Metabolomics in diagnosis and biomarker discovery of colorectal cancer

Zhang, Aihua; Sun, Hui; Ge, Yan; Wang, Ping; Han, Ying; Wang, Xijun

doi:10.1016/j.canlet.2013.11.011

Cited by 162 publications

(111 citation statements)

References 49 publications

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“…Metabolomics seeks to elucidate the therapeutic properties and metabolism of prescription drugs and the metabolic pathways involved [81][82][83][84][85][86][87][88][89][90][91][92]. It will greatly facilitate understanding of the mechanisms of action of TCMs [93][94][95][96][97][98][99][100][101][102].…”

Section: Metabolomicsmentioning

confidence: 99%

UHPLC-MS for the analytical characterization of traditional Chinese medicines

Wang

Zhang

et al. 2014

TrAC Trends in Analytical Chemistry

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Section: Metabolomicsmentioning

confidence: 99%

UHPLC-MS for the analytical characterization of traditional Chinese medicines

Wang

Zhang

et al. 2014

TrAC Trends in Analytical Chemistry

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“…Metabonomics is an approach that is used to detect and provide comprehensive information on changes to metabolites and to reveal critical mechanisms involved in certain diseases or drug toxicities [3][4][5]. To date, a number of scientific studies have identified abundant and varied classifications of endogenous metabolites in biological samples, e.g.…”

Section: Introductionmentioning

confidence: 99%

A novel approach to the simultaneous extraction and non-targeted analysis of the small molecules metabolome and lipidome using 96-well solid phase extraction plates with column-switching technology

Zhang

Liu

et al. 2015

Journal of Chromatography A

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“…However, early diagnosis of CRC is challenging, as marked symptoms only appear in the period of disease progression. Therefore, most patients are diagnosed at a late stage (2). As a result, only radical resection of the tumor improves the clinical prognosis and provides a chance to prolong survival.…”

Section: Introductionmentioning

confidence: 99%

“…Due to its high throughput, sensitivity and non-invasiveness, metabonomic analysis has already been used as A diagnostic tools in numerous human diseases, including diabetes (7), cancer (8), cardiovescular disease (9) and respiratory disease (10). Although a growing amount of research has provided experimental and clinical evidence for the close association between specific biomarkers and diagnosis of certain types of cancer, including CRC (1,2,4), the application of metabonomic analysis to post-operative monitoring of CRC has rarely been reported (11).…”

Section: Introductionmentioning

confidence: 99%

Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry-based metabolic profiling of human serum prior to and following radical resection of colorectal carcinoma

Chen

Zhang

Gui

et al. 2015

Molecular Medicine Reports

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Abstract. Nearly one quarter of patients with colorectal carcinoma (CRC) were diagnosed at an advanced stage. Under these circumstances, radical resection of the tumor is the best strategy to enhance the five-year survival rate. However, up to 50% of post-operative patients experience cancer recurrence within the first few years. Therefore, post-operative surveillance is important. However, currently performed post-operative monitoring relies on relatively dated methods with insufficient sensitivity and specificity. The present study applied an advanced technology of ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry in order to examine changes in metabolite patterns in serum with the aim of identifying reliable biomarkers in patients with CRC at various time-points. Serum samples were collected from and 20 CRC patients prior to radical resection (group 1) and one month following radical resection (group 2) as well as from 20 healthy volunteers (group 3). Multivariate pattern recognition was used to identify potential biomarkers of CRC. Compared with healthy volunteers, three groups of biomarkers were identified in patients with CRC (P<0.05), namely phosphatidylcholines (PCs), lysophosphatidylcholines (LPCs) and diacylglycerols (DAGs). However, no statistical difference in the levels of these biomarkers between pre-operative and post-operative CRC patients was identified (P>0.05). PCs and LPCs, which contain polyunsaturated fatty acids, were decreased, whereas LPCs and DAGs, which contain saturated fatty acids, were increased in CRC patients. The present study demonstrated that obvious metabolic disturbances occur during the development of CRC and provided a novel analytic method, which is likely to be used as a diagnostic tool for CRC and may help to improve the patients' prognosis.

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Metabolomics in diagnosis and biomarker discovery of colorectal cancer

Cited by 162 publications

References 49 publications

UHPLC-MS for the analytical characterization of traditional Chinese medicines

UHPLC-MS for the analytical characterization of traditional Chinese medicines

A novel approach to the simultaneous extraction and non-targeted analysis of the small molecules metabolome and lipidome using 96-well solid phase extraction plates with column-switching technology

Ultra-performance liquid chromatography coupled with quadrupole time-of-flight mass spectrometry-based metabolic profiling of human serum prior to and following radical resection of colorectal carcinoma

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