Metal complexes of ‘Heena’ (2-hydroxy-1,4-naphthoquinone): Synthesis, Characterization and anticancer activity

Mone, Nishigandha S.; Harihar, Shital; Salunke‐Gawali, Sunita; Satpute, Surekha K.; Patil, Apurva; Mokashi, Vivek; Jadhav, Mahesh; Butcher, Ray J.

doi:10.1016/j.ica.2022.121290

Cited by 6 publications

(3 citation statements)

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“…Various methods have been explored for the synthesis of tacrine and its analogues. Mollabagher et al 35 introduced a novel procedure for the synthesis of tacrine derivatives 21a-e, utilizing 2hydroxynaphthalene-1,4-dione (1), malononitrile (5), aldehydes 18a-e, and cyclohexanone (20) in a one-pot reaction, eliminating the need for intermediate separation. The use of Cu-MOF as a heterogeneous catalyst facilitated the formation of pyranic intermediates, followed by the addition of aluminum chloride in the Friedländer quinoline reaction, without interfering with the two catalysts involved.…”

Section: Tacrine Derivativesmentioning

confidence: 99%

“…16 17 18 19 The versatility of 2-hydroxy-1,4-naphthoquinone as a building block in organic synthesis has further expanded its potential for the development of novel compounds and therapeutic agents. 20–22…”

Section: Introductionmentioning

confidence: 99%

“…[16][17][18][19] The versatility of 2-hydroxy-1,4-naphthoquinone as a building block in organic synthesis has further expanded its potential for the development of novel compounds and therapeutic agents. [20][21][22] Recent efforts have focused on the synthesis of new derivatives of 2-hydroxy-1,4-naphthoquinone. 23 The syntheses of such derivatives have been studied extensively, with many of the established methods involving multicomponent reactions.…”

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confidence: 99%

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Recent Advances in the Synthesis of 2-Hydroxy-1,4-naphthoquinone (Lawsone) Derivatives

Sagar,

Shankar,

Khanna

et al. 2023

SynOpen

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Lawsone, also known as 2-hydroxy-1,4-naphthoquinone, has been extensively studied and found to be a crucial precursor in the production of a diverse range of natural products like molecular scaffolds, which are highly sought after for biological research purposes. Due to its unique chemical composition, Lawsone has been utilized for over a century as a starting material for the synthesis of numerous biologically active molecules and materials, showcasing intriguing properties across a wide range of scientific and technological applications. Additionally, Lawsone has been widely used in organic synthesis processes, with its various applications. The recent advances in the synthesis of different scaffolds starting from Lawsone and their applications are being discussed in details in the current review covering the literature during the period of 2017-2023.

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Section: Tacrine Derivativesmentioning

confidence: 99%