Metal Based Antimicrobials: Uses and Challenges

Salazar-Alemán, Daniel A; Turner, Raymond J.

doi:10.1007/978-3-030-97185-4_4

Cited by 5 publications

(5 citation statements)

References 175 publications

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“…These parameters in part influence the Irving Williams series that reflect the affinity of different ligands for different metal atoms. From all this, we see that metal toxicity roughly follows hard-soft acid-based theory and generally, we see the metal toxicity to bacteria trends to metals that are softer acids (reviewed in Lemire et al 2013 ; Salazar-Alemán and Turner 2022 ).…”

Section: The Goodmentioning

confidence: 65%

“…They just lost their title to organic chemistry and the discovery of antibiotics and antiseptics. Yet, now, due to the high amount of antimicrobial resistance in all pathogens, we see a renaissance in the exploration of metal-based antimicrobials (MBAs) (Turner 2017 ; Salazar-Alemán and Turner 2022 ). In order to get a feeling for the research trends in the field, upon exploring manuscripts in PubMed for the first year of a report on common metals historically used as antimicrobial shows Cu(1943), Ag(1945), Al(1945), Se(1946), Zn(1946), Au(1947), Ni(1950), Ga(1954), Ti(1961).…”

Section: Introductionmentioning

confidence: 99%

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The good, the bad, and the ugly of metals as antimicrobials

Turner

2023

Biometals

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We are now moving into the antimicrobial resistance (AMR) era where more antibiotic resistant bacteria are now the majority, a problem brought on by both misuse and over use of antibiotics. Unfortunately, the antibiotic development pipeline dwindled away over the past decades as they are not very profitable compounds for companies to develop. Regardless researchers over the past decade have made strides to explore alternative options and out of this we see revisiting historical infection control agents such as toxic metals. From this we now see a field of research exploring the efficacy of metal ions and metal complexes as antimicrobials. Such antimicrobials are delivered in a variety of forms from metal salts, alloys, metal complexes, organometallic compounds, and metal based nanomaterials and gives us the broad term metalloantimicrobials. We now see many effective formulations applied for various applications using metals as antimicrobials that are effective against drug resistant strains. The purpose of the document here is to step aside and begin a conversation on the issues of use of such toxic metal compounds against microbes. This critical opinion mini-review in no way aims to be comprehensive. The goal here is to understand the benefits of metalloantimicrobials, but also to consider strongly the disadvantages of using metals, and what are the potential consequences of misuse and overuse. We need to be conscious of the issues, to see the entire system and affect through a OneHealth vision.

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Section: The Goodmentioning

confidence: 65%

Section: Introductionmentioning

confidence: 99%

The good, the bad, and the ugly of metals as antimicrobials

Turner

2023

Biometals

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“…The use of metal-based nanoparticles as components in the creation of antibacterial agents has been made possible by nanotechnologies. Metal-based nanoparticles (NPs) demonstrate an effective role in locating and eliminating bacteria through a variety of mechanisms, including attraction to the surface of the bacteria, disruption of the cell wall and membrane, and induction of a toxic mechanism mediated by an increase in oxidative stress (e.g., the production of reactive oxygen species (ROS)) [35][36][37][38]. The creation of oxidative stress is a valuable and effective antibacterial method to combat MDR bacteria, given the absence of new antimicrobial medicines with unique mechanisms of action.…”

Section: Metal-based Nanoparticles As Antimicrobialsmentioning

confidence: 99%

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

Kaur

Kaur²,

Alyami

et al. 2023

Antibiotics

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The nature of microorganisms and the efficiency of antimicrobials have witnessed a huge co-dependent change in their dynamics over the last few decades. On the other side, metals and metallic compounds have gained popularity owing to their effectiveness against various microbial strains. A structured search of both research and review papers was conducted via different electronic databases, such as PubMed, Bentham, Springer, and Science Direct, among others, for the present review. Along with these, marketed products, patents, and Clinicaltrials.gov were also referred to for our review. Different microbes such as bacteria, fungi, etc., and their diverse species and strains have been reviewed and found to be sensitive to metal-carrying formulations. The products are observed to restrict growth, multiplication, and biofilm formation effectively and adequately. Silver has an apt use in this area of treatment and recovery, and other metals like copper, gold, iron, and gallium have also been observed to generate antimicrobial activity. The present review identified membrane disruption, oxidative stress, and interaction with proteins and enzymes to be the primary microbicidal processes. Elaborating the action, nanoparticles and nanosystems are shown to work in our favor in well excelled and rational ways.

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“…Several metals, such as silver or copper, have demonstrated notable antibacterial effects, opening new avenues for combating microbial infections. [5][6][7][8][9] In addition, combinations of various metals in nanomaterials present numerous advantages compared to nanoparticles consisting of a single metal. These advantages include improved properties, leading to synergistic effects and customized features, multifunctionality, stability, cost-effectiveness, and the potential for novel applications.…”

Section: Introductionmentioning

confidence: 99%

CuAgNPs-enzyme Biohybrids as Antimicrobial nanomaterials

Ortega-Nieto,

Losada-Garcia,

Domingo-Calap

et al. 2024

Preprint

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Multidrug-resistant bacterial infections have become major threats to public health worldwide. Thus, bimetallic Ag-Cu nanoparticles-enzyme biohybrids has been developed. Different bimetallic bionanohybrids were synthesized with different contents of Ag, by the direct incubation of a previous synthesized Cu3(PO4)2NPs-CALB hybrid with silver salt in aqueous media and r.t. They were fully characterized, determining silver phosphate as metal species, and different nanoparticles sizes depending on the amount of silver used. HAADF-STEM analyses demonstrated the formation of individual Ag3PO4 NPs on the Cu-CALB nanoflowers. The catalytic reductase or oxidase-like activities of the bimetallic biohybrids was also affected being higher values when lower amount of silver was used. This effect was corroborated in their antimicrobial efficacy against Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Mycobacterium smegmatis. Results indicate that the presence of small content on silver in the bimetallic hybrids highly enhanced the antibacterial activity compared to initial Cu36@CALB hybrid. Optimal amount of silver has been found corresponding to the bimetallic Ag4Cu32@CALB hybrid which showed the strongest antibacterial effect, with log reductions of 7.6, 4.3 and 3.9 for K. pneumoniae, P. aeruginosa, E. coli, and 1.8 for M. smegmatis. Overall, these novel nanomaterials are a promising alternative for fight against different pathogens.

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Metal Based Antimicrobials: Uses and Challenges

Cited by 5 publications

References 175 publications

The good, the bad, and the ugly of metals as antimicrobials

The good, the bad, and the ugly of metals as antimicrobials

Combating Microbial Infections Using Metal-Based Nanoparticles as Potential Therapeutic Alternatives

CuAgNPs-enzyme Biohybrids as Antimicrobial nanomaterials

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