Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N6-benzylaminopurine derivatives

Maloň, Michal; Trávnı́ček, Zdeněk; Maryško, M.; Zbořil, Radek; Mašláň, M.; Marek, Jaromı́r; Doležal, Karel; Rolčı́k, Jakub; Kryštof, Vladimı́r; Strnad, Miroslav

doi:10.1016/s0020-1693(01)00611-9

Cited by 43 publications

(19 citation statements)

References 22 publications

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“…A sharp band observed at 482 and 487 cm −1 ascribed to the Fe−O stretching vibrations in the complexes ] and , respectively. Similar results have also been confirmed and reported by other authors [21]. …”

Section: Resultssupporting

confidence: 93%

Fertility Regulation in Male Rats by Implemented Tetraazamacrocyclic Compounds of Iron(II): Synthetic, Spectroscopic, and Applied Aspects with Toxicological Screening

Chaudhary

Singh

2006

Bioinorganic Chemistry and Applications

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Antifertility and histopathological investigations were carried out on reproductive organs of male albino rats induced by tetraazamacrocyclic complexes of iron(II). The complexes were synthesized by the template condensation of 1,2-diaminoethane, 1,3-diaminopropane with succinic acid and phthalic acid in 2 : 2 molar ratios which are abbreviated as [(TAMLn)OAc] (n = 1 or 2 and TAMLn represents tetraazamacrocyclic ligand). The complexes have been characterized by elemental analysis, conductivity measurements, IR, and electronic spectra.

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Section: Resultssupporting

confidence: 93%

Fertility Regulation in Male Rats by Implemented Tetraazamacrocyclic Compounds of Iron(II): Synthetic, Spectroscopic, and Applied Aspects with Toxicological Screening

Chaudhary

Singh

2006

Bioinorganic Chemistry and Applications

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“…The proposed structure for 2 involves the dimeric core {Cu( μ -HL n ) 2 ( μ -Cl) 2 Cu} with the copper centres bridged by two μ -N3,N9 HL 2 molecules and two chlorides, with one terminal N9-coordinated HL 2 and one chloride bonded to each Cu(II) (Figure 6), as was analogically reported previously for [Cu 2 ( μ - n ClHL x ) 2 ( μ -Cl) 2 ( n ClLH x ) 2 Cl 2 ]·2H 2 O ( n ClHL x = N6-( n -chlorobenzyl)adenine; n = 2, 3) [28, 29]. …”

Section: Resultssupporting

confidence: 79%

SOD-Mimic Cu(II) Dimeric Complexes Involving Kinetin and Its Derivative: Preparation and Characterization

Novotná

Trávníček

Herchel

2012

Bioinorganic Chemistry and Applications

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Two SOD-mimic active dimeric Cu(II) chlorido complexes of the compositions [Cu2(μ-HL1)4Cl2]Cl2 (1) and [Cu2(μ-HL2)2(μ-Cl)2(HL2)2Cl2] · 4H2O (2) involving the cosmetologically relevant cytokinin kinetin (N6-furfuryladenine, HL1) and its derivative N6-(5-methylfurfuryl)adenine (HL2) have been synthesized and characterized by elemental analysis, infrared, and electronic spectroscopy, ESI+ mass spectrometry, conductivity and temperature dependence of magnetic susceptibility measurements, and thermogravimetric (TG) and differential thermal (DTA) analyses. The results of these methods, particularly the temperature dependence of magnetic susceptibility, showed the complexes to be dimeric with a strong antiferromagnetic exchange (J = −290 cm−1 for complex 1 and J = −160 cm−1 for 2). The complexes have been identified as auspicious SOD-mimics, as their antiradical activity evaluated by the in vitro SOD-mimic assay resulted in the IC50 values equal to 8.13 μM (1) and 0.71 μM (2).

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“…Bond lengths and angles in (I) are comparable with those found in similar singly protonated structures such as 6benzylaminopurin-3-ium bromide (Umadevi et al, 2001), 6-(3chlorobenzylamino)purin-3-ium chloride (Maloň et al, 2001), 6-(4-chlorobenzylamino)purin-3-ium perchlorate (Maloň et al, 2002), 6-(4-methoxybenzylamino)purin-3-ium chloride and 6-(3-methoxybenzylamino)purin-3-ium chloride monohydrate (Trá vníček et al, 2005). The shortest contact between two Cl À anions in (I) is 4.079 (1) Å , which is significantly shorter than the corresponding values found in 6-(3-chlorobenzylamino)purin-3-ium chloride [4.160 (1) Å ; Maloň et al, 2001], 6-(4-methoxybenzylamino)purin-3-ium chloride [5.157 (1) Å ; and 6-(3-methoxybenzylamino)purin-3-ium chloride [4.991 (5) Å ;Trá vníček et al, 2005]. Surprisingly, some of the electroneutral forms of 6-benzylaminopurine derivatives also demonstrate protonation at the N7 position, which is very rare for these compounds, e.g.…”

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confidence: 73%

6-(3-Bromobenzylamino)purin-3-ium chloride

Trávníček

Matiková-Maľarová

2006

Acta Cryst E

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Metal complexes as anticancer agents 2. Iron(III) and copper(II) bio-active complexes with N6-benzylaminopurine derivatives

Cited by 43 publications

References 22 publications

Fertility Regulation in Male Rats by Implemented Tetraazamacrocyclic Compounds of Iron(II): Synthetic, Spectroscopic, and Applied Aspects with Toxicological Screening

Fertility Regulation in Male Rats by Implemented Tetraazamacrocyclic Compounds of Iron(II): Synthetic, Spectroscopic, and Applied Aspects with Toxicological Screening

SOD-Mimic Cu(II) Dimeric Complexes Involving Kinetin and Its Derivative: Preparation and Characterization

6-(3-Bromobenzylamino)purin-3-ium chloride

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