Metabolomics-based mechanisms exploration of Huang-Lian Jie-Du decoction on cerebral ischemia via UPLC-Q-TOF/MS analysis on rat serum

Zhu, Baojie; Cao, Huiting; Sun, Limin; Лі, Бо; Li-wei, Guo; Duan, Jin‐Ao; Zhu, Hua; Zhang, Qichun

doi:10.1016/j.jep.2018.01.015

Cited by 38 publications

(25 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cholestatic injury was associated with inflammation, and our previous study has demonstrated anti-inflammatory effects of HLJDD both in vitro and in vivo (Lu et al, 2011 ). HLJDD, its main herb and representative components have been indicated to possess therapeutic potential in the treatment of stroke (Wang et al, 2013 , 2014 ; Zhang et al, 2015 , 2016 , 2017a , b ; Zhu et al, 2018 ), chronic cholestasis injury (Wei et al, 2015 ) and multiple organ failure during sepsis (Liao et al, 2016a ; Li et al, 2017 ; Lv et al, 2017 ; Xu et al, 2017 ). Herein the aim of the present work was to comparatively study the two cholestatic injuries induced by thioacetamide and by bile duct ligation, and their treatment by HLJDD using an NMR-based metabolomic approach.…”

Section: Introductionmentioning

confidence: 99%

Metabolomic Assessment of Acute Cholestatic Injuries Induced by Thioacetamide and by Bile Duct Ligation, and the Protective Effects of Huang-Lian-Jie-Du-Decoction

et al. 2018

View full text Add to dashboard Cite

Huang-Lian-Jie-Du-Decoction, a traditional Chinese formula, has been reported to protect liver from various injuries. Two cholestasis models of rats induced by thioacetamide and by bile duct ligation were established and treated with Huang-Lian-Jie-Du-Decoction. Nuclear Magnetic Resonance-based urinary metabolic profiles were analyzed by orthogonal partial least squares discriminant analysis and univariate analysis to excavate differential metabolites associated with the injuries of the two models and the treatment effects of Huang-Lian-Jie-Du-Decoction. The two cholestatic models shared common metabolic features of excessive fatty acid oxidation, insufficient glutathione regeneration and disturbed gut flora, with specific characteristics of inhibited urea cycle and DNA damage in thioacetamide-intoxicated model, and perturbed Kreb's cycle and inhibited branched chain amino acid oxidation in bile duct ligation model. With good treatment effects, Huang-Lian-Jie-Du-Decoction could regain the balance of the disturbed metabolic status common in the two cholestasis injuries, e.g., unbalanced redox system and disturbed gut flora; and perturbed urea cycle in thioacetamide-intoxicated model and energy crisis (disturbed Kreb's cycle and oxidation of branched chain amino acid) in bile duct ligation model, respectively.

show abstract

Section: Introductionmentioning

confidence: 99%

Metabolomic Assessment of Acute Cholestatic Injuries Induced by Thioacetamide and by Bile Duct Ligation, and the Protective Effects of Huang-Lian-Jie-Du-Decoction

et al. 2018

View full text Add to dashboard Cite

show abstract

“…In a metabolomics study, HLJDD decreased the levels of glutamine and γ-aminobutyric acid in plasma of MACO rats, which might be responsible for neuronprotection via the decline of excitotoxicity of glutamate. HLJDD also elevated acetylcholine level and maintained cholinergic neurons function [27]. The molecular mechanisms of HLJDD in the treatment of CNS are shown in Fig.…”

Section: Central Nervous System Diseasesmentioning

confidence: 89%

“…More and more clinical application cases have prompted people to explore the potential pharmacological effects and possible molecular mechanisms of HLJDD by modern pharmacology and molecular biotechnology. Modern pharmacological studies indicate that HLJDD exhibits therapeutic actions in various pathological aspects, such as hyperlipidemia [14], tumor [6,15,16], arthritis [17][18][19], sepsis [20][21][22], cardiac damage [23], liver injury [24,25], kidney disease [26], cerebral ischemia [27][28][29], type 2 diabetes mellitus (T2DM) [30,31], Alzheimer's disease (AD) [32][33][34], fungal infection [35] and inflammation [36]. In the meantime, with the deepening of researches and the continuous development of technology, more and more chemical compositions of HLJDD have been discovered.…”

Section: Introductionmentioning

confidence: 99%

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

Zhang

Zhu

2019

Chin Med

Self Cite

View full text Add to dashboard Cite

Huang-Lian Jie-Du decoction (HLJDD), a famous traditional Chinese prescription constituted by Rhizoma Coptidis, Radix Scutellariae, Cortex Phellodendri and Fructus Gradeniae, has notable characteristics of dissipating heat and detoxification, interfering with tumors, hepatic diseases, metabolic disorders, inflammatory or allergic processes, cerebral diseases and microbial infections. Based on the wide clinical applications, accumulating investigations about HLJDD focused on several aspects: (1) chemical analysis to explore the underlying substrates responsible for the therapeutic effects; (2) further determination of pharmacological actions and the possible mechanisms of the whole prescription and of those representative ingredients to provide scientific evidence for traditional clinical applications and to demonstrate the intriguing molecular targets for specific pathological processes; (3) pharmacokinetic feature studies of single or all components of HLJDD to reveal the chemical basis and synergistic actions contributing to the pharmacological and clinically therapeutic effects. In this review, we summarized the main achievements of phytochemical, pharmacological and pharmacokinetic profiles of HLJDD and its herbal or pharmacologically active chemicals, as well as our understanding which further reveals the significance of HLJDD clinically.

show abstract

“…Other studies have reported that HuangLian JieDu decoction (HJD) could inhibit ischemic neuron apoptosis by regulating PI3K/AKT and HIF-1a/VEGF (Zhang Q. et al, 2014). Further metabolomics (Zhu et al, 2018) and systemic pharmacology (Wang P. et al, 2019) studies have revealed that its anti-ischemic protective effect may also involve the Bcl-2 family such as Bak. Regulating vascular function and increasing cerebral blood flow supply is another effective strategy for stroke treatment.…”

Section: Prescription and Molecular Mechanisms In Regulating Mptp Opementioning

confidence: 99%

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

Sun

et al. 2020

Front. Pharmacol.

View full text Add to dashboard Cite

Mammalian mitochondrial permeability transition pore (MPTP), across the inner and outer membranes of mitochondria, is a nonspecific channel for signal transduction or material transfer between mitochondrial matrix and cytoplasm such as maintenance of Ca 2+ homeostasis, regulation of oxidative stress signals, and protein translocation evoked by some of stimuli. Continuous MPTP opening has been proved to stimulate neuronal apoptosis in ischemic stroke. Meanwhile, inhibition of MPTP overopening-induced apoptosis has shown excellent efficacy in the treatment of ischemic stroke. Among of which, the potential molecular mechanisms of drug therapy for stroke has also been gradually revealed by researchers. The characteristics of multi-components or multitargets for ethnic drugs also provide the possibility to treat stroke from the perspective of mitochondrial MPTP. The advantages mentioned above make it necessary for us to explore and clarify the new perspective of ethnic medicine in treating stroke and to determine the specific molecular mechanisms through advanced technologies as much as possible. In this review, we attempt to uncover the relationship between abnormal MPTP opening and neuronal apoptosis in ischemic stroke. We further summarized currently authorized drugs, ethnic medicine prescriptions, herbs, and identified monomer compounds for inhibition of MPTP overopening-induced ischemic neuron apoptosis. Finally, we strive to provide a new perspective and enlightenment for ethnic medicine in the prevention and treatment of stroke by inhibition of MPTP overopeninginduced neuronal apoptosis.

show abstract

Metabolomics-based mechanisms exploration of Huang-Lian Jie-Du decoction on cerebral ischemia via UPLC-Q-TOF/MS analysis on rat serum

Cited by 38 publications

References 38 publications

Metabolomic Assessment of Acute Cholestatic Injuries Induced by Thioacetamide and by Bile Duct Ligation, and the Protective Effects of Huang-Lian-Jie-Du-Decoction

Metabolomic Assessment of Acute Cholestatic Injuries Induced by Thioacetamide and by Bile Duct Ligation, and the Protective Effects of Huang-Lian-Jie-Du-Decoction

Huang-Lian Jie-Du decoction: a review on phytochemical, pharmacological and pharmacokinetic investigations

Mitochondrial MPTP: A Novel Target of Ethnomedicine for Stroke Treatment by Apoptosis Inhibition

Contact Info

Product

Resources

About