Metal complexes of Schiff base: Preparation, characterization and antibacterial activity

Yousif, Emad; Majeed, Ahmed; Al-Sammarrae, Khulood W.; Salih, Nadia; Salimon, Jumat; Abdullah, Bashar Mudhaffar

doi:10.1016/j.arabjc.2013.06.006

Cited by 192 publications

(106 citation statements)

References 8 publications

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“…The prominent IR bands recorded for the Schiff bases and complexes with probable assignments are given in Table . Schiff bases 1 – 4 exhibit medium bands in the range 1630–1624 cm −1 attributed to azomethine linkage (─CH═N─) and these bands are lowered in wavenumber by 15–25 cm −1 for their corresponding metal complexes demonstrating donation of lone pair of electrons of nitrogen atom to the central metal ions . Appearance of strong bands in the vicinity of 1224–1211 cm −1 , assigned to v (C─F) stretching vibrations, confirmed the presence of C─F bond in all the reported compounds.…”

Section: Resultssupporting

confidence: 55%

Some divalent metal(II) complexes of salicylaldehyde‐derived Schiff bases: Synthesis, spectroscopic characterization, antimicrobial and in vitro anticancer studies

Devi

Yadav

Kumar

et al. 2018

Applied Organom Chemis

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Mononuclear transition metal(II) complexes of the type M(L)2⋅2H2O (where M = Co, Ni, Cu, Zn) have been synthesized from uninegative Schiff base ligands (HL1–HL4) designed by condensation of 4‐fluorobenzylamine with 2‐hydroxy‐1‐naphthaldehyde/3,5‐dichlorosalicylaldehyde/3,5‐dibromosalicylaldehyde/3‐bromo‐5‐chlorosalicylaldehyde. The compounds were successfully characterized using spectroscopic and physiochemical methods together with elemental analysis. Spectroscopic elucidation indicates a monobasic bidentate nature of ligands coordinated via deprotonated phenolic oxygen and azomethine nitrogen atom which suggests an octahedral geometry around the central metal ions. The complexes and ligands were screened for their in vitro antimicrobial activity against bacterial and fungal strains, the zinc(II) complexes being more active against the tested microbial strains. Further, the metal complexes were found to be more active than the uncomplexed ligands due to chelation process and, moreover, the complexes were more active against fungal strains than bacterial strains. Cytotoxic activities of all compounds were evaluated towards human alveolar adenocarcinoma epithelial cell line (A549), human breast adenocarcinoma cell line (MCF7), human prostate cancer cell line (DU145) and one normal human lung cell line (MRC‐5) using MTT colorimetric assay with doxorubicin as a standard. The zinc complexes were most active against the cancer cell lines and also found to be less toxic against MRC‐5 normal cell line than standard doxorubicin.

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Section: Resultssupporting

confidence: 55%

Some divalent metal(II) complexes of salicylaldehyde‐derived Schiff bases: Synthesis, spectroscopic characterization, antimicrobial and in vitro anticancer studies

Devi

Yadav

Kumar

et al. 2018

Applied Organom Chemis

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“…The resistance mechanisms therefore depend on which specific pathways are inhibited by the drugs and the alternative ways available for those pathways that the organisms can modify to get a way around in order to survive. Resistance can be described in two ways: (a) intrinsic or natural whereby microorganisms naturally do not posses target sites for the drugs and therefore the drug does not affect them or they naturally have low permeability to those agents because of the differences in the chemical nature of the drug and the microbial membrane structures especially for those that require entry into the microbial cell in order to effect their action or (b) acquired resistance whereby a naturally susceptible microorganism acquires ways of not being affected by the drug [44]. …”

Section: Applications Antibacterial Activity Of Complexes In Agar Mediummentioning

confidence: 99%

Synthesis of Co(II) and Cr(III) salicylidenic Schiff base complexes derived from thiourea as precursors for nano-sized Co3O4 and Cr2O3 and their catalytic, antibacterial properties

Kafi‐Ahmadi

Shirmohammadzadeh

2017

J Nanostruct Chem

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This study focuses on the synthesis of Co(II) and Cr(III) Schiff base complexes obtained from thiourea. The complexes were synthesized by template method and characterized by elemental analysis (CHNS), FT-IR, UVvis spectroscopy, conductivity measurement and magnetic moment. The spectroscopic studies suggested the octahedral and square-pyramidal structures for Co(II) and Cr(III) complexes, respectively. Then the complexes were used as precursors for preparation of Co 3 O 4 and Cr 2 O 3 nanoparticles via solid-state thermal decomposition without using a catalyst, toxic solvent, template or surfactant and complicated equipment, which makes it efficient, one-step, simple and environment-friendly. The chemical structure of the metal oxides is studied by FT-IR, XRD and SEM. To investigate the applications of the synthesized complexes, in the next step, the complexes were screened for antibacterial activity against clinically important bacteria such as Escherichia coli, Staphylococcus aureus, and Bacillus subtilis. The Cr(III) and Co(II) complexes showed good biological activity against all the tested bacteria. Also, the catalytic activities of the complexes were studied in toluene using non-toxic hydrogen peroxide as the oxidant. The results showed that Co(II) complex has catalytic activity for oxidation of toluene, but Cr(III) complex did not show any catalytic activity.

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“…These distinct features allow mesoionic compounds to efficiently cross cellular membranes, leading to good oral absorption, bioavailability and strong unique interactions with biological molecules (e.g., DNA, proteins, etc.) Furthermore, the high in vivo stability and low toxicity for higher organisms are also attributed to the 1,3,4-thiadiazole ring [20,33,34]. The thiadiazole ring is a bioisostere of the pyrimidine and pyridazine rings.…”

Section: Nitrogen-containing Heterocycles and Thiadiazole Ring In Biomentioning

confidence: 99%

“…In addition, nitrogen-containing heterocycles are important targets for medicinal chemistry, as they are found in more than half of the commercially available drugs and can also act as versatile intermediates in the synthesis of complex products that exhibit outstanding biological activities [15]. Furthermore, the high in vivo stability and low toxicity for higher organisms are also attributed to the 1,3,4-thiadiazole ring [20,33,34]. Currently, there are approximately 90 drugs approved for use in the treatment of nine human viral infections caused by human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus (HSV), Influenza virus, human cytomegalovirus (HCMV), varicella-zoster virus (VZV), respiratory syncytial virus (RSV) and human papillomavirus [18].…”

mentioning

confidence: 99%

Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections

Şerban

2020

Molecules

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Viral infections have resulted in millions of victims in human history. Although great efforts have been made to find effective medication, there are still no drugs that truly cure viral infections. There are currently approximately 90 drugs approved for the treatment of human viral infections. As resistance toward available antiviral drugs has become a global threat to health, there is an intrinsic need to identify new scaffolds that are useful in discovering innovative, less toxic and highly active antiviral agents. 1,3,4-Thiadiazole derivatives have been extensively studied due to their pharmacological profile, physicochemical and pharmacokinetic properties. This review provides an overview of the various synthetic compounds containing the 2-amino-1,3,4-thiadiazole moiety that has been evaluated for antiviral activity against several viral strains and could be considered possible prototypes for the development of new antiviral drugs.Molecules 2020, 25, 942 2 of 22 due to the ability of viruses to undergo rapid mutations, the mechanisms involved in developing resistance to antiviral drugs are activated in most cases [1,3]. As resistance toward antiviral drugs is becoming a global health threat, there is an intrinsic need to identify new scaffolds that are useful in discovering innovative, less toxic and highly active antiviral agents [3,6,7]. Nitrogen-Containing Heterocycles and Thiadiazole Ring in Biology and Medicinal ChemistryNitrogen-containing heterocycles are widely distributed in nature and are essential in vegetal and animal metabolism. They are found in nucleic acids, vitamins, antibiotics, alkaloids, etc. [8][9][10][11][12][13][14]. In addition, nitrogen-containing heterocycles are important targets for medicinal chemistry, as they are found in more than half of the commercially available drugs and can also act as versatile intermediates in the synthesis of complex products that exhibit outstanding biological activities [15]. Most of the nitrogen-containing heterocyclic compounds exhibit better biological activity than non-nitrogen compounds [12,16,17]. Currently, there are approximately 90 drugs approved for use in the treatment of nine human viral infections caused by human immunodeficiency virus (HIV), hepatitis B virus (HBV), hepatitis C virus (HCV), herpes simplex virus (HSV), Influenza virus, human cytomegalovirus (HCMV), varicella-zoster virus (VZV), respiratory syncytial virus (RSV) and human papillomavirus [18]. Most of these drugs (e.g., acyclovir, cidofovir, idoxuridine, nevirapine, pleconaril, ribavirin, etc.) are nitrogen heterocycle molecules [3,19].Five-membered aromatic systems with three heteroatoms at symmetrical positions, such as the 1,3,4-thiadiazole ring, have been extensively studied due to their pharmacological profile and physicochemical and pharmacokinetic properties. 1,3,4-Thiadiazole derivatives are known as compounds having significant and diverse biological activities such as antibacterial, antifungal, antitubercular [20], analgesic and anti-inflammatory [21,22], antidepr...

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Metal complexes of Schiff base: Preparation, characterization and antibacterial activity

Cited by 192 publications

References 8 publications

Some divalent metal(II) complexes of salicylaldehyde‐derived Schiff bases: Synthesis, spectroscopic characterization, antimicrobial and in vitro anticancer studies

Some divalent metal(II) complexes of salicylaldehyde‐derived Schiff bases: Synthesis, spectroscopic characterization, antimicrobial and in vitro anticancer studies

Synthesis of Co(II) and Cr(III) salicylidenic Schiff base complexes derived from thiourea as precursors for nano-sized Co3O4 and Cr2O3 and their catalytic, antibacterial properties

Synthetic Compounds with 2-Amino-1,3,4-Thiadiazole Moiety Against Viral Infections

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