Metagenomic analysis reveals gut bacterial signatures for diagnosis and treatment outcome prediction in bipolar depression

Lai, Jianbo; Li, Ang; Jiang, Jiajun; Yuan, Xiuxia; Zhang, Peifen; Xi, Caixi; Wu, Lingling; Wang, Zheng; Chen, Jingkai; Lu, Joan; Lu, Shengyong; Mou, Tingting; Zhou, Hetong; Wang, Dandan; Huang, Manli; Dong, Fengqin; Li, Ming D.; Xu, Yi; Song, Xueqin; Hu, Shaohua

doi:10.1016/j.psychres.2021.114326

Cited by 15 publications

(11 citation statements)

References 64 publications

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“…MIME has also been successfully used to predict the response of IBD patients to a low FODMAP diet [ 61 ] or anti-TNF treatment [ 62 ], the efficacy of synbiotic treatment of gastrointestinal disease in children [ 63 ], or the prediction of the clinical outcome of bariatric surgery [ 64 ]. The gut microbiota may serve as a biomarker for selecting the most effective drugs for the treatment of rheumatoid arthritis [ 65 ], and gut bacterial signatures have even been described to characterize the diagnosis and predict treatment outcomes in bipolar depression [ 66 ].…”

Section: Discussionmentioning

confidence: 99%

Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial

et al. 2023

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Aim The metabolic performance of the gut microbiota contributes to the onset of type 2 diabetes. However, targeted dietary interventions are limited by the highly variable inter-individual response. We hypothesized (1) that the composition of the complex gut microbiome and metabolome (MIME) differ across metabolic spectra (lean-obese-diabetes); (2) that specific MIME patterns could explain the differential responses to dietary inulin; and (3) that the response can be predicted based on baseline MIME signature and clinical characteristics. Method Forty-nine patients with newly diagnosed pre/diabetes (DM), 66 metabolically healthy overweight/obese (OB), and 32 healthy lean (LH) volunteers were compared in a cross-sectional case-control study integrating clinical variables, dietary intake, gut microbiome, and fecal/serum metabolomes (16 S rRNA sequencing, metabolomics profiling). Subsequently, 27 DM were recruited for a predictive study: 3 months of dietary inulin (10 g/day) intervention. Results MIME composition was different between groups. While the DM and LH groups represented opposite poles of the abundance spectrum, OB was closer to DM. Inulin supplementation was associated with an overall improvement in glycemic indices, though the response was very variable, with a shift in microbiome composition toward a more favorable profile and increased serum butyric and propionic acid concentrations. The improved glycemic outcomes of inulin treatment were dependent on better baseline glycemic status and variables related to the gut microbiota, including the abundance of certain bacterial taxa (i.e., Blautia, Eubacterium halii group, Lachnoclostridium, Ruminiclostridium, Dialister, or Phascolarctobacterium), serum concentrations of branched-chain amino acid derivatives and asparagine, and fecal concentrations of indole and several other volatile organic compounds. Conclusion We demonstrated that obesity is a stronger determinant of different MIME patterns than impaired glucose metabolism. The large inter-individual variability in the metabolic effects of dietary inulin was explained by differences in baseline glycemic status and MIME signatures. These could be further validated to personalize nutritional interventions in patients with newly diagnosed diabetes.

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Section: Discussionmentioning

confidence: 99%

Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial

et al. 2023

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“… Xie et al (2020) carried out 2-week electroacupuncture intervention in mice, and found that electroacupuncture could inhibit proinflammatory shift with promoting the recovery of the relative abundance of Akkermansia , Clostridium , Lactococcus, and Butyricimonas in the intestinal tract, and significantly increase the relative abundance of Lactobacillus . A number of bacteria above are capable of inhibiting inflammation, protecting the intestinal barrier and preventing depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ). All of the above bacteria have the potential to inhibit inflammation, protect the intestinal barrier, and prevent depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ).…”

Section: Acupuncture Regulates Intestinal Microbiota In Psdmentioning

confidence: 99%

“…A number of bacteria above are capable of inhibiting inflammation, protecting the intestinal barrier and preventing depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ). All of the above bacteria have the potential to inhibit inflammation, protect the intestinal barrier, and prevent depression ( Guo et al, 2022 ; Lai et al, 2022 ; Ramalho et al, 2022 ). It can be seen that acupuncture alleviates systemic inflammation in rats overall through the increase in beneficial microorganisms’ abundance.…”

Section: Acupuncture Regulates Intestinal Microbiota In Psdmentioning

confidence: 99%

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Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

et al. 2023

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Stroke-induced depression is a common complication and an important risk factor for disability. Besides psychiatric symptoms, depressed patients may also exhibit a variety of gastrointestinal symptoms, and even take gastrointestinal symptoms as the primary reason for medical treatment. It is well documented that stress may disrupt the balance of the gut microbiome in patients suffering from post-stroke depression (PSD), and that disruption of the gut microbiome is closely related to the severity of the condition in depressed patients. Therefore, maintaining the balance of intestinal microbiota can be the focus of research on the mechanism of acupuncture in the treatment of PSD. Furthermore, stroke can be effectively treated with acupuncture at all stages and it may act as a special microecological regulator by regulating intestinal microbiota as well. In this article, we reviewed the studies on changing intestinal microbiota after acupuncture treatment and examined the existing problems and development prospects of acupuncture, microbiome, and poststroke depression, in order to provide new ideas for future acupuncture research.

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“…Lai et al [ 79 ] reported that depressed patients with bipolar disorder following quetiapine monotherapy have specific alterations in gut microbial diversity and composition. The abundance of Clostridium bartlettii was negatively associated with age and baseline depression severity, while positively associated with spontaneous neural oscillation in the hippocampus.…”

Section: Dysbiosis and Depressionmentioning

confidence: 99%

Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota

et al. 2022

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Major depressive disorder (MDD) is a common mental illness. Evidence suggests that the gut microbiota play an essential role in regulating brain functions and the pathogenesis of neuropsychiatric diseases, including MDD. There are numerous mechanisms through which the gut microbiota and brain can exchange information in a continuous, bidirectional communication. Current research emphasizes the interexchange of signals influenced by the gut microbiota that are detected and transduced in information from the gut to the nervous system involving neural, endocrine, and inflammatory mechanisms, suggesting a relationship between oxidative stress and the pathophysiology of MDD via the hyperactivation of inflammatory responses. Potential sources of inflammation in the plasma and hippocampus of depressed individuals could stem from increases in intestinal permeability. Some nutraceuticals, such as specific probiotics, namely psychobiotics, polyphenols, carotenoids, butyrate, and prebiotics, have been demonstrated to exert an antidepressant activity, but most of them need to be metabolized and activated by gut microorganisms. By inducing changes in the gut microbiota composition, physical exercise might also exert a role in alleviating depression-like symptoms. The mutual relationships among nutraceuticals, exercise, and depression will be discussed, and the potential role of the gut microbiota as a therapeutic target to treat depression will be explored.

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Metagenomic analysis reveals gut bacterial signatures for diagnosis and treatment outcome prediction in bipolar depression

Cited by 15 publications

References 64 publications

Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial

Multi-omics signatures in new-onset diabetes predict metabolic response to dietary inulin: findings from an observational study followed by an interventional trial

Acupuncture treatment for post-stroke depression: Intestinal microbiota and its role

Nutraceuticals and Physical Activity as Antidepressants: The Central Role of the Gut Microbiota

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