Metabolomics in Team-Sport Athletes: Current Knowledge, Challenges, and Future Perspectives

Bongiovanni, Tindaro; Lacome, Mathieu; Fanos, Vassilios; Martera, Giulia; Cione, Erika; Cannataro, Roberto

doi:10.3390/proteomes10030027

Cited by 7 publications

(10 citation statements)

References 66 publications

(82 reference statements)

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“…Adherence to nutritional guidelines for both match-day and post-match recovery, and the standardization of training loads are key for achieving this goal ( Mohr et al, 2016 ). These studies would also benefit from evaluating non-invasive samples such as saliva and urine to improve the applicability to real-world conditions ( Bongiovanni et al, 2022 ). Additionally, systematic analyses have shown that sex plays an important role in driving differences in metabolomic profiles, thus representing an important factor to consider in football studies ( Costanzo et al, 2022 ).…”

Section: Future Perspectivesmentioning

confidence: 99%

Biomarkers of post-match recovery in semi-professional and professional football (soccer)

et al. 2023

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High-level football (soccer) players face intense physical demands that result in acute and residual fatigue, impairing their physical performance in subsequent matches. Further, top-class players are frequently exposed to match-congested periods where sufficient recovery times are not achievable. To evaluate training and recovery strategies, the monitoring of players’ recovery profiles is crucial. Along with performance and neuro-mechanical impairments, match-induced fatigue causes metabolic disturbances denoted by changes in chemical analytes that can be quantified in different body fluids such as blood, saliva, and urine, thus acting as biomarkers. The monitoring of these molecules might supplement performance, neuromuscular and cognitive measurements to guide coaches and trainers during the recovery period. The present narrative review aims to comprehensively review the scientific literature on biomarkers of post-match recovery in semi-professional and professional football players as well as provide an outlook on the role that metabolomic studies might play in this field of research. Overall, no single gold-standard biomarker of match-induced fatigue exists, and a range of metabolites are available to assess different aspects of post-match recovery. The use of biomarker panels might be suitable to simultaneously monitoring these broad physiological processes, yet further research on fluctuations of different analytes throughout post-match recovery is warranted. Although important efforts have been made to address the high interindividual heterogeneity of available markers, limitations inherent to these markers might compromise the information they provide to guide recovery protocols. Further research on metabolomics might benefit from evaluating the long-term recovery period from a high-level football match to shed light upon new biomarkers of post-match recovery.

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Section: Future Perspectivesmentioning

confidence: 99%

Biomarkers of post-match recovery in semi-professional and professional football (soccer)

et al. 2023

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“…Metabolomics, a facet of 'omics' science that extensively measures small metabolites in biological samples, has become increasingly prominent in sports medicine (15,34). Termed "sportomics," this approach is crucial in studying exercise physiology and metabolism.…”

Section: Use Of Big Data In Metabolomicsmentioning

confidence: 99%

“…Termed "sportomics," this approach is crucial in studying exercise physiology and metabolism. The integration of big data in metabolomics is significantly enhancing our comprehension of athletes' physiological responses to exercise (34).…”

Section: Use Of Big Data In Metabolomicsmentioning

confidence: 99%

Big Data in Sports Medicine and Exercise Science: Integrating Theory and Practice for Future Innovations

Dergaa,

Chamari

2024

TJSSM

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Background: Big data has been successfully applied in medicine, offering remarkable advancements in patient care and health management. The rise of big data in sports medicine and exercise science is a pivotal development, offering fresh perspectives on optimizing athlete performance, preventing injuries, and managing non-communicable diseases (NCDs). This review explores the integration and the potential of big data in these areas, with a particular focus on wearables, genomics, and metabolomics. Objectives: The objectives of this study were: (i) to present the current state of big data in sports medicine, including its applications and advancements in wearables, genomics, and metabolomics, and (ii) to outline the future prospects of big data in sports medicine and exercise science, emphasizing a call to action for ongoing research and interdisciplinary collaboration. Methods: An extensive review of the existing literature and current practices in the application of big data in sports medicine was conducted. The review concentrated on the advancements and applications in the fields of wearables, genomics, and metabolomics, and their implications for sports science and health management. Results: The application of big data has significantly influenced sports medicine, particularly through advanced wearable technologies for monitoring physiological parameters, genomic approaches for personalized athlete care, and metabolomics for in-depth analysis of metabolic responses to exercise. These developments have led to more individualized training and rehabilitation programs, effective injury prevention strategies, and better health management practices for both athletes and the general population. Conclusion: The integration of big data into sports medicine signifies a substantial shift towards more data-driven and tailored approaches. This progression fosters interdisciplinary collaboration and opens new avenues for research in areas like biomechanics and transcriptomics. Leveraging these opportunities can lead to practical improvements in athlete care, health management, and a broader understanding of sports science, benefiting both the sports community and the wider public.

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“…Exercise can potentially impact the human metabolome ( 1 , 2 ). The application of “-Omics” sciences in the field of play of various sports was conceived as sportomics, aiming to investigate the real challenges athletes face, using sports as a model of metabolic stress ( 3 , 4 ). Sportomics, like all “-Omics” sciences, depends on analytical methods with high processing power to analyze massive volumes of data and is a promising field of investigation ( 5 ).…”

Section: Introductionmentioning

confidence: 99%

A sportomics soccer investigation unveils an exercise-induced shift in tyrosine metabolism leading to hawkinsinuria

et al. 2023

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Tyrosine metabolism has an intense role in the synthesis of neurotransmitters. Our study used an untargeted, sportomics-based analysis of urine samples to investigate changes in metabolism during a soccer match in 30 male junior professional soccer players. Samples were collected before and after the match and analyzed using liquid chromatography and mass spectrometry. Results showed significant changes in tyrosine metabolism. Exercise caused a downregulation of the homogentisate metabolites 4-maleylacetoacetate and succinylacetone to 20% (p = 4.69E−5) and 16% (p = 4.25E−14), respectively. 4-Hydroxyphenylpyruvate, a homogentisate precursor, was found to be upregulated by 26% (p = 7.20E−3). The concentration of hawkinsin and its metabolite 4-hydroxycyclohexyl acetate increased ~six-fold (p = 1.49E−6 and p = 9.81E−6, respectively). Different DOPA metabolism pathways were also affected by exercise. DOPA and dopaquinone increased four-to six-fold (p = 5.62E−14 and p = 4.98E−13, respectively). 3-Methoxytyrosine, indole-5,6-quinone, and melanin were downregulated from 1 to 25%, as were dopamine and tyramine (decreasing to up to 5% or 80%; p= 5.62E−14 and p = 2.47E−2, respectively). Blood TCO2 decreased as well as urinary glutathione and glutamate (40% and 10% respectively) associated with a two-fold increase in pyroglutamate. Our study found unexpected similarities between exercise-induced changes in metabolism and the inherited disorder Hawkinsinuria, suggesting a possible transient condition called exercise-induced hawkinsinuria (EIh). Additionally, our research suggests changes in DOPA pathways may be involved. Our findings suggest that soccer exercise could be used as a model to search for potential countermeasures in Hawkinsinuria and other tyrosine metabolism disorders.

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Metabolomics in Team-Sport Athletes: Current Knowledge, Challenges, and Future Perspectives

Cited by 7 publications

References 66 publications

Biomarkers of post-match recovery in semi-professional and professional football (soccer)

Biomarkers of post-match recovery in semi-professional and professional football (soccer)

Big Data in Sports Medicine and Exercise Science: Integrating Theory and Practice for Future Innovations

A sportomics soccer investigation unveils an exercise-induced shift in tyrosine metabolism leading to hawkinsinuria

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