Metal cations promote α-dicarbonyl formation in glucose-containing peritoneal dialysis fluids

Gensberger‐Reigl, Sabrina; Auditore, Andrea; Huppert, Jochen; Pischetsrieder, Monika

doi:10.1007/s10719-020-09964-6

Cited by 3 publications

(2 citation statements)

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“…Glucosone is formed by the oxidation of glucose 20 , 21 . Recently, it was shown that traces of redox-active metal ions, such as iron(II), can promote the formation of the oxidized GDP glucosone and, to a lesser extent, also glyoxal and MGO 22 . The concentrations of 3-DG, 3-DGal, and 3,4-DGE, which are formed by non-oxidative mechanisms 2 were not affected by metal ions 22 .…”

Section: Discussionmentioning

confidence: 99%

“…Recently, it was shown that traces of redox-active metal ions, such as iron(II), can promote the formation of the oxidized GDP glucosone and, to a lesser extent, also glyoxal and MGO 22 . The concentrations of 3-DG, 3-DGal, and 3,4-DGE, which are formed by non-oxidative mechanisms 2 were not affected by metal ions 22 . Thus, traces of metal ions from raw materials or production equipment may be responsible for the formation of glucosone during the storage of double-chamber PDFs.…”

Section: Discussionmentioning

confidence: 99%

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Degradation and de novo formation of nine major glucose degradation products during storage of peritoneal dialysis fluids

Gensberger‐Reigl

Weigel

Stützer

et al. 2022

Sci Rep

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Reactive glucose degradation products (GDPs) are formed during heat sterilization of glucose-containing peritoneal dialysis fluids (PDFs) and may induce adverse clinical effects. Long periods of storage and/or transport of PDFs before use may lead to de novo formation or degradation of GDPs. Therefore, the present study quantified the GDP profiles of single- and double-chamber PDFs during storage. Glucosone, 3-deoxyglucosone (3-DG), 3-deoxygalactosone (3-DGal), 3,4-dideoxyglucosone-3-ene (3,4-DGE), glyoxal, methylglyoxal (MGO), acetaldehyde, formaldehyde, and 5-hydroxymethylfurfural (5-HMF) were quantified by two validated UHPLC-DAD methods after derivatization with o-phenylenediamine (dicarbonyls) or 2,4-dinitrophenylhydrazine (monocarbonyls). The PDFs were stored at 50 °C for 0, 1, 2, 4, 13, and 26 weeks. The total GDP concentration of single-chamber PDFs did not change considerably during storage (496.6 ± 16.0 µM, 0 weeks; 519.1 ± 13.1 µM, 26 weeks), but individual GDPs were affected differently. 3-DG (− 82.6 µM) and 3-DGal (− 71.3 µM) were degraded, whereas 5-HMF (+ 161.7 µM), glyoxal (+ 32.2 µM), and formaldehyde (+ 12.4 µM) accumulated between 0 and 26 weeks. Acetaldehyde, glucosone, MGO, and 3,4-DGE showed time-dependent formation and degradation. The GDP concentrations in double-chamber fluids were generally lower and differently affected by storage. In conclusion, the changes of GDP concentrations during storage should be considered for the evaluation of clinical effects of PDFs.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Degradation and de novo formation of nine major glucose degradation products during storage of peritoneal dialysis fluids

Gensberger‐Reigl

Weigel

Stützer

et al. 2022

Sci Rep

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Bis(alaninato)iron(II) complexes as molecular scaffolds for the generation of N,N-di-glycated alanine derivatives in the presence of glucose

Kim

Yaylayan

2022

Food Chemistry

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Qualitative and Quantitative Profiling of Fructose Degradation Products Revealed the Formation of Thirteen Reactive Carbonyl Compounds and Higher Reactivity Compared to Glucose

Ohno,

Auditore,

Gensberger-Reigl

et al. 2024

J. Agric. Food Chem.

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Fructose occurs in foods and as a metabolite in vivo. It can be degraded, leading to the formation of reactive carbonyl compounds, which may influence food properties and have an impact on health. The present study performed an in-depth qualitative and quantitative profiling of fructose degradation products. Thus, the α-dicarbonyl compounds 3-deoxyglucosone, glucosone, methylglyoxal, glyoxal, hydroxypyruvaldehyde, threosone, 3-deoxythreosone, and 1-desoxypentosone and the monocarbonyl compounds formaldehyde, acetaldehyde, glycolaldehyde, glyceraldehyde, and dihydroxyacetone were detected in fructose solutions incubated at 37 °C. Quantitative profiling after 7 days revealed 4.6–271.6-fold higher yields of all degradation products from fructose compared to glucose. Except for 3-deoxyglucosone, the product formation appeared to be metal dependent, indicating oxidative pathways. CaCl2 and MgCl2 partially reduced fructose degradation. Due to its high reactivity compared to glucose, particularly toward metal-catalyzed pathways, fructose may be a strong contributor to sugar degradation and Maillard reaction in foods and in vivo.

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Metal cations promote α-dicarbonyl formation in glucose-containing peritoneal dialysis fluids

Cited by 3 publications

References 40 publications

Degradation and de novo formation of nine major glucose degradation products during storage of peritoneal dialysis fluids

Degradation and de novo formation of nine major glucose degradation products during storage of peritoneal dialysis fluids

Bis(alaninato)iron(II) complexes as molecular scaffolds for the generation of N,N-di-glycated alanine derivatives in the presence of glucose

Qualitative and Quantitative Profiling of Fructose Degradation Products Revealed the Formation of Thirteen Reactive Carbonyl Compounds and Higher Reactivity Compared to Glucose

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