Metal Allergy: Mercury

Guzzi, Gianpaolo; Pigatto, Paolo D.

doi:10.1007/978-3-319-58503-1_31

Cited by 2 publications

(4 citation statements)

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“…46 Neurological manifestations of acrodynia in children, including tremor, hypotonia, irritability, apathy, insomnia, and seizures, have been documented. [53][54][55] Inorganic mercury in the central nervous system has been shown to increase susceptibility to seizures and prolong these seizures. 56 Mercury has been documented to enter the neuron through calcium and sodium channels and cause permanent depolarization, resulting in neurotransmitter release.…”

Section: On the Central Nervous Systemmentioning

confidence: 99%

“…44,62,63 Mercury has been documented to induce autoimmune diseases such as Kawasaki disease in genetically susceptible individuals. 55 However, the clinical presentation of Kawasaki disease can resemble acrodynia 55, and acrodynia should be considered as a differential.…”

Section: On the Cardiovascular Systemmentioning

confidence: 99%

“…It presents with cutaneous lesions that include pain, alopecia, swelling of the hands, feet, and nose, desquamation, loss of nails, and, in severe cases, gangrene of fingers and toes. [53][54][55]65 Exposure to mercury early on in life may result in numerous adverse systemic effects in children who are typically more sensitive to its harmful effects than adults. Children's organ systems and tissues are rapidly developing, and damage at these stages may culminate in organ dysfunction that can extend into old age and cause morbidity and mortality later in life.…”

Section: On the Immune Systemmentioning

confidence: 99%

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Childhood effects of prenatal and postnatal exposure to mercurial skin lightening agents. Literature Review

et al. 2021

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Children's exposure to mercurial skin lightening agents at any time during their development, from intra-uterine to early developmental life, can lead to severe detrimental health effects. This is because these skin lightening agents contain inorganic mercury as their active ingredient at varying concentrations that exceed acceptable levels. Mercury does not confer any physiological benefit to the human body, and as such, it has only been linked to numerous adverse effects on users and may pose a possible health risk for children born to, living with, and in contact with skin bleaching agent users. Although studies have shown that inorganic mercury exposure may be detrimental to children, there is a paucity of data, to the best of our knowledge, on reviews exploring specifically the possible routes of exposure to and effects of mercurial skin lightening agents on children. Since prevention is the only key to reducing mercury poisoning and toxicity, this study aims to extensively review the literature on prenatal and postnatal exposure to mercury in children from cosmetic skin lightening agents and discuss possible detrimental effects.

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Section: On the Central Nervous Systemmentioning

confidence: 99%

Section: On the Cardiovascular Systemmentioning

confidence: 99%

Section: On the Immune Systemmentioning

confidence: 99%

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Childhood effects of prenatal and postnatal exposure to mercurial skin lightening agents. Literature Review

et al. 2021

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“…Mercury is a well-known neurotoxicant and is able to damage the peripheral nerve myelin. 3 In fact, we would like to draw attention to an additional direct immune effect of the metal (Hg 0 ), which triggers the production of anticardiolipin-antibodies, antineutrophilic cytoplasmatic antibodies (p-ANCA, c-ANCA), C3 complement, gamma globulins, immune-complexes, and antinuclear (ANA)–antinucleolar (ANoA) antibodies, resulting in autoimmune diseases. 3 The case study from Dr Evans and colleagues 1 provides valuable information about a very rare syndrome of mercury-induced immune-mediated polyneuropathy.…”

mentioning

confidence: 99%