Metachronous isolated locally advanced pancreatic metastasis from chromophobe renal cell carcinoma

Ayari, Y.; Rhouma, Sami Ben; Boussaffa, Hamza; Chelly, Beya; Hamza, K; Sellami, Ahmed; Jrad, M.; Nouira, Yassine

doi:10.1016/j.ijscr.2019.05.046

Cited by 8 publications

(5 citation statements)

References 11 publications

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“…From 421 cases reported casuistically, a cumulative 5-and 10-year survival rate (SR) of 75.7% and 48.4%, respectively, can be calculated (Figure 2). In single and multicentre institutional reports of isolated PM [99,143,183,185,191,201,209,216,234], comparable results were reported with five-year SR of 52%-84%, 53% [99], 61% [143], 52% [183], 72% [184], 56% [190], 71% [200], 69% [208], 80% [215], 84% (Median 72%) [233]. 10a: 63% (median 69%) [254].…”

Section: Surgical Therapysupporting

confidence: 60%

“…In Figure 2, we also present the results of the few observations that were not administered surgically or targeted therapy (TKI, m-tor inhibitors or immunotherapy). The three-year SR of 56% calculated from 19 casuistically reported observations [10,22,63,64,78,90,107,166,175,185,188,194,216,250] is a favourable result for the spontaneous course of a metastatic RCC. However, the result is significantly worse than after interventions with curative intent (p = 0.013).…”

Section: Spontaneous Course Of Ispmrccmentioning

confidence: 99%

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Isolated Pancreatic Metastases of Renal Cell Carcinoma—Clinical Particularities and Seed and Soil Hypothesis

Sellner

Thalhammer

Klimpfinger

2023

Cancers

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A meta-analysis of 1470 isolated pancreatic metastases of renal cell carcinoma revealed, that, in addition to the unusual exclusive occurrence of pancreatic metastases and the favourable treatment results, the isPMRCC is characterised by further peculiarities of the clinical course: The lack of prognostic significance of volume and growth rate dependent risk factors and the independence of treatment results from standard or local resections. As an explanation for all these peculiarities, according to today’s knowledge, a strong acting seed and soil mechanism can serve, which allows embolized tumour cells to grow to metastases only in the pancreas, and prevents them definitively or for years in all other organs. The good prognosis affects not only isolated PM, but also multi-organ metastases of the RCC, in which the additional occurrence of PM is also associated with a better prognosis. Genetic studies revealed specific changes in cases of PM of RCC: Lack of loss of 9p21.3 and 14q31.2, which are otherwise specific gene mutations at the onset of generalization, a low weight genome instability index, i.e., high genetic stability, and a low rate of PAB1 and a high rate of BPRM1 alterations, which signal a more favourable course. The cause of pancreatic organotropism in isPMRCC is still unclear, so only those factors that have been identified as promoting organotropism in other, more frequent tumour entities can be presented: Formation of the pre-metastatic niche, chemokine receptor–ligand mechanism, ability to metabolic adaptation, and immune surveillance.

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Section: Surgical Therapysupporting

confidence: 60%

Section: Spontaneous Course Of Ispmrccmentioning

confidence: 99%

Isolated Pancreatic Metastases of Renal Cell Carcinoma—Clinical Particularities and Seed and Soil Hypothesis

Sellner

Thalhammer

Klimpfinger

2023

Cancers

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“…The site and frequency of metastatic involvement depends on the histologic subtype of RCC—clear cell (ccRCC), papillary (pRCC), spindle cell type (sRCC) and chromophobe (chrRCC). PM are most frequently seen in ccRCC [ 31 , 32 , 33 ]. PM from RCC have also been reported in ectopic pancreatic tissue, such as in the case reported by Yano et al [ 34 ].…”

Section: Discussionmentioning

confidence: 99%

Metastatic Renal Cell Carcinoma to Pancreas: Case Series and Review of the Literature

et al. 2023

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Metastasis to the pancreas represents a small proportion of all pancreatic malignancies. Among primary tumors that metastasize to the pancreas, renal cell carcinoma (RCC) is one of the most common causes of metastatic pancreatic lesions. We herein report a case series of three patients with pancreatic metastasis from RCC. The first is a 54-year-old male with a history of left nephrectomy for RCC, in whom an isthmic pancreatic mass suggestive of a neuroendocrine lesion was found during oncological follow-up. Endoscopic ultrasound (EUS)-guided fine needle biopsy (FNB) identified pancreatic metastasis of RCC and the patient was referred for surgery. The second case is a 61-year-old male, hypertensive, diabetic, with left nephrectomy for RCC six years previously, who complained of weight loss and was found with a hyperenhancing mass in the head of the pancreas and a lesion with a similar pattern in the gallbladder. EUS-FNB from the pancreas proved to be a metastatic pancreatic lesion. Cholecystectomy and treatment with tyrosine kinase inhibitors were recommended. The third case is a 68-year-old dialysis patient referred for evaluation of a pancreatic mass, also confirmed by EUS-FNB, who was started on sunitinib treatment. We report a literature summary on epidemiology and clinical features, diagnosis and differential diagnosis and treatment and outcomes in pancreatic metastasis of RCC.

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“…ChRCC develops from dark cells in the collecting duct epithelium of the kidney [ 15 ]. There was 89.3% recurrence-free survival (RFS) and 93% cancer-specific survival (CSS) rates for chRCC after 5 years [ 16 ]. Metastatic disease accounts for only 6% of chRCC patients [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

The Critical Gene Screening to Prevent Chromophobe Cell Renal Carcinoma Metastasis through TCGA and WGCNA

Yan

Yang

Tang

et al. 2022

Journal of Oncology

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Common chromophobe renal cell carcinoma (chRCC) has a good prognosis when cured by surgery. However, clinical practice shows that a small number of patients with chRCC will produce metastasis, and the prognosis after metastasis is poor. In this regard, we try to find potential biological targets to prevent CRCC metastasis. In this experiment, we analyzed the clinical traits and gene expression data of chRCC samples which were provided by the TCGA database by the WGCNA method. On this basis, we selected MEtan, a module with a significant positive correlation with the M phase of chRCC, for subsequent analysis. The MEtan module genes in the biological process of chRCC were mainly related to steroid metabolic process, cholesterol metabolic process and STEM cell differentiation. KEGG analysis showed that these genes were mainly enriched in cancer-related signaling pathways, such as Neuroactive Ligand−receptor interaction, cAMP signaling pathway, and Wnt signaling pathway. Subsequently, we mapped the PPI interaction network and screened the key gene beta-arrestin 2 (ARRB2). Expression analysis showed that there was a significantly increased expression of ARRB2 in chRCC patients in comparison to the normal group. Expression survival analysis indicated that ARRB2 was inversely associated with overall survival. We firmly believe that the key genes identified in this study would be able to provide new clues and research basis for the treatment of chRCC.

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Metachronous isolated locally advanced pancreatic metastasis from chromophobe renal cell carcinoma

Cited by 8 publications

References 11 publications

Isolated Pancreatic Metastases of Renal Cell Carcinoma—Clinical Particularities and Seed and Soil Hypothesis

Isolated Pancreatic Metastases of Renal Cell Carcinoma—Clinical Particularities and Seed and Soil Hypothesis

Metastatic Renal Cell Carcinoma to Pancreas: Case Series and Review of the Literature

The Critical Gene Screening to Prevent Chromophobe Cell Renal Carcinoma Metastasis through TCGA and WGCNA

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