Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies

Abstract

According to current trials in women undergoing ART, there is no evidence to show that metabolomic assessment of embryos before implantation has any meaningful effect on rates of live birth, ongoing pregnancy, miscarriage, multiple pregnancy, ectopic pregnancy or foetal abnormalities. The existing evidence varied from very low to low-quality. Data on other adverse events were sparse, so we could not reach conclusions on these. At the moment, there is no evidence to support or refute the use of this technique for subfertile women undergoing ART. Robust evidence is needed from further RCTs, which study the effects on live birth and miscarriage rates for the metabolomic assessment of embryo viability. Well designed and executed trials are also needed to study the effects on oocyte quality and endometrial receptivity, since none are currently available.

Omics and Artificial Intelligence to Improve In Vitro Fertilization (IVF) Success: A Proposed Protocol

“…Several reports have demonstrated that analyzing all small molecules used and metabolized by the embryo [ 12 , 13 , 14 , 15 , 16 , 17 ] can help in the most appropriate embryo selection. On the other hand, robust answers from high-quality research cannot be pooled to date [ 18 ].…”

Metabolomics for Diagnosis and Prognosis of Uterine Diseases? A Systematic Review

“…Disagreements were discussed and consensus was reached. Studies on metabolomics in reproductive medicine were reviewed relatively recently [ 62 , 63 ], and thus in the present analysis all reports on metabolomics in follicular fluid were excluded. Metabolomic studies performed in cell lines were out of the scope of this review, and so were also excluded.…”

“… * Studies in follicular fluid focusing on infertility and reports on metabolomics in reproductive medicine have been reviewed relatively recently by Bracewell-Milnes et al [ 62 ] and Siristatidis et al [ 63 ]. ** These studies were out of the scope of our review.…”

Endometrial polyps with increased plasma cells are associated with chronic endometritis in infertility patients: Hysteroscopic findings and post‐polypectomy pregnancy rates

“… 4 , 5 Although fertilization rates have improved with intracytoplasmic sperm injection (ICSI), implantation rates have remained unchanged. 5 , 6 …”