Metal Complexes and Imprinted Polymers for Shape-Selective Catalysis

Mirata, Fosca; Resmini, Marina

doi:10.1007/978-3-319-50207-6_4

Cited by 1 publication

(1 citation statement)

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“…These MIPs mimic catalysis by hydrolases. On the other hand, oxidoreductase mimics have been synthesized by integrating metal ions or metal complexes into the polymer matrix of MIPs [9,100]. As described for enzyme electrodes, the measuring signal is generated by the indication of an electroactive product or the consumption of a cosubstrate-like oxygen or peroxide.…”

Section: Catalytically Active Mipsmentioning

confidence: 99%

How Reliable Is the Electrochemical Readout of MIP Sensors?

Yarman

Scheller

2020

Sensors

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Electrochemical methods offer the simple characterization of the synthesis of molecularly imprinted polymers (MIPs) and the readouts of target binding. The binding of electroinactive analytes can be detected indirectly by their modulating effect on the diffusional permeability of a redox marker through thin MIP films. However, this process generates an overall signal, which may include nonspecific interactions with the nonimprinted surface and adsorption at the electrode surface in addition to (specific) binding to the cavities. Redox-active low-molecular-weight targets and metalloproteins enable a more specific direct quantification of their binding to MIPs by measuring the faradaic current. The in situ characterization of enzymes, MIP-based mimics of redox enzymes or enzyme-labeled targets, is based on the indication of an electroactive product. This approach allows the determination of both the activity of the bio(mimetic) catalyst and of the substrate concentration.

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Section: Catalytically Active Mipsmentioning

confidence: 99%