Metachronous squamous cell carcinoma of the esophagus arising after endoscopic mucosal resection☆, ☆☆

Shimizu, Yuzuru; Tukagoshi, Hiroyuki; Fujita, Mayu; Hosokawa, Masahi; Kato, M.; Asaka, M

doi:10.1016/s0016-5107(01)70105-8

Cited by 32 publications

(54 citation statements)

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“…It was considered that the local recurrence rate in the present study was lower than those in previous studies because the patients were mainly treated by EMR in the previous studies. In previous studies, it was reported that multiple squamous epithelial dysplasia in the esophageal mucosa can be visualized by chromoendoscopy with Lugol ' s solution as multiple LVLs ( 29,30 ), and that metachronous SCC of the esophagus frequently develops in patients with scattered iodine staining of the background mucosa ( 39 ). Similarly, in this study, multiple LVLs were risk factors that achieved statistical signifi cance for recurrence.…”

Section: Esophagussupporting

confidence: 69%

Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan

Nakagawa

Koike

Iijima

et al. 2014

American Journal of Gastroenterology

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OBJECTIVES:Few studies have simultaneously evaluated the long-term outcomes of endoscopic resection (ER) for squamous cell carcinoma (SCC) and adenocarcinoma (AC) of the esophagus in Japan. The objective of this study was to evaluate the long-term outcomes of ER for superfi cial esophageal cancer in consecutive patients. METHODS:This was a retrospective study from a single institution. From April 2001 to June 2012, 204 patients with SCC and 26 patients with AC were included from a total of 355 consecutive patients who were treated by esophageal ER at the Tohoku University Hospital. Patients with submucosal invasion deeper than 200 μ m and lymphovascular involvement were excluded. The intervention followed was endoscopic therapy. RESULTS:Overall survival, disease-free survival, and recurrence rates were evaluated as long-term outcomes. In the SCC group, during the median observation time of 36.5 months (range, 6 -120 months), 22 (10.8 % ) patients experienced metachronous recurrence, 4 (2.0 % ) patients experienced local recurrence, and 27 (13.2 % ) patients died from causes unrelated to SCC. In the AC group, during the median observation time of 45.5 months (range, 6 -131 months), one patient (3.8 % ) experienced metachronous recurrence and two (7.7 % ) died from causes unrelated to AC. The cumulative 5-year overall survival rates were not signifi cantly different between SCC (75.9 % ) and AC (88.9 % ) ( P = 0.120). The cumulative 5-year disease-free survival rates of SCC (57.1 % ) were signifi cantly lower than those of AC (85.2 % ; P = 0.017). The cumulative 5-year recurrence rates of SCC (32.0 % ) were signifi cantly higher than those of AC (4.2 % ; P = 0.023). CONCLUSIONS:The rate of recurrence after ER was higher in patients with SCC than that in patients with AC. These fi ndings suggest that, by detecting AC of the esophagus earlier, a satisfactory prognosis without recurrence can be expected after ER in Japan, and more rigorous endoscopic follow-up is necessary after ER in patients with SCC than in those with AC.

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Section: Esophagussupporting

confidence: 69%

Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan

Nakagawa

Koike

Iijima

et al. 2014

American Journal of Gastroenterology

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“…25 Metachronous neoplasia of the esophagus has been reported to occur in as many as 10-15% of cases after endoscopic therapy and can develop any time after treatment. [25][26][27] Kato et al also found that the incidence of gastric metachronous cancer increased linearly after curative endoscopic resection for early gastric cancer. 24 In our study, the incidence of metachronous lesions showing HGID was only 1.3% at 2 years in each group.…”

Section: Elderly Patients N=130mentioning

confidence: 96%

Efficacy and safety of endoscopic submucosal dissection for elderly patients with superficial squamous esophageal neoplasms

Peng

Shen

et al. 2016

UEG Journal

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Background: Little is known about the outcomes of endoscopic submucosal dissection in elderly patients with superficial squamous esophageal neoplasms. Objective: To assess the efficacy and safety of endoscopic submucosal dissection for superficial squamous esophageal neoplasms in elderly patients (!65 years) compared with non-elderly patients. Methods: All patients with superficial squamous esophageal neoplasms receiving endoscopic submucosal dissection were retrospectively analyzed. Among them, 130 were aged 65 or older (group A), and 201 were aged younger than 65 years (group B). Therapeutic efficacy, adverse events, and follow-up data were evaluated. Results: Group A had a higher prevalence of concomitant diseases than group B (52.3% vs. 14.9%, respectively). R0 resection rate was 82.3% in group A and 84.6 % in group B (P ¼ 0.717). The curative resection rate was 80.8% in group A and 83.6% in group B (P ¼ 0.653). The rate of procedure-related non-cardiopulmonary adverse events was 20.8% in group A and 16.9% in group B (P ¼ 0.377). The incidence of cardiopulmonary adverse events during or after the procedure was 6.2% in group A and 2.5% in group B (P ¼ 0.094). No procedure-related mortality was reported in either group. Conclusion: Endoscopic submucosal dissection is effective and safe for treating superficial squamous esophageal neoplasms in elderly patients.

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“…6 5 The presence of multiple esophageal iodine-unstained lesions and the presence of large esophageal DIULs ≥ 5 mm were correlated with inactive heterozygous ALDH2 5 8, 6 6-6 8 and with increased risk of multiple SCCs in the UADT. 5,58,66,67,69,70 The 6 year cumulative rates of detection of metachronous SCC in the esophagus and oropharyngolarynx were 56% and 35%, respectively, in Japanese alcoholics after endoscopic mucosectomy of esophageal SCC, as opposed to 31% and 20%, respectively, in those with esophageal dysplasia ≥ 5 mm, and 4% and 4%, respectively, in those without DIULs ≥ 5 mm. 7 1 Esophageal dysplasia ≥ 5 mm is associated with a very high risk of SCC in the UADT.…”

Section: Esophageal Dysplasiamentioning

confidence: 99%

Alcohol and Aldehyde Dehydrogenase Polymorphisms and a New Strategy for Prevention and Screening for Cancer in the Upper Aerodigestive Tract in East Asians

2010

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Metachronous squamous cell carcinoma of the esophagus arising after endoscopic mucosal resection☆, ☆☆

Cited by 32 publications

References 0 publications

Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan

Comparison of the Long-Term Outcomes of Endoscopic Resection for Superficial Squamous Cell Carcinoma and Adenocarcinoma of the Esophagus in Japan

Efficacy and safety of endoscopic submucosal dissection for elderly patients with superficial squamous esophageal neoplasms

Alcohol and Aldehyde Dehydrogenase Polymorphisms and a New Strategy for Prevention and Screening for Cancer in the Upper Aerodigestive Tract in East Asians

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