Metagenomic next-generation sequencing as a diagnostic tool in the clinical routine of an infectious diseases department: a retrospective cohort study
Sven Kalbitz,
Jörg Ermisch,
Nils Kellner
et al.
Abstract:Background
Metagenomic next-generation sequencing (mNGS) of circulating cell-free DNA from plasma is a hypothesis-independent broadband diagnostic method for identification of potential pathogens. So far, it has only been investigated in special risk populations (e.g. patients with neutropenic fever).
Purpose
To investigate the extent to which mNGS (DISQVER® platform) can be used in routine clinical practice.
Methods
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