Metabolomics of male infertility

Victor Oluwaloseyi, Amos; Aduragbemi Noah, Odeyemi; Lydia Oluwatoyin, Ajayi; Gaffar, Yusuff; Moses, Olotu; Oyedayo Phillips, Akano; Comfort Onaolapo, Moyinoluwa; Sylvester Olateju, Bolade; Ademola Ayodele, Adelakun; Mega Obukohwo, Oyowvi; Ayodeji Folorunsho, Ajayi

doi:10.1016/j.cca.2024.117850

Clinica Chimica Acta

2024

DOI: 10.1016/j.cca.2024.117850

|View full text |Cite

Metabolomics of male infertility

Amos Victor Oluwaloseyi,

Odeyemi Aduragbemi Noah,

Ajayi Lydia Oluwatoyin

et al.

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

Supporting

Mentioning

Contrasting

Year Published

2024

Publication Types

Select...

Article1

Relationship

Self Cite0

Independent1

Authors

Journals

Cited by 1 publication

References 99 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

The Role of One-Carbon Metabolism and Methyl Donors in Medically Assisted Reproduction: A Narrative Review of the Literature

Sfakianoudis,

Zikopoulos,

Grigoriadis

et al. 2024

IJMS

View full text Add to dashboard Cite

One-carbon (1-C) metabolic deficiency impairs homeostasis, driving disease development, including infertility. It is of importance to summarize the current evidence regarding the clinical utility of 1-C metabolism-related biomolecules and methyl donors, namely, folate, betaine, choline, vitamin B12, homocysteine (Hcy), and zinc, as potential biomarkers, dietary supplements, and culture media supplements in the context of medically assisted reproduction (MAR). A narrative review of the literature was conducted in the PubMed/Medline database. Diet, ageing, and the endocrine milieu of individuals affect both 1-C metabolism and fertility status. In vitro fertilization (IVF) techniques, and culture conditions in particular, have a direct impact on 1-C metabolic activity in gametes and embryos. Critical analysis indicated that zinc supplementation in cryopreservation media may be a promising approach to reducing oxidative damage, while female serum homocysteine levels may be employed as a possible biomarker for predicting IVF outcomes. Nonetheless, the level of evidence is low, and future studies are needed to verify these data. One-carbon metabolism-related processes, including redox defense and epigenetic regulation, may be compromised in IVF-derived embryos. The study of 1-C metabolism may lead the way towards improving MAR efficiency and safety and ensuring the lifelong health of MAR infants.

show abstract

The Role of One-Carbon Metabolism and Methyl Donors in Medically Assisted Reproduction: A Narrative Review of the Literature

Sfakianoudis,

Zikopoulos,

Grigoriadis

et al. 2024

IJMS

View full text Add to dashboard Cite

show abstract

scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.

Contact Info

hi@scite.ai

10624 S. Eastern Ave., Ste. A-614

Henderson, NV 89052, USA

Blog Terms and Conditions API Terms Privacy Policy Contact Cookie Preferences Do Not Sell or Share My Personal Information

Made with 💙 for researchers

Part of the Research Solutions Family.

Metabolomics of male infertility

Cited by 1 publication

References 99 publications

The Role of One-Carbon Metabolism and Methyl Donors in Medically Assisted Reproduction: A Narrative Review of the Literature

The Role of One-Carbon Metabolism and Methyl Donors in Medically Assisted Reproduction: A Narrative Review of the Literature

Contact Info

Product

Resources

About