Metal‐binding Sites of N‐Acetylneuraminic Acid

Abstract

Sialic acid represents a group of thirty derivates of neuraminic acid with various substituents at the amino residue and the alcoholic hydroxy groups. We analysed the behaviour of the tetracoordinated metal ions palladium(II) and silicon(IV) against the most important derivative N-acetylneuraminic acid (NANA). The molecular 77 structures were assigned by a combined 1 H, 13 C and 29 Si NMR-spectroscopic approach. Despite the presence of many different functional groups, the coordination chemistry of NANA with Pd II follows established rules. Coordination via the N-acetyl-group -sterically impossible with Pd II -was realised with Si IV .