Metabonomics study of atherosclerosis rats by ultra fast liquid chromatography coupled with ion trap-time of flight mass spectrometry

Therapeutic effect of Yunnan Baiyao on rheumatoid arthritis was partially due to regulating arachidonic acid metabolism in osteoblasts

“…4A). Findings from serum metabonomics partially ascertained the previous report that FFAs would increase in RA individuals [20,21]. A report indicated that fasting-associated increases in total plasma FFAs promoted lymphocyte proliferation in vitro and might not facilitate to alleviate inflammation [22].…”

Lysophosphatidylcholine profiling of plasma: discrimination of isomers and discovery of lung cancer biomarkers

“…Hence, in metabonomics studies of liver and kidney diseases, such as chronic hepatitis B (Yang et al 2006) and diabetes mellitus (Zhang et al 2009a), lysoPCs have been used as markers. Recently, Shindou et al (Nakanishi et al 2006;Shindou et al 2009) found that lysoPC can be converted to PC by lysoPC acyltransferases (LPCATs) in the pulmonary surfactant, where they decrease lung surface tension, performing an essential function for respiration.…”

Nutritional Metabolomics

“…Both, 1 H-NMR as well as MS-based methods currently cover only the metabolome ''tip of the iceberg.'' It may therefore not be surprising that identical ''biomarkers'' with similar changes appear in such different diseases as type 2 diabetes, atherosclerosis, and cardiovascular diseases or even depression [39][40][41][42]. This finding questions the specificity and selectivity of current metabolomics approaches when analyzing only at the ''tip of the iceberg.''…”