Metal‐DNA Nanocomplexes Enhance Chemo‐dynamic Therapy by Inhibiting Autophagy‐Mediated Resistance
Chao Gu,
Xueliang Liu,
Lei Luo
et al.
Abstract:Chemo‐dynamic therapy (CDT) based on the Fenton or Fenton‐like reaction has emerged as a promising approach for cancer treatment. However, autophagy‐mediated self‐protection mechanisms of cancer cells pose a significant challenge to the efficacy of CDT. Herein, we developed metal‐DNA nanocomplexes (DACs‐Mn) to enhance CDT via DNAzyme inhibition of autophagy. Specifically, Mn‐based catalyst in DACs‐Mn was used to generate highly hydroxyl radicals (⋅OH) that kill cancer cells, while the ATG5 DNAzyme incorporated… Show more
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