Metabolomics in premature labor: A novel approach to identify patients at risk for preterm delivery

Romero, Roberto; Gómez, Ricardo; Nien, Jyh Kae; Yoon, Bo Hyun; Luo, Rui; Beecher, Chris; Mazor, Moshe

doi:10.1016/j.ajog.2004.09.036

Cited by 31 publications

(33 citation statements)

References 51 publications

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“…We have read with great interest the article by Romero R, et al about a preliminary study of metabolomics in premature labor [1]. The authors state that metabolic profiling of the amniotic fluid can be used to assess the risk of preterm delivery in the presence or absence of infection/inflammation.…”

Section: Comment and Reply On: Metabolomics Of Amniotic Fluid And Prementioning

confidence: 94%

“…We would like to thank Dr. Dokos and Dr. Tsakalidis for their interest in our work and publication describing a study of metabolomics to identify biomarkers in the amniotic fluid of women in preterm labor which predict outcome in the presence or absence of intra-amniotic infection/inflammation [1]. Metabolomics and other high-dimensional biology approaches (genomics, transcriptomics, metabolomics, lipidomics, glycomics, etc.)…”

Section: Author's Replymentioning

confidence: 99%

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Comment and reply on: Metabolomics of amniotic fluid and preterm delivery

Dokos

Tsakalidis

2011

The Journal of Maternal-Fetal & Neonatal Medicine

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Section: Comment and Reply On: Metabolomics Of Amniotic Fluid And Prementioning

confidence: 94%

Section: Author's Replymentioning

confidence: 99%

Comment and reply on: Metabolomics of amniotic fluid and preterm delivery

Dokos

Tsakalidis

2011

The Journal of Maternal-Fetal & Neonatal Medicine

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“…A decrease in carbohydrates was associated with preterm delivery in the presence or absence of inflammation whereas an increase in amino acid metabolites was a unique feature of preterm labor with inflammation [6].…”

Section: Preterm Birth and Postnatal Maturationmentioning

confidence: 99%

Metabolomics in Neonatology

Hanna¹,

Brophy²

2016

Metabolomics - Fundamentals and Applications

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Throughout recent decades, the incidence of preterm birth has risen worldwide, and although the majority of preterm neonates now survive infancy, many suffer from debilitating morbidities in the short term and/or increased disease risks in the long term. Traditional diagnostic biomarkers suffer from considerable confounders, limiting their use in the early identification of diseases. There is a need to develop novel biomarkers that can identify, in real time, the evolution of organ dysfunction in an early diagnostic, monitoring, and prognostic fashion. Use of "omics," particularly metabolomics, may provide valuable information regarding functional pathways underlying different pathologies and prediction of clinical outcomes. The emerging knowledge generated by the application of metabolomics in neonatology provides new insights that can help to identify markers of early diagnosis, disease progression, response to treatment, and new therapeutic targets. In this chapter, we review the current knowledge of different metabolomics technologies in neonatal-perinatal medicine, including biomarker discovery, defining as yet unrecognized biologic therapeutic targets, and linking of metabolomics to relevant standard indices and long-term outcomes.

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“…To understand what triggers the time of delivery, what series of events and metabolites press the button of no return, that is, the beginning of delivery, is a challenge that may lead to unimaginable advantages and it is no coincidence that important obstetricians of global renown are pressing on the accelerator of metabolomics [4]. This technique seems of outstanding impact on perinatology [5].…”

mentioning

confidence: 99%