Metacognition of emotion recognition across neurodegenerative diseases

García‐Cordero, Indira; Migeot, Joaquín; Fittipaldi, Sol; Aquino, Alexia; Campo, Cecilia González; García, Adolfo M.; Ibáñez, Agustín

doi:10.1016/j.cortex.2020.12.023

Cited by 27 publications

(32 citation statements)

References 101 publications

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“…From a clinical perspective, a novel agenda is opened, related to basic and clinical innovations at the crossing of cognitive neuroscience and behavioral neurology. Present findings offer new insights about interventions related to body awareness ( Fustos et al, 2013 ; Müller et al, 2015 ) and metacognition of emotion ( García-Cordero et al, 2021 ), interoceptive priors, and allostatic predictive coding addressing patients' emotional-self regulation.…”

Section: Discussionmentioning

confidence: 85%

Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration

et al. 2021

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Recent frameworks in cognitive neuroscience and behavioral neurology underscore interoceptive priors as core modulators of negative emotions. However, the field lacks experimental designs manipulating the priming of emotions via interoception and exploring their multimodal signatures in neurodegenerative models. Here, we designed a novel task that involves interoceptive and control-exteroceptive priming conditions followed by post-Intero and post-Extero facial emotion recognition (FER). We recruited 114 participants, including healthy controls (HCs) as well as patients with behavioral variant frontotemporal dementia (bvFTD), Parkinson's disease (PD), and Alzheimer's disease (AD). We measured online EEG modulations of the heart-evoked potential (HEP), and associations with both brain structural and resting-state functional connectivity patterns. Behaviorally, post-Intero negative FER was enhanced in HCs but selectively disrupted in bvFTD and PD, with AD presenting generalized disruptions across emotion types. Only BvFTD presented impaired interoceptive accuracy. Increased HEP modulations during post-Intero negative FER was observed in HCs and AD, but not in bvFTD or PD patients. Across all groups, post-Intero negative FER correlated with the volume of the insula and the anterior cingulate cortex. Also, negative FER was associated with functional connectivity along the (a) salience network in the post-Intero condition, and along the (b) executive network in the post-Extero condition. These patterns were selectively disrupted in bvFTD (a) and PD (b), respectively.Our approach underscores the multidimensional impact of interoception on emotion, while revealing a specific pathophysiological marker of bvFTD. These findings inform a promising theoretical and clinical agenda in the fields of interoception, emotion, allostasis, and neurodegeneration.

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Section: Discussionmentioning

confidence: 85%

Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration

et al. 2021

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“…Such interoceptive dysregulations, however, are also present in other neurodegenerative conditions [123]. Although not without conflicting results, individuals with Alzheimer's disease tend to present impaired performance in interoceptive tasks [28] along with abnormal modulations of the HEP, in addition to deficits in interoceptive awareness and learning [124]. Moreover, cardiac interoception deficits are also present in Parkinson's disease [125,126], which may help distinguish among postural instability/gait difficulty and tremor dominant variants [127].…”

Section: Allostasis and Allostatic Overloadmentioning

confidence: 99%

A predictive coding framework of allostatic–interoceptive overload in frontotemporal dementia

Migeot¹,

Duran‐Aniotz²,

Signorelli³

et al. 2022

Trends in Neurosciences

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“…Patients' clinical diagnoses were established by a multidisciplinary team following formal criteria, as done in previous multicentric studies [19][20][21][22][23][24][25]. To align local sites' procedures, each center used the Multi-Partner Consortium to Expand Dementia Research in Latin America (ReDLat) standardized diagnostic assessment [19,20].…”

Section: Participantsmentioning

confidence: 99%

“…All participants performed the MiniSEA (version published in the native language of the corresponding country [20,25,34,35]), which comprises two subtests: a FER test and a shortened version of the Faux Pas test, tapping ToM. The total MiniSEA score is the sum of both subscores, yielding a maximum score of 30.…”

Section: Miniseamentioning

confidence: 99%

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Predicting and Characterizing Neurodegenerative Subtypes with Multimodal Neurocognitive Signatures of Social and Cognitive Processes

Ibáñez

Fittipaldi

Trujillo

et al. 2021

JAD

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Background: Social cognition is critically compromised across neurodegenerative diseases, including the behavioral variant frontotemporal dementia (bvFTD), Alzheimer’s disease (AD), and Parkinson’s disease (PD). However, no previous study has used social cognition and other cognitive tasks to predict diagnoses of these conditions, let alone reporting the brain correlates of prediction outcomes. Objective: We performed a diagnostic classification analysis using social cognition, cognitive screening (CS), and executive function (EF) measures, and explored which anatomical and functional networks were associated with main predictors. Methods: Multiple group discriminant function analyses (MDAs) and ROC analyses of social cognition (facial emotional recognition, theory of mind), CS, and EF were implemented in 223 participants (bvFTD, AD, PD, controls). Gray matter volume and functional connectivity correlates of top discriminant scores were investigated. Results: Although all patient groups revealed deficits in social cognition, CS, and EF, our classification approach provided robust discriminatory characterizations. Regarding controls, probabilistic social cognition outcomes provided the best characterization for bvFTD (together with CS) and PD, but not AD (for which CS alone was the best predictor). Within patient groups, the best MDA probabilities scores yielded high classification rates for bvFTD versus PD (98.3% , social cognition), AD versus PD (98.6% , social cognition + CS), and bvFTD versus AD (71.7% , social cognition + CS). Top MDA scores were associated with specific patterns of atrophy and functional networks across neurodegenerative conditions. Conclusion: Standardized validated measures of social cognition, in combination with cognitive screening, can provide a dimensional classification with specific pathophysiological markers of neurodegeneration diagnoses.

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Metacognition of emotion recognition across neurodegenerative diseases

Cited by 27 publications

References 101 publications

Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration

Interoception Primes Emotional Processing: Multimodal Evidence from Neurodegeneration

A predictive coding framework of allostatic–interoceptive overload in frontotemporal dementia

Predicting and Characterizing Neurodegenerative Subtypes with Multimodal Neurocognitive Signatures of Social and Cognitive Processes

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