Metabonomic study on chronic unpredictable mild stress and intervention effects of Xiaoyaosan in rats using gas chromatography coupled with mass spectrometry

Metabonomic identification of the effects of the Zhimu-Baihe saponins on a chronic unpredictable mild stress-induced rat model of depression

“…5-HT is the product of tryptophan metabolism by tryptophan hydroxylase, and it plays 24 some roles in the development of depression as a monoamine neurotransmitters [20].…”

Plasma-metabolite-biomarkers for the therapeutic response in depressed patients by the traditional Chinese medicine formula Xiaoyaosan: A 1H NMR-based metabolomics approach

“…and Rhizoma Zingiberis Recens (Zingiber officinale Rosc.). Prior reports have suggested that Xiaoyaosan shows certain anti-depressive activity (Dai et al, 2010;Gao et al, 2011;Tian et al, 2014). At present, the efficacy evaluation of Xiaoyaosan relies on the presentation of symptoms and rating scale scores, which may lead to a limited sensitivity.…”

DanHong injection dose-dependently varies amino acid metabolites and metabolic pathways in the treatment of rats with cerebral ischemia

“…The main bioactive constituents of DHI are salvianic acid A and B, protocatechuic aldehyde and rosmarinic acid ( Figure S1). Previous studies have shown that DHI exhibited diverse pharmacological effects, including protection against vascular endothelium injury [2,3] , improvements in atherosclerosis and microcirculation [4] , and neuroprotective effects [5] . It has also been suggested that DHI might have a dose-dependent protective effect on promoting angiogenesis and mesenteric microcirculation in acute hypoxia [6,7] .…”