Metal-Based Hybrid Nanoparticles as Radiosensitizers in Cancer Therapy

Xiao, Xiaohui; Xue, Peijun; Liu, Shaopeng; Zhang, Lechuan; Guan, Qingbao; Zhu, Jianliang; Tian, Xin

doi:10.1016/j.colcom.2018.01.004

Cited by 28 publications

(31 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…effectiveness when it comes to reducing adverse effects. This chemo-responsive effect is acquired by attaching a certain gate-keeper molecule on the pore that adjusts the drug release [110,[115][116][117][118][119]123]. Moreover, MSNs were considered suitable candidates owing to their pore and particle size, which can be adapted in a wide range, for example, from 2 to 50 nm and from 10 nm to microsized particles, which will allow for a more facile management of the "resident" molecules.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

“…However, the concern regarding the nanotoxicology of such nanocarriers is proportionally increasing owing to potential hazards they could cause, as nanoparticles are capable of permeating the skin [138]. delivery and, because of this, they can be decorated with different compounds in applications as biosensors for glucose monitoring [116,117,134].…”

Section: Cosmeticsmentioning

confidence: 99%

“…Moreover, diverse types of mesoporous materials were investigated as mesoporous carriers, including carbon, alumina, silica, titanium, iron oxide, and niobium oxide, but their biomedical applications were restricted owing to their limited biocompatibility. Some of them were already used as drug delivery systems, for example, mesoporous alumina with pores ranging from 2 to 7 nm was used as a model drug ibuprofen and mesoporous carbon nanoparticles encapsulating doxorubicin agent was investigated for chemo-photothermal therapy in breast cancer [ 110 , 115 , 116 , 117 , 118 , 119 ].…”

Section: Application Of Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

See 2 more Smart Citations

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

et al. 2020

View full text Add to dashboard Cite

In recent years, researchers focused their attention on mesoporous silica nanoparticles (MSNs) owing to the considerable advancements of the characterization methods, especially electron microscopy methods, which allowed for a clear visualization of the pore structure and the materials encapsulated within the pores, along with the X-ray diffraction (small angles) methods and specific surface area determination by Brunauer–Emmett–Teller (BET) technique. Mesoporous silica gained important consideration in biomedical applications thanks to its tunable pore size, high surface area, surface functionalization possibility, chemical stability, and pore nature. Specifically, the nature of the pores allows for the encapsulation and release of anti-cancer drugs into tumor tissues, which makes MSN ideal candidates as drug delivery carriers in cancer treatment. Moreover, the inner and outer surfaces of the MSN provide a platform for further functionalization approaches that could enhance the adsorption of the drug within the silica network and the selective targeting and controlled release to the desired site. Additionally, stimuli-responsive mesoporous silica systems are being used as mediators in cancer therapy, and through the release of the therapeutic agents hosted inside the pores under the action of specific triggering factors, it can selectively deliver them into tumor tissues. Another important application of the mesoporous silica nanomaterials is related to its ability to extract different hazardous species from aqueous media, some of these agents being antibiotics, pesticides, or anti-tumor agents. The purpose of this paper is to analyze the methods of MSN synthesis and related characteristics, the available surface functionalization strategies, and the most important applications of MSN in adsorption as well as release studies. Owing to the increasing antibiotic resistance, the need for developing materials for antibiotic removal from wastewaters is important and mesoporous materials already proved remarkable performances in environmental applications, including removal or even degradation of hazardous agents such as antibiotics and pesticides.

show abstract

Section: Biomedical Applicationsmentioning

confidence: 99%

Section: Cosmeticsmentioning

confidence: 99%

Section: Application Of Mesoporous Silica Nanoparticlesmentioning

confidence: 99%

See 1 more Smart Citation

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

et al. 2020

View full text Add to dashboard Cite

show abstract

“…Cancer is amongst the most pernicious diseases known, due to the high mortality and incidence rates reported [1]. Traditional treatment such as chemotherapy, radiation therapy, and surgery has provided successful treatment and control of cancer to a certain extent [2]. However, each approach comes with its own difficulties, notably being invasive or unspecific in its killing effect leading to grave adverse effects.…”

Section: Introductionmentioning

confidence: 99%

Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics

Nana

Marimuthu

Kondiah

et al. 2019

Cancers

View full text Add to dashboard Cite

Traditional cancer therapeutics are limited by factors such as multi-drug resistance and a plethora of adverse effect. These limitations need to be overcome for the progression of cancer treatment. In order to overcome these limitations, multifunctional nanosystems have recently been introduced into the market. The employment of multifunctional nanosystems provide for the enhancement of treatment efficacy and therapeutic effect as well as a decrease in drug toxicity. However, in addition to these effects, magnetic nanowires bring specific advantages over traditional nanoparticles in multifunctional systems in terms of the formulation and application into a therapeutic system. The most significant of which is its larger surface area, larger net magnetic moment compared to nanoparticles, and interaction under a magnetic field. This results in magnetic nanowires producing a greater drug delivery and therapeutic platform with specific regard to magnetic drug targeting, magnetic hyperthermia, and magnetic actuation. This, in turn, increases the potential of magnetic nanowires for decreasing adverse effects and improving patient therapeutic outcomes. This review focuses on the design, fabrication, and future potential of multifunctional magnetic nanowire systems with the emphasis on improving patient chemotherapeutic outcomes.

show abstract

“…With the fast growing of material chemistry and nanomedicine, biodegradable nanoscale drug delivery platforms, including nanoparticles, micelles ( Wang et al, 2014a ; Li W. et al, 2016 ; Qu et al, 2017 ) and liposomes, have been widely utilized for biomedical diagnosis ( Park et al, 2009 ; Morral-Ruiz et al, 2013 ; Wang et al, 2014b ; Hu et al, 2018 ) and therapy ( Boussif et al, 1995 ; Ding et al, 2013 ; Xing et al, 2013 ; Bertrand et al, 2014 ; You et al, 2016 ; Ge et al, 2017 ; Li et al, 2017 ; Pan et al, 2018 ; Yang et al, 2018 ). Recently, a great number of functional delivery systems ( Liu and Lu, 2006 ; Cho et al, 2011 ; Shrestha et al, 2012 ; Wu et al, 2012 , 2014 ; Li et al, 2013 ; Wu and Chu, 2013 ; Yu et al, 2013 ; Hai et al, 2014 ; Li H. et al, 2016 ; Hao et al, 2017 ; Xu et al, 2017 ) have been studied.…”

Section: Introductionmentioning

confidence: 99%

Human Albumin Fragments Nanoparticles as PTX Carrier for Improved Anti-cancer Efficacy

You

Huang

et al. 2018

Front. Pharmacol.

View full text Add to dashboard Cite

For enhanced anti-cancer performance, human serum albumin fragments (HSAFs) nanoparticles (NPs) were developed as paclitaxel (PTX) carrier in this paper. Human albumins were broken into fragments via degradation and crosslinked by genipin to form HSAF NPs for better biocompatibility, improved PTX drug loading and sustained drug release. Compared with crosslinked human serum albumin NPs, the HSAF-NPs showed relative smaller particle size, higher drug loading, and improved sustained release. Cellular and animal results both indicated that the PTX encapsulated HSAF-NPs have shown good anti-cancer performance. And the anticancer results confirmed that NPs with fast cellular internalization showed better tumor inhibition. These findings will not only provide a safe and robust drug delivery NP platform for cancer therapy, but also offer fundamental information for the optimal design of albumin based NPs.

show abstract

Metal-Based Hybrid Nanoparticles as Radiosensitizers in Cancer Therapy

Cited by 28 publications

References 33 publications

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

Mesoporous Silica Platforms with Potential Applications in Release and Adsorption of Active Agents

Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics

Human Albumin Fragments Nanoparticles as PTX Carrier for Improved Anti-cancer Efficacy

Contact Info

Product

Resources

About