Metabonomic analysis of the hepatic injury suffer from hexavalent chromium poisoning in broilers

Zhao, Yali; Zhang, Hui; Wu, Xiaoxing; Zhang, Tianguang; Shen, Ke; Lei, Li; Peng, Yuxuan; Mehmood, Khalid; Zhou, Daixing

doi:10.1007/s11356-019-05075-4

Cited by 30 publications

(16 citation statements)

References 27 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…According to Hamilton and Wetterhahn (1986) , Cr(VI) caused DNA damage in the liver and blood cells of chick embryos. It was also demonstrated that excessive exposure to Cr(VI) can lead to pathophysiological and histopathological changes in the liver of chicks ( Wang et al., 2017 , 2020 ; Zhao et al., 2019 ). The median lethal dose (LD 50 ) of hexavalent chromium was estimated as 50 to 150 mg/kg in mammals ( Katz and Salem, 1993 ) and 164 mg per kg body weight in broilers ( Zhao et al., 2019 ).…”

Section: Introductionmentioning

confidence: 99%

“…It was also demonstrated that excessive exposure to Cr(VI) can lead to pathophysiological and histopathological changes in the liver of chicks ( Wang et al., 2017 , 2020 ; Zhao et al., 2019 ). The median lethal dose (LD 50 ) of hexavalent chromium was estimated as 50 to 150 mg/kg in mammals ( Katz and Salem, 1993 ) and 164 mg per kg body weight in broilers ( Zhao et al., 2019 ). However, doses of chromium which do not result in any measurable impact on adult animals may seriously affect embryos ( Hui, 2002 ).…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effects of embryonic exposure to chromium (VI) on blood parameters and liver microstructure of 1-day-old chickens

et al. 2021

View full text Add to dashboard Cite

Hexavalent chromium ( Cr(VI) ) has carcinogenic, nephrotoxic, hepatotoxic, and neurotoxic effects. Exposure to Cr(VI) can also lead to hematological alterations and blood biochemical changes. The literature on Cr(VI) toxicity concerns mostly adult forms of vertebrates. In this study, an attempt was made to determine the effect on the developing chicken embryo of Cr(VI) in ovo administration. It was observed that chromium affected the hatchability of chicks in a dose-dependent manner. At a dose from 25 to 250 μg per egg, Cr(VI) resulted in a statistically significant reduction of hatchability. Chromium administrated at lower doses (1.56 and 2.5 μg per egg) caused a statistically insignificant increase of hatchability. However, chromium at a level of LD 50 (15.6 μg per egg) or 1/10 LD 50 (1.56 per egg) did not cause major changes in hematological parameters or plasma biochemical indices in newly hatched chicks. The same doses did not lead to any histopathological changes in the liver.

show abstract

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Effects of embryonic exposure to chromium (VI) on blood parameters and liver microstructure of 1-day-old chickens

et al. 2021

View full text Add to dashboard Cite

show abstract

“…The effect of pH (3,4,5,6,7,8,9, and 10) on the growth of the isolated strains was measured in a 100-well bacterial culture plate. The pH was adjusted by adding either 0.1 M HCl or 0.1 M NaOH as needed, which were tested in triplicate.…”

Section: Conditions For Bacterial Growthmentioning

confidence: 99%

“…These untreated chromium-containing pollutants are mostly released into the environment, posing threats to ecosystems [2,5]. There are two common and stable oxidation states of chromium in the environment, namely Cr(VI) and Cr(III) [8][9][10]. Cr(III) is involved in sugar and lipid metabolism and is less toxic to humans [8,11,12], while Cr(VI) is carcinogenic, teratogenic, and mutagenic and is easily absorbed by humans through biomagnification in the food chain [13,14].…”

Section: Introductionmentioning

confidence: 99%

“…There are two common and stable oxidation states of chromium in the environment, namely Cr(VI) and Cr(III) [8][9][10]. Cr(III) is involved in sugar and lipid metabolism and is less toxic to humans [8,11,12], while Cr(VI) is carcinogenic, teratogenic, and mutagenic and is easily absorbed by humans through biomagnification in the food chain [13,14]. The permissible limit concentration for Cr(VI) in drinking water is less than 50 µg/L, as recommended by the World Health Organization (WHO) and United States Environmental Protection Agency (USEPA) [15][16][17].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Isolation and Identification of Chromium Reducing Bacillus Cereus Species from Chromium-Contaminated Soil for the Biological Detoxification of Chromium

Gao

et al. 2020

IJERPH

View full text Add to dashboard Cite

Chromium contamination has been an increasing threat to the environment and to human health. Cr(VI) and Cr(III) are the most common states of chromium. However, compared with Cr(III), Cr(VI) is more toxic and more easily absorbed, therefore, it is more harmful to human beings. Thus, the conversion of toxic Cr(VI) into Cr(III) is an accepted strategy for chromium detoxification. Here, we isolated two Bacillus cereus strains with a high chromium tolerance and reduction ability, named B. cereus D and 332, respectively. Both strains demonstrated a strong pH and temperature adaptability and survival under 8 mM Cr(VI). B. cereus D achieved 87.8% Cr(VI) removal in 24 h with an initial 2 mM Cr(VI). Cu(II) was found to increase the removal rate of Cr(VI) significantly. With the addition of 0.4 mM Cu(II), 99.9% of Cr(VI) in the culture was removed by B. cereus 332 in 24 h. This is the highest removal efficiency in the literature that we have seen to date. The immobilization experiments found that sodium alginate with diatomite was the better method for immobilization and B. cereus 332 was more efficient in immobilized cells. Our research provided valuable information and new, highly effective strains for the bioremediation of chromium pollution.

show abstract

Hepatic lipid metabolomics in response to heat stress in local broiler chickens breed (Huaixiang chickens)

Guo

Liao

Liang

et al. 2021

Veterinary Medicine & Sci

View full text Add to dashboard Cite

High‐temperature environment‐induced heat stress (HS) is a hazard environmental element for animals, leading to dramatic changes in physiological and metabolic function. However, the metabolomic‐level mechanisms underlying lipid metabolism in liver of slow‐growing broilers are still obscure. The present study investigated the effects of HS on hepatic lipidomics in Chinese indigenous slow‐growing broilers (Huaixiang chickens). The study includes two treatments, each treatment had 5 replicates with 4 broilers per cage, where a total of 40 eight‐week‐old female Huaixiang chickens (average initial body weight of 840.75 ± 20.79 g) were randomly divided into normal temperature (NT) and HS groups for 4 weeks, and the broilers of NT and HS groups were exposed to 21.3 ± 1.2℃ and 32.5 ± 1.4℃ respectively. The relative humidity of the two groups was maintained at 55%–70%. The liquid chromatography‐mass spectrometry (LC‐MS)‐based metabolomics were conducted to evaluate the changes in hepatic lipidomics of broilers. The results showed that there were 12 differential metabolites between the two treatments. Compared with the NT group, HS group reduced the levers of hepatic phosphatidylcholine (PC) (16:0/16:0), PC (16:0/18:2), triglyceride (TG) (16:0/16:1/18:1), TG (18:0/18:1/20:4) (VIP > 1 and p < 0.05), while increased PC (18:1/20:3), PC (18:0/18:1), PC (18:1/18:1), PC (18:0/22:5), dimethyl‐phosphatidyl ethanolamine (dMePE) (14:0/18:3), dMePE (18:0/18:1) and dMePE (16:0/20:3) levels (Variable Importance in the Projection; VIP > 1 and p < 0.05). In addition, according to the analysis of metabolic pathway, the pathways of linoleic acid, alpha‐linolenic acid, glycerolipid and glycerophospholipid metabolism were involved in the effects of HS on hepatic lipid metabolism of broilers (p < 0.05). In conclusion, HS altered the hepatic lipid metabolism mainly through linoleic acid, alpha‐linolenic acid, glycerolipid and glycerophospholipid metabolism pathway in indigenous broilers. These findings provided novel insights into the role of HS on hepatic lipidomics in Chinese indigenous broiler chickens.

show abstract

Metabonomic analysis of the hepatic injury suffer from hexavalent chromium poisoning in broilers

Cited by 30 publications

References 27 publications

Effects of embryonic exposure to chromium (VI) on blood parameters and liver microstructure of 1-day-old chickens

Effects of embryonic exposure to chromium (VI) on blood parameters and liver microstructure of 1-day-old chickens

Isolation and Identification of Chromium Reducing Bacillus Cereus Species from Chromium-Contaminated Soil for the Biological Detoxification of Chromium

Hepatic lipid metabolomics in response to heat stress in local broiler chickens breed (Huaixiang chickens)

Contact Info

Product

Resources

About