Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies

Siristatidis, Charalampos; Vogiatzi, Paraskevi; Varounis, Christos; Vaidakis, Dennis; Trivella, Marialena

doi:10.1002/14651858.cd011872

Cited by 9 publications

(8 citation statements)

References 39 publications

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“…By using different analytical strategies, metabolomics can be employed to reflect the phenotype properties through quantification as more metabolites as possible in a given biological sample 12 . In the life science arena, metabolomics analysis has exhibited its unique advantages in disease stratification, new biomarker discovery and disease prognosis [12][13][14][15] .…”

Section: Disease Diagnosis In Westernmentioning

confidence: 99%

Syndrome differentiation of chronic hepatitis B patients by integrating routine clinical laboratory and plasma metabolomics analysis data

Huang

Guo²,

Hang-yu³

et al. 2020

MRAJ

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Purpose: Traditional Chinese Medicines (TCMs) has been officially approved for chronic hepatitis B infection treatment in China. Correct syndrome differentiation is the key prerequisite for rational prescribing TCMs. Unfortunately, TCM physicians have scarcities of objective measures for syndrome differentiation and their diagnosis exclusively relies on individual experience. This study aimed to find out some objective parameters to aid syndrome differentiation. Methods: Three commonly encountered clinical syndromes named accumulated dampness-heat syndrome (ADHS), spleen deficiency with liver depression (SDLD) and blood stasis vessel obstruction syndrome (BSVO) were selected. 64 qualified patients with definite syndromes were enrolled and their plasma amino acids and lipids were profiled by metabolomics analysis. Additionally, their routine clinical laboratory parameters were also collected. Results: Through orthogonal partial least squares-discriminant analysis, the three syndromes could be properly differentiated. The differential parameters between every two syndromes were screened out. Most of them were of the small molecular metabolites. A distinct difference was found between ADHS and the other two syndromes. BSVO and SDLD showed relatively less discrepancy. Furthermore, it was deduced that sphingomyelin metabolism might dominate ADHS phenotype, and platelet functions might affect SDLD phenotype to some extent. Conclusions: These findings provided primary evidence for the objective classification of varied syndromes of chronic hepatitis B patients and proved that metabolomics analysis might be a valuable tool to aid syndrome differentiation in some circumstances.

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Section: Disease Diagnosis In Westernmentioning

confidence: 99%

Syndrome differentiation of chronic hepatitis B patients by integrating routine clinical laboratory and plasma metabolomics analysis data

Huang

Guo²,

Hang-yu³

et al. 2020

MRAJ

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“…Metabolomics has been proposed as a non-invasive method to assess oocyte quality, embryo viability, and endometrial receptivity (26). Metabolomics is defined as the non-targeted identification and quantification of all low molecular weight end-products of metabolism (metabolites).…”

Section: B Embryologymentioning

confidence: 99%

Single embryo transfer: Why and how to identify the embryo with the best developmental potential

Tiitinen

2019

Best Practice & Research Clinical Endocrinology & Metab

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Multiple pregnancies with higher risk of preterm birth and the associated higher morbidity have been a major obstacle from the early days of in vitro fertilization. A good strategy to avoid multiple pregnancies is elective single embryo transfer and cryopreservation of spare embryos. Important factors in adopting this strategy are good counselling of the patients and the selection of embryos with high implantation potential. Technical advances in embryo selection have been described during recent years, time lapse monitoring and genetic assessment of the embryos being the most important achievements. With these studies we have gained new information on early embryos. However, at present, there is insufficient evidence to recommend the routine use of these new techniques. The ultimate goal of infertility treatment is a healthy baby.

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“…There is an increasing trend for women of reproductive age around the world to experience fertility problems (Fisch & Abir, 2018). Fortunately, technology for assisted reproduction is now well established than before to assist women with infertility (Siristatidis, Sertedaki, Vaidakis, Varounis, & Trivella, ). Researchers and healthcare providers recommend addressing the preventable causes of infertility, providing support and alternatives for women with infertility through intervention, and improving availability, affordability, and acceptability of assisted reproduction technology around the globe (Inhorn & Patrizio, ).…”

Section: Background and Significancementioning

confidence: 99%

“…Other studies indicate both women with breast cancer and health professionals should review the risks of infertility, and health professional should refer these women for fertility counseling before treatment (Goossens et al., ; Kim et al., ). The techniques of selective fertility preservation including ovarian suppression, embryo cryopreservation, oocyte cryopreservation, and ovarian tissue cryopreservation and transplantation should be clearly explained to women before cancer treatment begins (Siristatidis et al., ).…”

Section: Background and Significancementioning

confidence: 99%

Oncofertility to Evidence‐Based Practice: Changes in Fertility Intention and Symptom Burden in Reproductive‐Age Women With Breast Cancer

Huang

Tseng

Lai

et al. 2019

Worldviews Ev Based Nurs

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Background: Infertility is negatively related to the quality of life in reproductive-age women with breast cancer. The nurses who care for these patients lack a comprehensive understanding of the changes in fertility intention that patients undergo from the time of cancer diagnosis, throughout treatment, and after treatment. A fertility intention assessment is the first step in discerning the patient's ideas toward future pregnancy.Aims: This study examined the changes in fertility intention and symptom burden in reproductive-age women with breast cancer before, during, and after treatment. We also explored predictors of fertility intention among the women.

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Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies

Abstract: Metabolomics for improving pregnancy outcomes in women undergoing assisted reproductive technologies.

Cited by 9 publications

References 39 publications

Syndrome differentiation of chronic hepatitis B patients by integrating routine clinical laboratory and plasma metabolomics analysis data

Syndrome differentiation of chronic hepatitis B patients by integrating routine clinical laboratory and plasma metabolomics analysis data

Single embryo transfer: Why and how to identify the embryo with the best developmental potential

Oncofertility to Evidence‐Based Practice: Changes in Fertility Intention and Symptom Burden in Reproductive‐Age Women With Breast Cancer

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