Metagenomic studies of the Red Sea

Behzad, Hayedeh; Ibarra, Martin; Mineta, Katsuhiko; Gojobori, Takashi

doi:10.1016/j.gene.2015.10.034

Cited by 39 publications

(40 citation statements)

References 61 publications

(56 reference statements)

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“…Consequently, diverse Red Sea associated microbiomes have been the focus of several recent studies at KAUST, including those from different environments: mangrove sediment (Al-Amoudi et al 2016a; Al-Amoudi et al 2016b; Alzubaidy et al 2016; Simões et al 2015), sea water (Qian et al 2011; Jimenez-Infante et al 2016), coral (Bayer et al 2013), sponge (Gao et al 2015; Tian et al 2014), and extreme niches such as Red Sea brine pools (Mwirichia et al 2016; Zhang et al 2015; Kamanda Ngugi et al 2015; Siam et al 2012; Abdallah et al 2014; Antunes et al 2015; Behzad et al 2016; Jimenez-Infante et al 2014; Grötzinger et al 2014). Such studies focused on relevant microbial bioactivities, such as for example antibacterial activity (Sagar et al, 2013a, b; Moitinho-Silva et al 2014; Abdelmohsen et al 2014).…”

Section: Hypersaline Adapted Bacteria Inhabiting the Red Seamentioning

confidence: 99%

“…Metagenomics studies of Red Sea samples show a distinctive composition of local microbiota, quite distinct from other marine environments (Thompson et al 2013). This is a specific consequence of the 25 Red Sea brine pools, thought to be inhospitable to organic life, harboring bacteria that thrive in these hydrothermal and hypersaline deep-sea environments (Mwirichia et al 2016; Zhang et al 2015; Kamanda Ngugi et al 2015; Grötzinger et al 2014; Siam et al 2012; Abdallah et al 2014; Antunes et al 2015; Behzad et al 2016; Jimenez-Infante et al 2014). An interesting study of vertical stratification was reported for two hydrothermal and hypersaline deep-sea pools in the Red Sea: the Atlantis II and Discovery.…”

Section: Hypersaline Adapted Bacteria Inhabiting the Red Seamentioning

confidence: 99%

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Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity

Nielsen

Archer

Essack

et al. 2017

Appl Microbiol Biotechnol

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The incentive for developing microbial cell factories for production of fuels and chemicals comes from the ability of microbes to deliver these valuable compounds at a reduced cost and with a smaller environmental impact compared to the analogous chemical synthesis. Another crucial advantage of microbes is their great biological diversity, which offers a much larger “catalog” of molecules than the one obtainable by chemical synthesis. Adaptation to different environments is one of the important drives behind microbial diversity. We argue that the Red Sea, which is a rather unique marine niche, represents a remarkable source of biodiversity that can be geared towards economical and sustainable bioproduction processes in the local area and can be competitive in the international bio-based economy. Recent bioprospecting studies, conducted by the King Abdullah University of Science and Technology, have established important leads on the Red Sea biological potential, with newly isolated strains of Bacilli and Cyanobacteria. We argue that these two groups of local organisms are currently most promising in terms of developing cell factories, due to their ability to operate in saline conditions, thus reducing the cost of desalination and sterilization. The ability of Cyanobacteria to perform photosynthesis can be fully exploited in this particular environment with one of the highest levels of irradiation on the planet. We highlight the importance of new experimental and in silico methodologies needed to overcome the hurdles of developing efficient cell factories from the Red Sea isolates.

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Section: Hypersaline Adapted Bacteria Inhabiting the Red Seamentioning

confidence: 99%

Section: Hypersaline Adapted Bacteria Inhabiting the Red Seamentioning

confidence: 99%

Building a bio-based industry in the Middle East through harnessing the potential of the Red Sea biodiversity

Nielsen

Archer

Essack

et al. 2017

Appl Microbiol Biotechnol

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“…Most recent study has developed the metagenomics for advanced characterization of microbial diversity from environmental sample. Behzad et al have also suggested that only a broad and representative metagenmic database could help to identify a dynamic modal of the microbiota that reside in different niches of the Red Sea [9]. In addition, the metagenomic database also revealed the majority of non-cultivable environmental strains and other unknown microbial sp., which were unexplored due to unstable cultivation conditions and other non-advanced techniques.…”

Section: Identification Of Microbial Communitiesmentioning

confidence: 99%

“…The enormous generated data also helped to identify a huge number of microbial genes, their mechanisms of adaptation, interaction within sp. and community, metabolite production and pathways as well as their pharmaceutical and biotechnology-based applications [9]. Therefore, direct metagenomic sequencing analysis of community DNA pools open the door for metatranscriptomics and metaproteomics analysis, and subsequently provided the related information to community physiology.…”

Section: Identification Of Microbial Communitiesmentioning

confidence: 99%

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Red Sea Microbial Diversity for Antimicrobial and Anticancer Agents

M¹

2016

J Mol Biomark Diagn

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Marine natural products are valuable sources that could produce potential chemotherapeutic agents, and marinederived organisms are widely recognized as important sources of these natural products with interesting biological activities. Furthermore, Red sea was recognized as a rich source of microbial diversity with unique metabolites that can be of pharmaceutical and medicinal importance. The discovery of novel active metabolites provides an intellectual challenge to examine new products for medicinal purposes. Although many bacterial strains were isolated from Red sea with potent bioactivities; however, the microbial diversity of marine environment such Red sea remained largely un-explored. Lately, it has been possible to easily collect marine samples, isolate, and further identify diverse marine organisms (e.g. bacteria, fungi, and algae and marine invertebrate) by modern molecular techniques. Based on a wide range of screening and extraction methods, a vast number of metabolites have been extracted from marine sources with potential biological activities such as antibacterial, anticancer, anti-inflammatory agents and many others. In this article, we have reviewed the previous studies that have been conducted to explore marine-derived bioactives of Red sea. In addition, we have illustrated the following aspects: (i) Red sea microbial diversity for antibacterial and anticancer agents; (ii) the conventional and molecular approach used for screening and characterization marine microorganisms; (iii) characterization of natural products of microbial origin, and (iv) drug development from novel marine-derived metabolites and clinical trials. Moreover, modern molecular technologies, meta-genomic, proteomic and bio-chemo-informatics approaches are adding more potency to the targeted search of bioactive compounds derived from marine microbes. The novel marine derived drug discovery is aimed to improve our understanding of natural resources, to improve public health awareness about the environmental microbial diversity and their importance for nutraceuticals, pharmaceutical, agrochemicals and food processing. Recently, the research area of microbial diversity of the Red sea and their metabolites has opened a new access for significant sources of more effective drug entities with low coast.extreme conditions such as high temperature, pressure, and salinity. The experimental results suggested that these bacterial and archaeal communities are rich sources of active enzymes and metabolites, which can be applied for pharmaceutical and biotechnology-based applications [9].In previous studies, a number of bio-active compounds have been reported from marine sources with different degrees of action and potential, such as antibacterial, anticancer, antitumor, antiproliferative, anti-microtubule, cytotoxic, photoprotective, and antifouling properties [10][11][12]. Marine-derived metabolites, like peptides (ribosomal and non-ribosomal), alkaloids, polyketides and terpenes, have demonstrated antimicrobial and antiviral activ...

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