy. Beside the organic agents of medicinal plants, the presence of inorganic ions is also relevant in exerting the favorable pharmacological effect. The author briefly summarizes the importance of some essential metal ions and their quantitative values in teas applied in the adjuvant therapy of diabetes and used as diuretics. The common feature of teas used in diabetes is that they contain a measurable amount of chromium and the concentration of most essential elements (such as K, Mg, Mn and Zn) is significant, which can be considered as a mineral source for some metal ions. Diuretic herbs have an outstanding K content, but from the point of view of diuresis, the large K/Na molar ratio above 50 is relevant. Orv Hetil. 2018; 159(18): 713-719.

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Metal Elements, Organic Agents in a Herbal Remedy, Species Thymi Composita, and Its Drug-Constituents

Cited by 2 publications

References 0 publications

The Comprehensive Toxicological Assessment of Total Chromium Impurities in Traditional Herbal Medicinal Product with Thymi herba (Thymus vulgaris L. and Thymus zygis L.) Available in Pharmacies in Poland: Short Communication

The Comprehensive Toxicological Assessment of Total Chromium Impurities in Traditional Herbal Medicinal Product with Thymi herba (Thymus vulgaris L. and Thymus zygis L.) Available in Pharmacies in Poland: Short Communication

Gyógynövénykivonatok fémelemtartalom-vizsgálatának jelentősége adjuváns terápiában

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