Metabolomics Study of Serum from a Chronic Alcohol-Fed Rat Model Following Administration of Defatted Tenebrio molitor Larva Fermentation Extract

Choi, Ra-Yeong; Ji, Moongi; Lee, Mi-Kyung; Paik, Man‐Jeong

doi:10.3390/metabo10110436

Cited by 18 publications

(16 citation statements)

References 46 publications

(62 reference statements)

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“…As regards the insects, 35 different species were investigated; the ones that arouse major interest in researchers were T. molitor and those belonging to the Gryllydae family, respectively studied in 13 and 10 different researches. However, it is interesting to note that the experimental studies carried out in vivo are mainly focused on G. bimaculatus, P. brevitaris, and B. mori, while curiously, all the studies performed using T. molitor are in vitro, with only one exception (35).…”

Section: Discussionmentioning

confidence: 99%

“…The ethanolic extracts of Protaetia brevitaris larvae, administered with a high-fat diet for 7 weeks, increased GPx and CAT in liver of obese C57BL/6J mice (34). Finally, the treatment fermented defatted T. molitor powder of Sprague-Dawley rats fed with a chronic alcohol diet dose-dependently increased hepatic β-oxidation (35).…”

Section: Antioxidant Activity Of Edible Insects In Cells and Animal Mmentioning

confidence: 94%

“…Differently from other studies, Dutta et al (18) showed that aqueous extract of Vespa affinis was able to increase the activity of the endogenous antioxidant enzymes catalase (CAT) and glutathione S-transferase (GST) (18). Table 2 summarizes the results obtained on the antioxidant activity of different insects and invertebrates; eight were tested in cellular models (12,13,18,20,(26)(27)(28)(29) and as many in animal models (20,27,(30)(31)(32)(33)(34)(35). For what concerns cellular models, the effects of the water-soluble extract of dung beetles of Onitis sp., mole crickets of Gryllotalpa sp., grasshopper of Caelifera sp.…”

Section: In Vitro Antioxidant Activities Of Edible Insectsmentioning

confidence: 97%

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Dietary Modulation of Oxidative Stress From Edible Insects: A Mini-Review

2021

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Edible insects are proposed as a nutritious and environmentally sustainable alternative source to animal proteins, due to their numerous advantages in terms of reduced ecological impact and high nutritional value. However, the novelty for edible insects relies on the content of bioactive ingredients potentially able to induce a functional effect in the body. The present review summarizes the main findings on the antioxidant properties of edible insects available in the literature. A total of 30 studies involving animals, cell cultures, or in vitro experimental studies evaluating the antioxidant effect of edible insects are presented in this work. When the antioxidant activity was investigated, using a wide variety of in vitro tests and in cellular models, positive results were shown. Dietary supplementation with edible insects was also able to counteract dietary oxidative stress in animal models, restoring the balance of antioxidant enzymes and reducing the formation of oxidation damage markers. On the basis of the reviewed evidences, edible insects might represent a source of novel redox ingredients at low ecological impact able to modulate oxidative stress. However, due to the fact that majority of these evidences have been obtained in vitro and in cellular and animal models, dietary intervention trials are needed to assess the efficacy of edible insect consumption to modulate redox status in humans.

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Section: Discussionmentioning

confidence: 99%

Section: Antioxidant Activity Of Edible Insects In Cells and Animal Mmentioning

confidence: 94%

Section: In Vitro Antioxidant Activities Of Edible Insectsmentioning

confidence: 97%

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Dietary Modulation of Oxidative Stress From Edible Insects: A Mini-Review

2021

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“…Abnormal regulation of FAs has been frequently reported in cardiovascular diseases such as myocardial infarction and hypertrophy [ 6 ]. Studies of serum metabolomics have also demonstrated that free fatty acids can damage biological membranes and are partly responsible for the functional and morphological changes of alcohol-induced diseases [ 10 , 11 ].…”

Section: Discussionmentioning

confidence: 99%

A Pilot Metabolomic Study on Myocardial Injury Caused by Chronic Alcohol Consumption—Alcoholic Cardiomyopathy

et al. 2021

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Chronic alcohol consumption leads to myocardial injury, ventricle dilation, and cardiac dysfunction, which is defined as alcoholic cardiomyopathy (ACM). To explore the induced myocardial injury and underlying mechanism of ACM, the Liber-DeCarli liquid diet was used to establish an animal model of ACM and histopathology, echocardiography, molecular biology, and metabolomics were employed. Hematoxylin-eosin and Masson’s trichrome staining revealed disordered myocardial structure and local fibrosis in the ACM group. Echocardiography revealed thinning wall and dilation of the left ventricle and decreased cardiac function in the ACM group, with increased serum levels of brain natriuretic peptide (BNP) and expression of myocardial BNP mRNA measured through enzyme-linked immunosorbent assay and real-time quantitative polymerase chain reaction (PCR), respectively. Through metabolomic analysis of myocardium specimens, 297 differentially expressed metabolites were identified which were involved in KEGG pathways related to the biosynthesis of unsaturated fatty acids, vitamin digestion and absorption, oxidative phosphorylation, pentose phosphate, and purine and pyrimidine metabolism. The present study demonstrated chronic alcohol consumption caused disordered cardiomyocyte structure, thinning and dilation of the left ventricle, and decreased cardiac function. Metabolomic analysis of myocardium specimens and KEGG enrichment analysis further demonstrated that several differentially expressed metabolites and pathways were involved in the ACM group, which suggests potential causes of myocardial injury due to chronic alcohol exposure and provides insight for further research elucidating the underlying mechanisms of ACM.

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“…A total of twenty-five intervention studies in animal models and two in humans have been published, as described in Table 6. Fifteen different edible insects were investigated: five papers involved Gryllus bimaculatus (6,45,47,51,52) and four Tenebrio molitor (39,48,53,54) , while the use of Oxya chinensis sinuosa (37,47,55) and Protaetia brevitaris seulensis (38,47,49) was reported in three interventions each. One study investigated the effects of both acute and chronic settings, while four were only acute (i.e.…”

Section: Effect Of Edible Insects In Animal and Human Studiesmentioning

confidence: 99%

Functional properties of edible insects: a systematic review

et al. 2021

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Consumption of edible insects has been widely suggested as an environmentally sustainable substitute for meat to reduce GHG emissions. However, the novel research field for edible insects rely on the content of bioactive ingredients and on the ability to induce a functional effect in humans. The goal of this manuscript was to review the available body of evidence on the properties of edible insects in modulating oxidative and inflammatory stress, platelet aggregation, lipid and glucose metabolism and weight control. A search for literature investigating the functional role of edible insects was carried out in the PUBMED database using specific keywords. A total of 55 studies, meeting inclusion criteria after screening, were divided on the basis of the experimental approach: in vitro studies, cellular models/ex vivo studies or in vivo studies. In the majority of the studies, insects demonstrated the ability to reduce oxidative stress, modulate antioxidant status, restore the impaired activity of antioxidant enzymes and reduce markers of oxidative damage. Edible insects displayed anti-inflammatory activity reducing cytokines and modulating specific transcription factors. Results from animal studies suggest that edible insects can modulate lipid and glucose metabolism. The limited number of studies focused on the assessment of anticoagulation activity of edible insects make it difficult to draw conclusions. More evidence from dietary intervention studies in humans is needed to support the promising evidence from in vitro and animal models about the functional role of edible insects consumption.

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Metabolomics Study of Serum from a Chronic Alcohol-Fed Rat Model Following Administration of Defatted Tenebrio molitor Larva Fermentation Extract

Cited by 18 publications

References 46 publications

Dietary Modulation of Oxidative Stress From Edible Insects: A Mini-Review

Dietary Modulation of Oxidative Stress From Edible Insects: A Mini-Review

A Pilot Metabolomic Study on Myocardial Injury Caused by Chronic Alcohol Consumption—Alcoholic Cardiomyopathy

Functional properties of edible insects: a systematic review

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