Metal electrodes in plastic microfluidic systems

Schrott, Walter; Svoboda, Miloš; Slouka, Zdeněk; Šnita, Dalimil

doi:10.1016/j.mee.2009.01.001

Cited by 20 publications

(17 citation statements)

References 15 publications

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“…The electrodes are not covered by any material and form a planar surface together with the PMMA plate. The microelectrodes were fabricated by a multistep procedure utilizing a sacrificed metal layer introduced by Schrott et al 28 All electrodes were 200 μm wide and were led underneath the entire fluidic chamber. In the eight-electrode arrangement, the gap between adjacent electrodes was 500 μm (Figure 1(b)).…”

Section: B Microchip Fabricationmentioning

confidence: 99%

Oscillatory motion of water droplets in kerosene above co-planar electrodes in microfluidic chips

et al. 2014

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We experimentally observed oscillatory motion of water droplets in microfluidic systems with coplanar microelectrodes under imposed DC electric fields. Two-electrode arrangement with no bipolar electrode and eight-electrode arrangement with six bipolar microelectrodes were investigated. Kerosene was used as the continuous phase. We studied the dependences of the oscillation frequency on the electric field intensity and ionic strength of the water phase. We found that the electric field dependence is strongly nonlinear and discussed possible reasons of this phenomenon, e.g., the droplet deformation at electrode edges that affects the charge transfer between the electrode and droplet or the interplay between the Coulomb force on free charge and the dielectrophoretic force. Our experiments further revealed that the oscillation frequency decreases with growing salt concentration in the two-electrode arrangement, but increases in the eight-electrode arrangement, which was attributed to surface tension related processes and electrochemical processes on the bipolar electrodes. Finally, we analyzed the effects of the electric field on the oscillatory motion by means of a simplified mathematical model. It was shown that the electric force imposed on the droplet charge is the key factor to induce the oscillations and the dielectrophoretic force significantly contributes to the momentum transfer at the electrode edges. For the same electric field strength, the model is able to predict the same oscillation frequency as that observed in the experiments.

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Section: B Microchip Fabricationmentioning

confidence: 99%

Oscillatory motion of water droplets in kerosene above co-planar electrodes in microfluidic chips

et al. 2014

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“…The presented results document its application for detection of short-time reversal of the near-wall flow, delimitation of flow-recirculation zones, investigation of the near-wall turbulence, or detection of moving bubbles. The first results obtained with new sensors fabricated by the method of a sacrificed substrate [10] proved to be a reliable platform for the application of electrodiffusion technique in microfluidics.…”

Section: Discussionmentioning

confidence: 99%

“…Then a new technology of sensor fabrication [10] is introduced and the results of first test measurements carried out with such photolithographymade sensors in microchannel flows are presented.…”

Section: Introductionmentioning

confidence: 99%

Application of the electrodiffusion method for near-wall flow diagnostics

Tihon

2014

EPJ Web of Conferences

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Abstract. The electrodiffusion method is presented as a measuring technique suitable for the flow measurement done in close proximity of the wall, thus in the region difficultly accessible by standard anemometric techniques (e.g. PIV, LDA). The experimental results obtained in different flow configurations (backward-facing step flow, wavy film flow, turbulent channel flow, rising Taylor bubbles) document application capabilities of this technique, e.g. for mapping of wall shear stresses, delimitation of stable flowrecirculation zones, detection of short-time reversal of the near-wall flow, investigation of the near-wall turbulence, or detection of moving fluid particles. A new technology of sensor fabrication based on photolithography is introduced and possible applications of microsensors in microfluidic devices discussed.

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“…Therefore, state-of-the-art industrial fabrication processes, including hot embossing and injection molding, have been adopted for low-cost microdevice fabrication to meet the required production throughput as well as microdevice complexity (Roy et al, 2011(Roy et al, , 2015. However, the major disadvantage of plastic chips is the integration of biosensors (especially metal electrodes) with only a few processes being fit for industrial application (Schrott et al, 2009;Huang et al, 2010).…”

Section: Fabrication Methods and Materials Of Cell Chip Systemsmentioning

confidence: 99%

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

et al. 2015

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The combination of microfabrication-based technologies with cell biology has laid the foundation for the development of advanced in vitro diagnostic systems capable of evaluating cell cultures under defined, reproducible, and standardizable measurement conditions. In the present review, we describe recent lab-on-a-chip developments for cell analysis and how these methodologies could improve standard quality control in the field of manufacturing cell-based vaccines for clinical purposes. We highlight in particular the regulatory requirements for advanced cell therapy applications using as an example dendritic cell-based cancer vaccines to describe the tangible advantages of microfluidic devices that overcome most of the challenges associated with automation, miniaturization, and integration of cell-based assays. As its main advantage, lab-on-a-chip (LoC) technology allows for precise regulation of culturing conditions, while simultaneously monitoring cell relevant parameters using embedded sensory systems. State-of-the-art lab-on-a-chip platforms for in vitro assessment of cell cultures and their potential future applications for cell-based strategies for cancer immunotherapy are discussed in the present review.

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Metal electrodes in plastic microfluidic systems

Cited by 20 publications

References 15 publications

Oscillatory motion of water droplets in kerosene above co-planar electrodes in microfluidic chips

Oscillatory motion of water droplets in kerosene above co-planar electrodes in microfluidic chips

Application of the electrodiffusion method for near-wall flow diagnostics

Automated, Miniaturized, and Integrated Quality Control-on-Chip (QC-on-a-Chip) for Cell-Based Cancer Therapy Applications

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