Metal binding to a zinc-finger peptide: a comparison between solution and the gas phase

Berezovskaya, Yana; Armstrong, Craig T.; Boyle, Aimee L.; Porrini, Massimiliano; Woolfson, Derek N.; Barran, Perdita E.

doi:10.1039/c0cc02445g

Cited by 27 publications

(24 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In addition, an exhaustive review focused on the mechanisms of metal ion-peptide interaction was published in 2006 [101]. Intensive study of metal ion interactions with oligopeptides covers both synthetic as well as naturally occurred oligopeptides [104][105][106][107].…”

Section: Metal-oligopeptides Interactionmentioning

confidence: 99%

From Amino Acids to Proteins as Targets for Metal-based Drugs

Zítka¹,

Ryvolová²,

Hubálek³

et al. 2012

CDM

View full text Add to dashboard Cite

Metallomics and metalloproteomics are emerging fields addressing the role, uptake, transport and storage of trace metals ions both toxic and essential for an organism. Research areas related to the understanding of the mechanisms of life processes associated to metals are covered. Similarly to the genome and proteome terms, metallome was introduced to refer to metalloproteins, metalloenzymes and other metal-containing biomolecules in a biological system. This review aims to give an overview of metal ions behaviour in organisms. The interactions of metals with biomolecules such as amino acids, peptides and protein are the main focus. Special attention is paid to the application of nanotechnology-based techniques using these interactions for medical purposes such as diagnostics, imaging and therapy.

show abstract

Section: Metal-oligopeptides Interactionmentioning

confidence: 99%

From Amino Acids to Proteins as Targets for Metal-based Drugs

Zítka¹,

Ryvolová²,

Hubálek³

et al. 2012

CDM

View full text Add to dashboard Cite

show abstract

“…Since mass of AD-MAH-RhB changed after conjugated with metal ions [32,33], mass spectroscopy was carried out to investigate the selectivity of AD-MAH-RhB for Hg 2? .…”

Section: Mechanism Studiesmentioning

confidence: 99%

Simultaneous detection and removal of metal ions based on a chemosensor composed of a rhodamine derivative and cyclodextrin-modified magnetic nanoparticles

Shi

Zeng

et al. 2014

J Mater Sci

View full text Add to dashboard Cite

A variety of chemosensors have been reported for detection of metal ions. However, the metal ions could not be separated and removed at the same time for the goal of water purification. This paper presents to detect and remove metal ions from aqueous solution simultaneously by a fluorescence chemosensor and functional magnetic nanoparticles. A novel probe adamantyl (AD)-maleic anhydride (MAH)-rhodamine B (RhB) was designed and synthesized from RhB, ethylene diamine, MAH, and AD. AD-MAH-RhB showed high selectivity and sensitivity to metal ions in aqueous solution. The sensing mechanism was explored by FTIR and mass spectra. The results suggested that AD-MAH-RhB could conjugate with metal ions and form the binding complexes with various stoichiometries of probe and metal ions. Moreover, b-cyclodextrin-modified magnetic nanoparticles (CD-MNP) were fabricated and used as host materials to form inclusion complex of CD-MNP and AD-MAH-RhB-metal ions. Then, the metal ions could be removed by an outer magnet, which were confirmed by fluorescent spectrum. The probe and CD-MNP had the great potential application for sewage treatment.

show abstract

“…[15][16][17][18][19][20][21][22][23][24][25][26] The binding mode of metal ions greatly influences the conformation of ligands 27,28 and vice versa. The change in the protein structure induced by metal binding may lead to functional [29][30][31][32][33][34][35] or pathogenic [36][37][38][39][40][41][42][43][44] complexes. The recognition of the importance of coordination isomers has opened a new era in metallopharmaceutical design.…”

Section: Introductionmentioning

confidence: 99%

Exploring the boundaries of direct detection and characterization of labile isomers – a case study of copper(ii)–dipeptide systems

et al. 2017

View full text Add to dashboard Cite

The investigation of the linkage isomers of biologically essential and kinetically labile metal complexes in aqueous solutions poses a challenge, as these microspecies cannot be separately studied. Therefore, derivatives are commonly used to initially determine the stability or spectral characteristics of at least one of the isomers. Here we directly detect the isomers, describe the metal ion coordination sphere, speciation and thermodynamic parameters by a synergistic application of temperature dependent EPR and CD spectroscopic measurements in copper(ii)-dipeptide systems including His-Gly and His-Ala ligands. The ΔH = (-23 ± 4) kJ mol value of the standard enthalpy change corresponding to the peptide-type to histamine-type isomerisation equilibrium of the [CuL] complex was corroborated by several techniques. The preferential coordination of the side-chains was observed at lower temperatures, whereas, metal-binding of the backbone atoms became favourable upon increasing temperature. This study exemplifies the necessity of using temperature dependent multiple methodologies for a reliable description of similar systems for upstream applications.

show abstract

Metal binding to a zinc-finger peptide: a comparison between solution and the gas phase

Cited by 27 publications

References 9 publications

From Amino Acids to Proteins as Targets for Metal-based Drugs

From Amino Acids to Proteins as Targets for Metal-based Drugs

Simultaneous detection and removal of metal ions based on a chemosensor composed of a rhodamine derivative and cyclodextrin-modified magnetic nanoparticles

Exploring the boundaries of direct detection and characterization of labile isomers – a case study of copper(ii)–dipeptide systems

Contact Info

Product

Resources

About