Metabolomics Investigation To Shed Light on Cheese as a Possible Piece in the French Paradox Puzzle

Zheng, Hong; Yde, Christian Clement; Clausen, Morten Rahr; Kristensen, Mette; Lorenzen, Janne Kunchel; Astrup, Arne; Bertram, Hanne Christine

doi:10.1021/jf505878a

Cited by 86 publications

(70 citation statements)

References 46 publications

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“…Both are aromatic amino acids that are more abundant in cheese products than butter, thereby most likely the source for the observed increase of their metabolites in urine. This study, however, did not report any change in the urinary hippuric acid levels, most likely reflecting the differences in the study design and products used when compared to the study conducted by Zheng et al [58].…”

Section: Dietary Interventions With Selected Foodscontrasting

confidence: 64%

“…An NMR-based metabolomics approach was used to investigate the differentiation in urine and fecal samples between subjects consuming cheese or milk and to elucidate the potential link to an effect on blood cholesterol level [58]. Three dietary groups were included: group high in milk, high in cheese with equal amounts of dairy calcium, and a control diet.…”

Section: Dietary Interventions With Selected Foodsmentioning

confidence: 99%

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Application of Metabolomics to Assess Effects of Controlled Dietary Interventions

Hanhineva

2015

Curr Nutr Rep

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The utilization of metabolomics technologies as part of nutritional investigations has rapidly increased during the last few years. The application of both nuclear magnetic resonance (NMR) and mass spectrometry (MS) based technologies is providing wide information on both the dietderived compounds and their metabolites related to specific foods or diets, as well as aiding the in-depth exploration of the endogenous metabolic phenomena related to different diets. The analytical accuracy nowadays enables examination of metabolite composition of both urine and plasma to very high molecular detail even at low concentrations, and will be focal in gaining wider metabolic understanding of the relationship between eating habits and maintenance of good health.

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Section: Dietary Interventions With Selected Foodscontrasting

confidence: 64%

Section: Dietary Interventions With Selected Foodsmentioning

confidence: 99%

Application of Metabolomics to Assess Effects of Controlled Dietary Interventions

Hanhineva

2015

Curr Nutr Rep

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“…This could be a possible mechanism of lipid reduction. Similarly, in another metabolic study conducted in human subjects, cheese (casein) appeared to induce lowering of urinary citrate (122) , which suggests that cheese consumption affects the tricarboxylic acid cycle. Additionally, microbiota-related metabolite, hippuric acid was significantly higher in the cheese group, than in the milk, implying (82) Healthy (n 9) 180 min WP (48 g) Casein ↑GLP-1 Veldhorst et al (83) Healthy (n 25) 180 min WP (10 and 25 %) Casein, soya ↑GLP-1 Petersen et al (90) Healthy (n 10) 120 min WP (20 g) Glucose ↓Glucose response Pal and Ellis (91) Healthy men (n 22) 240 min WP (50·8 g) Turkey, egg, tuna ↓Glucose response, ↑Insulin response Akhavan et al (92) Healthy (n 10) 230 min WP as pre-meal (10-20 g)…”

Section: Long-term Studies On Lipidsmentioning

confidence: 72%

“…The enhanced bacterial activity also resulted in higher SCFA (122) , which have been proposed as key regulatory metabolites in lipid metabolism (123) . This effect may be due to the cheese matrix rather than the casein per se.…”

Section: Long-term Studies On Lipidsmentioning

confidence: 99%

Can milk proteins be a useful tool in the management of cardiometabolic health? An updated review of human intervention trials

2016

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The prevalence of cardiometabolic diseases is a significant public health burden worldwide. Emerging evidence supports the inverse association between greater dairy consumption and reduced risk of cardiometabolic diseases. Dairy proteins may have an important role in the favourable impact of dairy on human health such as blood pressure (BP), blood lipid and glucose control. The purpose of this review is to update and critically evaluate the evidence on the impacts of casein and whey protein in relation to metabolic function. Evidence from short-term clinical studies assessing postprandial responses to milk protein ingestion suggests benefits on vascular function independent of BP, as well as improvement in glycaemic homeostasis. Long-term interventions have been less conclusive, with some showing benefits and others indicating a lack of improvement in vascular function. During chronic consumption BP appears to be lowered and both dyslipidaemia and hyperglacaemia seem to be controlled. Limited number of trials investigated the effects of dairy proteins on oxidative stress and inflammation. Although the underlying mechanisms of milk proteins on cardiometabolic homeostasis remains to be elucidated, the most likely mechanism is to improve insulin resistance. The incorporation of meals enriched with dairy protein in the habitual diet may result in the beneficial effects on cardiometabolic health. Nevertheless, future well-designed, controlled studies are needed to investigate the relative effects of both casein and whey protein on BP, vascular function, glucose homeostasis and inflammation.

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“…Values of R 2 Y and Q 2 close to 1.0 represent an excellent model. Furthermore, the significance of the models was tested by CV-ANOVA in the SIMCA software [25].…”

Section: Acquisition Of 1 H-nmr Spectra and Multivariate Pattern Recomentioning

confidence: 99%

Identification of Energy Metabolism Changes in Diabetic Cardiomyopathy Rats Using a Metabonomic Approach

Zhao

Dong

et al. 2018

Cell Physiol Biochem

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Background/Aims: Diabetic cardiomyopathy (DCM) is a serious complication of diabetes. It is therefore crucial to elucidate the characteristic metabolic changes that occur during the development of diabetes to gain an understanding the pathogenesis of this disease and identify potential drug targets involved. Methods: ¹H nuclear magnetic resonance-based metabonomics combined with HPLC measurements were used to determine the metabolic changes in isolated cardiac tissues after 5 weeks, 9 weeks, and 15 weeks in rats treated with streptozotocin. Results: Pattern recognition analysis clearly discriminated the diabetic rats from time-matched control rats, suggesting that the metabolic profile of the diabetic group was markedly different from that of the controls. Quantitative analysis showed that the levels of energy metabolites, such as the high-energy phosphate pool (ATP and creatine), significantly decreased in a time-dependent manner. Correlation analysis revealed the inhibition of glycolysis and the tricarboxylic acid (TCA) cycle, enhanced lipid metabolism, and changes in some amino acids, which may have led to the decline in energy production in the DCM rats. Conclusions: The results indicated that the administration of energy substances or the manipulation of myocardial energy synthesis induced by increased glucose oxidation may contribute to the amelioration of cardiac dysfunction in diabetes.

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Metabolomics Investigation To Shed Light on Cheese as a Possible Piece in the French Paradox Puzzle

Cited by 86 publications

References 46 publications

Application of Metabolomics to Assess Effects of Controlled Dietary Interventions

Application of Metabolomics to Assess Effects of Controlled Dietary Interventions

Can milk proteins be a useful tool in the management of cardiometabolic health? An updated review of human intervention trials

Identification of Energy Metabolism Changes in Diabetic Cardiomyopathy Rats Using a Metabonomic Approach

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