Metal based pharmacologically active complexes of Cu(II), Ni(II) and Zn(II): Synthesis, spectral, XRD, antimicrobial screening, DNA interaction and cleavage investigation

Raman, Natarajan; Mahalakshmi, Rajkumar; Arun, T.; Packianathan, Seemon; Rajkumar, R.

doi:10.1016/j.jphotobiol.2014.05.018

Cited by 36 publications

(11 citation statements)

References 38 publications

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“…Induction of phosphorylation of the Akt downstream effector glycogen synthase kinase 3 and thus proposed to serve as lead structures for developing antidiabetic drugs and useful tools for regulating glucose metabolism to name but a few examples [19]. Zn 2+ complexes are also known to exhibit antibacterial/antimicrobial, anticancer activities, interacting with DNA and the inducing protein aggregation [20][21][22][23][24][25][26].…”

Section: Highlightmentioning

confidence: 99%

A small-molecule acts as a ‘roadblock’ on DNA, hampering its fundamental processes

Kumar

2017

Journal of Inorganic Biochemistry

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DNA replication, RNA and protein synthesis are the most fundamental housekeeping processes involved in an organism's growth. Failure or dysregulation of these pathways are often deleterious to life. Therefore, selective inhibition of such processes can be crucial for the inhibition of the growth of any cell, including cancer cells, pathogenic bacteria or other deadly microbes. In the present study, a Zn complex is shown to act as a roadblock of DNA. The Zn complex inhibited DNA taq polymerase activity under the in vitro conditions of polymerase chain reaction (PCR). Under in vivo conditions, it readily crosses the cell wall of gram-negative bacteria (Escherichia coli), leading to the reduction of RNA levels as well as protein content. Growth of pathogenic bacteria (e.g., Staphylococcus aureus and Pseudomonas aeruginosa) was also significantly retarded. The Zn complex binds to the grooves of the DNA without inducing conformational changes or exhibiting chemical nuclease activity. To the best current knowledge, this is first coordination complex exhibiting a 'roadblock' property under both in vitro and in vivo conditions (show at all three levels - DNA, RNA and protein). The label-free approach used in this study may offer an alternative route towards fighting pathogenic bacteria or cancer cells by hampering fundamental cellular processes.

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Section: Highlightmentioning

confidence: 99%

A small-molecule acts as a ‘roadblock’ on DNA, hampering its fundamental processes

Kumar

2017

Journal of Inorganic Biochemistry

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“…The antibacterial screening of the ligand (3-MBTMPD) and its (1-4) metal complexes were performed against gram positive (B. Subtilis and S. Aureus) and gram negative bacteria (E. Coli and K. Pneumonia) by the disk diffusion method [54]. The activities of the compounds were compared with standard Ampicillin for antibacterial activity.…”

Section: Anti-bacterial Studiesmentioning

confidence: 99%

A Study on Spectro-Analytical Aspects, DNA – Interaction, Photo-Cleavage, Radical Scavenging, Cytotoxic Activities, Antibacterial and Docking Properties of 3 – (1 – (6 – methoxybenzo [d] thiazol – 2 – ylimino) ethyl) – 6 – methyl – 3H – pyran - 2, 4 – dione and its Metal Complexes

et al. 2015

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The focus of the present work is on the design, synthesis, characterization, DNA-interaction, photo-cleavage, radical scavenging, in-vitro cytotoxicity, antimicrobial, docking and kinetic studies of Cu (II), Cd (II), Ce (IV) and Zr (IV) metal complexes of an imine derivative, 3 - (1 - (6 - methoxybenzo [d] thiazol - 2 - ylimino) ethyl) - 6 - methyl - 3H - pyran - 2, 4 - dione. The investigation of metal ligand interactions for the determination of composition of metal complexes, corresponding kinetic studies and antioxidant activity in solution was carried out by spectrophotometric methods. The synthesized metal complexes were characterized by EDX analysis, Mass, IR, (1)H-NMR, (13)C-NMR and UV-Visible spectra. DNA binding studies of metal complexes with Calf thymus (CT) DNA were carried out at room temperature by employing UV-Vis electron absorption, fluorescence emission and viscosity measurement techniques. The results revealed that these complexes interact with DNA through intercalation. The results of in vitro antibacterial studies showed the enhanced activity of chelating agent in metal chelated form and thus inferring scope for further development of new therapeutic drugs. Cell viability experiments indicated that all complexes showed significant dose dependent cytotoxicity in selected cell lines. The molecular modeling and docking studies were carried out with energy minimized structures of metal complexes to identify the receptor to metal interactions.

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“…4. This method is useful to wind up with the structure, size, and strain of the synthesized compounds [59,60].…”

Section: Powder X-ray Diffraction and Surface Morphological Studies (mentioning

confidence: 99%

Theoretical and experimental studies on three new coordination complexes of Co(II), Ni(II), and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand

Kusmariya

Mishra

2015

J Mol Model

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Three mononuclear coordination complexes of Co(II), Ni(II), and Cu(II) have been synthesized from 2,4-dichloro-6-{(E)-[(5-chloro-2-sulfanylphenyl)imino]methyl}phenol ligand (H 2 L) obtained by simple condensation reaction of 3,5-dichloro-2-hydroxybenzaldehyde and 2-amino-4-chlorobenzenethiol and characterized by elemental analysis, spectral (FT-IR, electronic, and (1)H-NMR), molar conductance, thermal, SEM, PXRD, and fluorescence studies. The PXRD analysis and SEM-EDX micrographs show the crystalline nature of complexes. The domain size and the lattice strain of synthesized compounds have been determined according to Williamson-Hall plot. TG of the synthesized complexes illustrates the general decomposition pattern of the complexes. The ligand exhibits an interesting fluorescence property which is suppressed after complex formation. The Co(II) complex adopted a distorted octahedral configuration while Ni(II) and Cu(II) complexes showed square planar geometry around metal center. The geometry optimization, HOMO-LUMO, molecular electrostatic potential map (MEP), and spin density of synthesized compounds have been performed by density functional theory (DFT) method using B3LYP/6-31G and B3LYP/LANL2DZ as basis set. Graphical abstract Three new coordination complexes of Co(II), Ni(II) and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand.

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Metal based pharmacologically active complexes of Cu(II), Ni(II) and Zn(II): Synthesis, spectral, XRD, antimicrobial screening, DNA interaction and cleavage investigation

Cited by 36 publications

References 38 publications

A small-molecule acts as a ‘roadblock’ on DNA, hampering its fundamental processes

A small-molecule acts as a ‘roadblock’ on DNA, hampering its fundamental processes

Theoretical and experimental studies on three new coordination complexes of Co(II), Ni(II), and Cu(II) with 2,4-dichloro-6-{(E)-[(5-chloro-2 sulfanylphenyl)imino]methyl}phenol Schiff base ligand

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