Metal-coated microfluidic channels: An approach to eliminate streaming potential effects in nano biosensors

Lee, Jieun; Wipf, Mathias; Mu, Luye; Adams, Chris J.; Hannant, Jennifer; Reed, Mark A.

doi:10.1016/j.bios.2016.08.065

Cited by 16 publications

(12 citation statements)

References 41 publications

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“…These nanobiosensors offer significant improvements in selectivity, speed and sensitivity compared to traditional chemical and biological methods. Nanosensors can be used for determination of microbes or pathogens, contaminants and food freshness (Joyner and Kumar 2015; Bazin et al 2017;Bhat et al 2017;Kurbanoglu et al 2017;Lee et al 2017;Ray et al 2017). A detection technique that takes less time and that can give results within a few hours, that is simple, portable and accurate and does not require any complicated technique for operation so that even a simple farmer can use the portable system.…”

Section: Nanobiosensorsmentioning

confidence: 99%

Nanobiotechnology for Plants

Abdalla¹,

Ragab

Fári

et al. 2019

EBSS

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N ANOTECHNOLOGY has been revolutionized penetrating all sectors in our life through the nanoscience as an essential science for a wide range of technologies. Amazing achievements resulted from this nanotechnology including all agricultural fields such as plant nutrition and crop productivity, energy sector, food sector, and plant biotechnology. A conjugation between plant biotechnology and nanotechnology has been produced an important science called plant bio-nanotechnology. Several fields have been invaded through different nanobiotechnology applications in agriculture including (1) the nanotechnology of encapsulated agro-chemicals, (2) the monitoring of different environmental stresses and crop conditions using nanobiosensors, (3) the improvement of crop production and ameliorating plants against diseases and (4) solution several environmental problems. The crop productivity also could be improved using some new agro-chemicals (e.g., nanofertilizers and nanopesticides). These agro-chemicals are very effective in delivering encapsulating nanomaterials and then enhancement the productivity of crops as well as the suppress plant pests and diseases and protecting the environment from pollution. On the other hand, nanoparticles could enter the food chain via different nano-agrochemicals or nano-processed foods. Therefore, many approaches including uptake of nanoparticles by plants, entry and bio-distribution of nanoparticles into the food chain are needed before using of different bionanotechnological tools in agro-production sector. Further new regulations should be created or rebuilt for new approaches in plant bionanotechnology. Therefore, this review will focus on our needs and risks in the plant nanobiotechnology.

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Section: Nanobiosensorsmentioning

confidence: 99%

Nanobiotechnology for Plants

Abdalla¹,

Ragab

Fári

et al. 2019

EBSS

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“…When the Au surfaces are modified with AUT and MDA, the droplet charges increase. Metal‐coated microfluidic channels can be used to suppress the streaming potential and eliminate the noise of the biosensor due to the low‐stream potential of metals. The zeta potential of different substrates was investigated.…”

Section: Resultsmentioning

confidence: 99%

Engineering of Droplet Charges in Microfluidic Chips

Ruan

et al. 2020

Adv Eng Mater

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Droplet‐based technologies, which utilize the surface charge characterization of droplets, are used in fluorescence‐activated cell sorting and energy harvesting. Herein, the influence of droplet charges on microchips is investigated via surface engineering. An electrical field is applied to deflect the droplets in a microchannel, thereby enabling a qualitative analysis of the droplet charge. In a glass polydimethylsiloxane (PDMS)‐boned microchip, the droplet charge decreases when the microchannel is changed from a single‐sided to a three‐sided rectangular microstructure. When the ionic concentration of the droplet increases from 1 μm to 10 mm, droplet charges decrease by ≈78%. Meanwhile, a Au film is patterned in the microchannel, and 11‐aminoundecanethiol hydrochloride (AUT) and 12‐mercaptododecanoic acid (MDA) are modified to modulate the Au surface characterization. Compared with the glass–PDMS‐bonded microchannel, the Au film can suppress the streaming potential to decrease the droplet charges. After modification with MDA and AUT, the droplet charges increase. Therefore, the microchannel structures, ionic concentration, and substrate surface properties can be utilized to modulate the droplet charges, which can be widely used in droplet‐based energy harvesting and biological and chemical sample sorting.

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“…Panel C shows the statistical analysis of all local minima and maxima that correspond to the droplets at any fixed concentrations of the reactants. In order to eliminate the effect of the streaming potential, solutions can be found elsewhere in the literature [51]. In our case, the quantitative subtraction of the effect was the solution.…”

Section: Fet Monitoring Of β-Galactosidase Assaymentioning

confidence: 99%

Nanosensors-Assisted Quantitative Analysis of Biochemical Processes in Droplets

et al. 2020

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Here, we present a miniaturized lab-on-a-chip detecting system for an all-electric and label-free analysis of the emulsion droplets incorporating the nanoscopic silicon nanowires-based field-effect transistors (FETs). We specifically focus on the analysis of β-galactosidase e.g., activity, which is an important enzyme of the glycolysis metabolic pathway. Furthermore, the efficiency of the synthesis and action of β-galactosidase can be one of the markers for several diseases, e.g., cancer, hyper/hypoglycemia, cell senescence, or other disruptions in cell functioning. We measure the reaction and reaction kinetics-associated shift of the source-to-drain current Isd in the system, which is caused by the change of the ionic strength of the microenvironment. With these results, we demonstrate that the ion-sensitive FETs are able to sense the interior of the aqueous reactors; thus, the conjunction of miniature nanosensors and droplet-based microfluidic systems conceptually opens a new route toward a sensitive, optics-less analysis of biochemical processes.

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Metal-coated microfluidic channels: An approach to eliminate streaming potential effects in nano biosensors

Cited by 16 publications

References 41 publications

Nanobiotechnology for Plants

Nanobiotechnology for Plants

Engineering of Droplet Charges in Microfluidic Chips

Nanosensors-Assisted Quantitative Analysis of Biochemical Processes in Droplets

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