Metabolomics Reveals Discrimination of Chinese Propolis from Different Climatic Regions

Wang, Tongtong; Liu, Quanhui; Wang, Min; Zhang, Limin

doi:10.3390/foods9040491

Cited by 9 publications

(8 citation statements)

References 43 publications

(64 reference statements)

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“…Proton ( 1 H) NMR has been extensively applied to prepare chemical profiles of various propolis extracts, prepared from the Brazilian, Chinese, Greek and Indian-propolis. In combination with chemometric analysis, these datasets were used to classify propolis samples based on their chemical proximity (Maraschin et al 2016 ; Kasote et al 2017 ; Wang et al 2020 ; Stavropoulou et al 2021 ). A particular advantage of NMR in the chemical characterisation of propolis is that it helps to identify isomeric compounds (Pavlovic et al 2020 ).…”

Section: Analytical Methods Employed In Propolis Quality Controlmentioning

confidence: 99%

Propolis: chemical diversity and challenges in quality control

2022

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Propolis is a resinous natural product produced by honeybees using beeswax and plant exudates. The chemical composition of propolis is highly complex, and varies with region and season. This inherent chemical variability presents several challenges to its standardisation and quality control. The present review was aimed at highlighting marker compounds for different types of propolis, produced by the species Apis mellifera , from different geographical origins and that display different biological activities, and to discuss strategies for quality control. Over 800 compounds have been reported in the different propolises such as temperate, tropical, birch, Mediterranean, and Pacific propolis; these mainly include alcohols, acids and their esters, benzofuranes, benzopyranes, chalcones, flavonoids and their esters, glycosides (flavonoid and diterpene), glycerol and its esters, lignans, phenylpropanoids, steroids, terpenes and terpenoids. Among these, flavonoids (> 140), terpenes and terpenoids (> 160) were major components. A broad range of biological activities, such as anti-oxidant, antimicrobial, anti-inflammatory, immunomodulatory, and anticancer activities, have been ascribed to propolis constituents, as well as the potential of these compounds to be biomarkers. Several analytical techniques, including non-separation and separation methods have been described in the literature for the quality control assessment of propolis. Mass spectrometry coupled with separation methods, followed by chemometric analysis of the data, was found to be a valuable tool for the profiling and classification of propolis samples, including (bio)marker identification. Due to the rampant chemotypic variability, a multiple-marker assessment strategy considering geographical and biological activity marker(s) with chemometric analysis may be a promising approach for propolis quality assessment. Supplementary Information The online version contains supplementary material available at 10.1007/s11101-022-09816-1.

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Section: Analytical Methods Employed In Propolis Quality Controlmentioning

confidence: 99%

Propolis: chemical diversity and challenges in quality control

2022

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“…By introducing an orthogonal signal correction (OSC) filter, variation from X (descriptor variables) was removed to reduce model complexity by orthogonal projection to latent structure-discriminate analysis (OPLS-DA), which is uncorrelated with Y (property variables) to achieve good discrimination for samples [ 34 , 35 ]. In addition, it has always been successfully applied to study metabolomics and CMMs [ 36 – 39 ].…”

Section: Resultsmentioning

confidence: 99%

Study on Closely Related Citrus CMMs based on Chemometrics and Prediction of Components-Targets-Diseases Network by Ingenuity Pathway Analysis

Zhang

Cui

et al. 2022

Evidence-Based Complementary and Alternative Medicine

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As the representatives of closely related Chinese medicinal materials (CMMs) originated from Rutaceae family, Aurantii fructus immaturus (AFI), Aurantii fructus (AF), Citri reticulatae pericarpium viride (CRPV), and Citri reticulatae pericarpium (CRP) have better functions in regulating qi and promoting gastrointestinal motility. However, differences in the quality of closely related Citrus CMMs have not yet been revealed until now. Herein, this study focused on the systematic differentiation and in-depth understanding of closely related Citrus CMMs by a strategy integrating chemometrics and network pharmacology. Determined by ultra performance liquid chromatography, the content of nine flavonoids showed obvious fluctuations in the decoction pieces from different species (Citrus aurantium Linnaeus and Citrus reticulate Blanco) with decreasing levels in the samples of ripe fruits. Decoction pieces from the different species and ripening stages were well distinguished by orthogonal projection to latent structure-discriminate analysis (OPLS-DA) and cluster analysis. As a result, four active components including narirutin, naringenin, hesperidin, and 3,5,6,7,8,3′,4′-heptemthoxyflavone were filtered out by variable importance for the projection (VIP) value (VIP > 1.0), which were regarded as chemotaxonomic markers. Furthermore, a components-targets-diseases network was constructed via ingenuity pathway analysis (IPA), and the correlations were predicted between four chemotaxonomic markers, 223 targets, and three diseases including colitis, breast cancer, and colorectal cancer. The obtained results will be of great significance for identifying closely related Citrus CMMs and conduce to improving the resource utilization of CMMs.

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“…However, there is increasing interest in the use of NMR, the application of which has experienced exponential growth in several research fields, particularly food science, for geographical origin characterization, aging analysis, and fraud detection ( Consonni & Cagliani, 2019 ). For example, NMR has been used to profile other beehive products such as honey and propolis ( Maraschin et al, 2016 , Schievano et al, 2016 , Wang et al, 2020 ). To the best of our knowledge, although solid-state NMR analysis of bee pollen has been reported ( Paradowska et al, 2017 ), there have been no studies on the component profiling of liquid bee pollen extracts by NMR.…”

Section: Discussionmentioning

confidence: 99%