Metal Complexes in Biology and Medicine the System Cadmium (II) / Iron (II) /Zinc (II) - Proline

Abstract

Metal ions are fundamental elements for the maintenance of the life span’ s of the humans, animals and plants. In coordination compound studies, a knowledge of the magnitude of the stability constants of complexes is necessary for preliminary quantitative treatment. Present work described method that involves the use of paper electrophoretic technique for the study of the equilibria in binary complex systems in solution. This method is based on the movement of a spot of metal ion in an electric field at various pHs of the background electrolyte. A plot of overall mobility of metal / complex ion versus pH was used to obtain information on the formation of binary complexes and to calculate their stability constants. The stability constant of the ML and ML2 complexes of cadmium (II) – proline,iron(II) – proline and zinc(II) – proline, have been found to be (4.61 ± 0.01; 3.04 ± 0.03), (4.21 ± 0.01; 2.89 ± 0.09) and (4.98 ± 0.02; 2.44 ± 0.05) (logarithm constant values), respectively at 35 ºC and ionic strength 0.1 mol L-1. The first and second stability constants follow the order zinc (II) >cadmium (II) > iron (II). Metal complexes can offer their action such as anti-inflammatory, antidiabetic, antimicrobial, anticancer and ant thyroid compounds. Metal based drugs bioactivity can be increase by metal chelation, which in turn increase their absorbance and stability.